Sep-21 News New downstream synthetic route of 24034-73-9

According to the analysis of related databases, 20090-69-1, the application of this compound in the production field has become more and more popular.

Application of 20090-69-1, Adding some certain compound to certain chemical reactions, such as: 20090-69-1, name is 2-Chloro-4-methylpyrimidin-5-amine,molecular formula is C5H6ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20090-69-1.

To a stirred solution of 2-chloro-4-methylpyrimidin-5-amine (2 g, 14.706 mmol, CAS RN20090-69-1) in DCM (50 mL) was added acetic anhydride (2.96 mL, 29.412 mmol) followed by triethyl amine (6.15 mL, 44.118 mmol) and reaction mixture was stirred at 25C for 16 h. After completion of the reaction, the mixture was evaporated.. The crude product was purified by chromatography over silica gel (23-26% EtOAc/n-hexane) to afford the compound as an offwhite solid (2.49 g, 91%). MS (ESI): mlz = 186.1 [M+H]+

According to the analysis of related databases, 20090-69-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BUETTELMANN, Bernd; KOCER, Buelent; KUHN, Bernd; PRUNOTTO, Marco; RICHTER, Hans; RITTER, Martin; (217 pag.)WO2017/137334; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extended knowledge of 20090-69-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20090-69-1, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 20090-69-1, 2-Chloro-4-methylpyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20090-69-1, blongs to pyrimidines compound. Product Details of 20090-69-1

The raw material 15 (83 mg, 1 eq) was dissolved in 2 ml of chloroform, 45.4 mg (1.2 eq) of potassium acetate and acetic anhydride (157.5 mg, 4 eq) were added and stirred at room temperature for 1 h. TLC was monitored and the reaction was complete. (6eq) was added to the room temperature and cooled to room temperature. After the reaction overnight, the intermediate reaction was monitored completely. The solvent was dried to obtain yellow solid 16 (100 mg) in 73.7% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20090-69-1, its application will become more common.

Reference:
Patent; SICHUAN BAILI PHARMACEUTICAL CO LTD; WU, YONG; ZHU, YI; HAI, LI; WANG, YIXI; LI, JIE; (23 pag.)CN105906621; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 20090-69-1

Statistics shows that 20090-69-1 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidin-5-amine.

Synthetic Route of 20090-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20090-69-1, name is 2-Chloro-4-methylpyrimidin-5-amine, molecular formula is C5H6ClN3, molecular weight is 143.57, as common compound, the synthetic route is as follows.

To a solution of 2-chloro-4-methylpyrimidin-5-amine (300 mg 2.090 mmol) in THF (20 mL) was added triphosgene (620 mg 2.090 mmol) in one portion. The mixture was stirred at 60 for 20 min. LCMS analysis showed the starting material had disappeared ES-LCMS m/z 202.1 (M+MeOH)

Statistics shows that 20090-69-1 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidin-5-amine.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia