Category: 19646-07-2

Related Products of 19646-07-2 ,Some common heterocyclic compound, 19646-07-2, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Chloro-4,5-dimethoxy-pyrimidine To a solution of 10 g (55.9 mmol) 2,4-dich.oro-5-methoxy-pyrimidine in 200 mL MeOH was added 7.7 g (55.9 mmo.) K2CO3. The reaction mixture was stirred at room temperature for 24 h, then the volatiles were removed in vacuo. The residue was diluted with EtOAc (200 mL) and water (100 mL). The organic layer was separated, dried (Na2S04), and evaporated affording 9,0 g (92%) 2-chioro-4,5- dimethoxy-pyrimidine as a fluffy white solid which was used in subsequent steps without further purification. LCMS [M+H]+ =175.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19646-07-2, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WOLKENBERG, Scott; HARRISON, Scott, T.; BARROW, James, C.; ZHAO, Zhijian; MELAMED, Jeffrey; KETT, Nathan; ZARTMAN, Amy; WO2011/109267; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 19646-07-2

Intermediate 3: -Chloro-5-methoxypyrimidine2,4-Dichloro-5-methoxypyrimidine (43g, 0.24mol), zinc dust (86g, 1.32mol), ethanol (200 mL) and water (200 mL) were heated under reflux for 4h. The hot mixture was filtered and the ethanol was removed under reduced pressure. After cooling, the product was extracted into diethyl ether. Recrystallisation from light petroleum (b.p.: 40-60°C) gave 2-chloro-5-methoxypyrimidine (20g, 58percent).Mass: (ES+) 145 (M+H)+ NMR: 5H ( 6-DMSO) 3.92 (3H, s) and 8.55 (2H, s).

The synthetic route of 19646-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter; WO2011/144578; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 19646-07-2 , The common heterocyclic compound, 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45g, 2.5mmol) and ammonia in methanol (2N, 20ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20- 60percent ethyl acetate/ petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+ = 160

The synthetic route of 19646-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; ASTEX THERAPEUTICS LIMITED; WO2009/150240; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 19646-07-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine, molecular formula is C5H4Cl2N2O, molecular weight is 179, as common compound, the synthetic route is as follows.

2, 4-dichloro-5-methoxy-pyrimidine (100g) is dissolved in methanol, the reaction of ammonia gas at room temperature 24 hours. Reaction solution to dryness under reduced pressure, obtaining white solid, by adding petroleum ether/ethyl acetate (the 10 […] 1) beating 3-5 time, suction filtration, the white solid obtained 61 g.

Statistics shows that 19646-07-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-methoxypyrimidine.

Reference:
Patent; Shanghai Pharmaceutical Co., Ltd. Allist; Luo, Huibing; Wu, Yong; Zhou, Huayong; (67 pag.)CN105218561; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine. A new synthetic method of this compound is introduced below., Safety of 2,4-Dichloro-5-methoxypyrimidine

Production Example 1Synthesis of 2-methoxy-4-methylpyrimidin-5-ol (Prep 1-5)(1) 2-Chloro-5-methoxy-4-methylpyrimidine (Prep 1-1)2,4-Dichloro-5-methoxypyrimidine (10 g) was dissolved in THF (100 ml), and while cooling, iron(III) acetylacetone (1.97 g), methyl magnesium chloride (3.0 M: 22.4 ml) were then added to the solution. The obtained mixture was stirred at room temperature overnight. Thereafter, iron(III) acetylacetone (1.97 g), and methyl magnesium chloride (3.0 M: 22.4 ml) were added to the reaction solution further twice. Thereafter, a 1 N hydrochloric acid aqueous solution was added to the reaction mixture, and diethyl ether was then added to the reaction solution to carry out liquid separation and extraction. The organic layer was dried over magnesium sulfate, and the solvent was then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate), so as to obtain the title compound (6.6 g).1H-NMR (400 MHz, CDCl3) 5 (ppm): 2.46 (s, 3H), 3.92 (s, 3H), 8.06 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19646-07-2, 2,4-Dichloro-5-methoxypyrimidine.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; US2012/95031; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia