Category: 19808-30-1

Application of 19808-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19808-30-1, name is 5-Bromopyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below.

Step 3: 5-Bromo-4-chloropyrimidine[0362] Into a 500-mL round-bottomed flask was charged with 5- bromopyrimidin-4-ol (22 g, 63.22 mmol, 1.00 equiv, 50 %), N,N- dimethylbenzenamine (4 mL), POCI3 (266.8 g). The resulting solution was stirred at 1300C in an oil bath overnight. The mixture was cooled down to room temperature and diluted with ether (1 L). The pH was adjusted to 9 with sodium bicarbonate/water. The resulting mixture was extracted with ether (4×1 L). Combined organic layers were washed with brine (2×1 L), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum affording 5-bromo-4- chloropyrimidine as black liquid (15 g, 124%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19808-30-1, 5-Bromopyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; KALYPSYS, INC.; KAHRAMAN, Mehmet; SMITH, Nicholas, D.; BONNEFOUS, Celine; NOBLE, Stewart, A.; PAYNE, Joseph, E.; WO2010/88518; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 19808-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19808-30-1, name is 5-Bromopyrimidin-4(3H)-one, molecular formula is C4H3BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 5-bromopyrimidin-4-ol (1-111) (40 g, 0.22 mol) in POCI3 (300 mL) was added in a dropwise manner DIPEA (29 g, 0.22 mol) at room temperature. Then the resulting mixture was heated to reflux for 3 hr. TLC (petroleum ether/EtOAc 1 :1) showed the reaction was complete. Excess POCI3 was removed through distillation under reduced pressure. The residue was poured into ice-water (300 mL) slowly with stirring. The mixture was extracted with EtOAc (2 x 300 mL), the combined organic layers were washed with water (300 mL), brine (300 mL), dried over Na2S04 and concentrated under vacuum. The residue was purified by silica gel chromatography (petroleum ether/EtOAc from 20:1 to 10:1) to give 5-bromo-4-chloropyrimidine (1-112) (25 g, 60%) as a yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19808-30-1, 5-Bromopyrimidin-4(3H)-one.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 19808-30-1 , The common heterocyclic compound, 19808-30-1, name is 5-Bromopyrimidin-4(3H)-one, molecular formula is C4H3BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example 6 5-Bromopyrimidin-4(3H)-one (459 mg) was dissolved in N,N-dimethylformamide (13 mL), then with cooling with ice, sodium hydride (55%, 137 mg) was added, followed by stirring at the same temperature for 30 minutes. Then, 1-(chloromethyl)-4-methoxybenzene (392 muL) was added, followed by stirring at room temperature for 15 hours. Water was added to the reaction mixture, followed by extraction with chloroform. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 4:1 to 2:1) to obtain 5-bromo-3-(4-methoxybenzyl)pyrimidin-4(3H)-one (382 mg) as a white solid.

The synthetic route of 19808-30-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP1947086; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 19808-30-1, 5-Bromopyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19808-30-1, blongs to pyrimidines compound. Application In Synthesis of 5-Bromopyrimidin-4(3H)-one

EXAMPLE 12: 5-bromo-4-chloropyrimidine15 A stirred solution of 5-bromopyrimidin-4-ol (650mg, 3.73mmol) in POCI3 (in excess) was heated at 100C overnight. The reaction mixture was cooled and concentrated under reduced pressure. Crude product was dissolved in ethyl acetate and this mixture was slowly poured into saturated sodium bicarbonate solution. The ethyl acetate layer was separated and washed with brine solution, and dried over anhydrous sodium sulphate and concentrated to get the desired product 15 as yellow solid, 300mg (Yield- 43%). The product was confirmed by 1HNMR and MS spectrum analysis. 1H NMR (400 MHz, CDC13) delta: 8.86 (s, 1H), 8.82 (s, 1H); MS- 192 (M+l).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19808-30-1, its application will become more common.

Reference:
Patent; ARRIEN PHARMAEUTICALS LLC; VANKAYALAPATI, Hariprasad; APPALANENI, Rajendra, P.; REDDY, Y., Venkata Krishna; WO2012/135631; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 19808-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19808-30-1, name is 5-Bromopyrimidin-4(3H)-one, molecular formula is C4H3BrN2O, molecular weight is 174.9834, as common compound, the synthetic route is as follows.

Reference Example 3 5-Bromopyrimidin-4(3H)-one (578 mg) was dissolved in N,N-dimethylformamide (15 mL), and potassium carbonate (685 mg) and methyl iodide (247 muL) were added, followed by stirring at room temperature for 24 hours. Water was added to the reaction mixture, followed by extraction with chloroform. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 1:1) to obtain 5-bromo-3-methylpyrimidin-4(3H)-one (337 mg) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 19808-30-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Astellas Pharma Inc.; EP1947086; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 19808-30-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19808-30-1, name is 5-Bromopyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Step T1: 5-Bromo-4-methoxy-pyrimidine A mixture of 5-bromo-3H-pyrimidin-4-one (Step T2) (17.9 mmol) and POCI3 (179 mmol) was stirred at 80 C. for 1 h and concentrated. The residue was dissolved in CH2Cl2 (30 mL) and cooled to 5 C. MeOH (20 mL) was added and the mixture was stirred for at rt 1 h and concentrated. The residue was triturated in CH2Cl2 to afford the title compound as a white solid. ESI-MS: [M+H]+ 189/191 (MS 1).

According to the analysis of related databases, 19808-30-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; Cotesta, Simona; Furet, Pascal; Guagnano, Vito; Holzer, Philipp; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea; US2013/317024; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia