Application of 19573-83-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19573-83-2, name is 2,5-Dichloro-4,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.
EXAMPLE II-5 STR42 Process (c) 25 g (0.2 mol) of 4-amino-thiophenol are dissolved in 150 ml of N-methyl-pyrrolidone. 12.3 g (0.22 mol) of powdered potassium hydroxide and subsequently 35.4 g (0.2 mol) of 2,5-dichloro-4,6-dimethyl-pyrimidine are added to the solution. This mixture is warmed at 120 C. for 5 hours and stirred into 1 liter of water after cooling. The crystals are filtered off under suction, washed with water and dried. 46.2 g (87% of theory) of 2-(4-amino-phenyl-mercapto)-5-chloro-4,6-dimethyl-pyrimidine with melting point of 160-161 C. are obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19573-83-2, 2,5-Dichloro-4,6-dimethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Bayer Aktiengesellschaft; US4797146; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia