Category: 19875-04-8

Application of 19875-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19875-04-8, name is 2-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 6-[5-(5-Fluoro-2-oxo-2H-pyridin-l-ylmethyl)-pyridin-3-yl]-l-methyl-3,4-dihydro-lH- quinolin-2-one; To a solution of 6-(5 -chloromethyl-pyridin-3 -yl)- 1 -methyl-3 ,4-dihydro- 1 H-quinolin-2-one (intermediate A-3 [B]) (0.05 g, 0.147 mmol) in DMF (1 mL) was added 5-fluoro-lH-pyridin-2- one (0.019 g, 0.174 mmol) and K2C03 (0.048 g, 0.349 mmol) and the reaction mixture was stirred at room temperature over night. The mixture was evaporated to dryness and the residue purified by silica gel flash chromatography eluting with a 0 to 5% MeOH-DCM gradient to give 6-[5 -(5 -fluoro-pyridin-2-yloxymethyl)-pyridin-3 -yl] – 1 -methyl-3 ,4-dihydro- 1 H-quinolin-2-one (0.016 g, 25 %), as colorless solid,

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19875-04-8, 2-Methylpyrimidin-4(3H)-one.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KUHN, Bernd; MAERKI, Hans, P.; MAYWEG, Alexander, V.; TAN, Xuefei; WO2014/139981; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 19875-04-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19875-04-8, name is 2-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, molecular weight is 110.11, as common compound, the synthetic route is as follows.

(b) 11 g of 2-methyl-4-pyrimidone were introduced into 50 ml of phosphorus oxychloride, and the mixture was heated at 80 C. until a clear solution was produced. Excess phosphorus oxychloride was removed by distillation in vacuo, and the residue was poured into ice-water. While cooling, the solution was neutralized with potassium hydroxide solution and extracted with dichloromethane. The organic extracts were dried (Na2 SO4) and concentrated in vacuo, and column chromatography resulted in 8 g of 4-chloro-2-methylpyrimidine (melting point 50-60 C.).

Statistics shows that 19875-04-8 is playing an increasingly important role. we look forward to future research findings about 2-Methylpyrimidin-4(3H)-one.

Reference:
Patent; Hoechst Aktiengesellschaft; US4956366; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia