Category: 2022-78-8

Application of 2022-78-8 ,Some common heterocyclic compound, 2022-78-8, molecular formula is C4H3FN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 4 1-(2-Hydroxyethyl)-5-fluoropyrimid-2-one 5-Fluoropyrimid-2-one (0.008 mol) was dissolved in a solution of potassium hydroxide (0.008 mol) in absolute ethanol (100 ml) at 80 C. and ethylene bromohydrin (0.008 mol) added gradually with stirring. The alkylation was incomplete when the pH had become neutral. The reaction was further monitored by chromatography and equivalent amounts of potassium hydroxide and ethylene bromohydrin added until all the pyrimidine had been alkylated. The reaction mixture was then filtered and the filtrate evaporated to dryness before the residue was triturated with ether and extracted with warm acetone. Evaporation of the acetone solution left the title compound in 50% yield, m.p. 134-136 C. after recrystallisation from ethanol; Found: C, 45.83; H, 4.42; Calc. for C6 H7 FN2 O2: C, 45.58; H, 4.46.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2022-78-8, its application will become more common.

Reference:
Patent; Nyegaard & Co. A/S; US4395406; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2022-78-8, name is 5-Fluoropyrimidin-2(1H)-one, the common compound, a new synthetic route is introduced below. COA of Formula: C4H3FN2O

EXAMPLE 24 1-(3-Methylphenylthio)methyl-5-fluoropyrimidin-2-one 3-(Chloromethylthio)toluene (6.5 mmol) was added to a solution of 5-fluoropyrimidin-2-one (6.5 mmol) and triethylamine (6.5 mmol) in dichloromethane (75 ml) and the resultant mixture heated under reflux for 2 days. The solvent was then distilled off, the residue triturated with water and the residual material extracted with CCl4. Evaporation of the extracts and crystallisation of the residue from ethyl acetate gave the pure product; 0.40 g (25%), m.p. 124 C. (Found: C57.42; H4.63. Calc. for C12 H11 FN2 OS: C57.59; H4.43) 1 H NMR (DMSO d6); delta 2.28 (Me), 5.17(CH2), 7.2 (Ph), 8.05 (H-4), 8.70 (H-6). IR (KBr): 1670 cm-1 (CO), MS [70 eV, m/z (% rel. int.)]: 250 (8,M), 137(11), 136)36), 135(10), 128(7), 127(100), 100(34), 91(9).

The synthetic route of 2022-78-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nyegaard & Co. A.S.; US4596870; (1986); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia