Category: 205672-25-9

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine, molecular formula is C4H3BrClN3, molecular weight is 208.44, as common compound, the synthetic route is as follows.Computed Properties of C4H3BrClN3

Synthesis of 2-Chloro-5- (2-ethoxyvinyl)-pyrimidin-4-ylamine (2):; A 500 mL round bottomed flask is charged with 5-bromo-2-chloropyrimidin-4-ylamine (1) (lOg, 48 mmol), tetrakis (triphenylphosphine) palladium (0) (2.8g, 2.5 mmol), and toluene (200 mL). Tributyl- (2-ethoxyvinyl)-stannane (22g, 60 mmol) is added and the reaction heated to 110C with stirring for approximately 15 hours. After cooling to room temperature, the solution is diluted with 100 mL ethyl acetate and washed with water and brine. The organic extract is dried over Na2S04, filtered, and concentrated under reduced pressure. Purification by column chromatography (Si02, Hexane: Ethyl acetate/5: 1) provides 2 (4.4 g, 46%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,205672-25-9, 4-Amino-5-bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; IRM LLC; WO2005/80393; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine, molecular formula is C4H3BrClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4-Amino-5-bromo-2-chloropyrimidine

A 100 mL round bottom flask was charged with 5-bromo-2-chloropyrimidin-4- amine (8.0 g, 40 mmol), N,N-diisopropylethylamine (16.0 g, 120 mmol) and tert- butyl piperazine-l-carboxylate (11.0 g, 60 mmol). The resulting mixture was heated at reflux overnight. Work-up: the solvent was evaporated. The residue was re- crystallized from ethanol to afford 9.0 g (65%) of the product as a white solid. MS m/z: 358 (M+H+).

With the rapid development of chemical substances, we look forward to future research findings about 205672-25-9.

Reference:
Patent; KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; NOBLE, Stewart, A.; WO2011/112766; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3BrClN3

A solution of 5-bromo-2-chioropyrimidin-4-amine (650 mg, 3.12 mmol), tert-butyl (4-methylpiperidin-4-yl)carbamate (835 mg, 3.90 mmol), and 4-methylmorpholine(411 tL, 3.74 mmol) in NMP (6.25 mL) was stirred in amicrowave reactor for 90 mm at 130 C. The resultingresidue was poured into water (100 mL) and was stirred atRT for 5 mm. The solid formed was filtered oil and driedunder high vacuum for 16 h to give tert-butyl (1 -(4-amino-5-bromopyrimidin-2-yl)-4-methylpiperidin-4-yl)carbamate(880 mg, 2.28 mmol). MS mlz 387.3 (M+H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 205672-25-9, 4-Amino-5-bromo-2-chloropyrimidine.

Reference:
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 205672-25-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.

1 L reaction flask was charged with 20.8 g (0.1 mol) of Compound I and 208 mL of tetrahydrofuran,After stirring and dissolving,The system was cooled to -78 C. After the temperature was stabilized, 62.5 mL of n-butyllithium-n-hexane (15% concentration) was added dropwise. A solution of 12.9 g (0.125 mol) of N-methoxy-N-methylacetamide and 129 mL of tetrahydrofuran was added dropwise while maintaining the temperature for 10 min. After stirring for 1 h, the system was warmed to 0 C and 100 mL of saturated ammonium chloride solution was added. After stirring for 30 min, the mixture was extracted with 3X 300 mL of ethyl acetate. The organic layers were combined and the organic layer was washed with 3X 300 mL of saturated brine and dried over anhydrous magnesium sulfate Dried, filtered and concentrated to give 15.8 g of crude yellow solid, yield: 91.9%, used directly in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,205672-25-9, 4-Amino-5-bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Han Xiaojun; Huang Shuang; Qian Gang; Liu Liping; Sheng Zecui; (9 pag.)CN105153149; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 205672-25-9 ,Some common heterocyclic compound, 205672-25-9, molecular formula is C4H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 500 mL round bottomed flask is charged with 5-bromo-2-chloropyrimidin-4-ylamine (1) (lOg, 48 mmol), tetrakis(triphenylphosphine)palladium(0) (2.8g, 2.5 mmol), and toluene (200 mL). Tributyl- (2-ethoxyvinyl)-stannane (22g, 60 mmol) is added and the reaction heated to 110C with stirring for approximately 15 hours. After cooling to room temperature, the solution is diluted with 100 mL ethyl acetate and washed with water and brine. The organic extract is dried over Na2S04, filtered, and concentrated under reduced pressure. Purification by column chromatography (Si02, Hexane : Ethyl acetate/ 5 :1) provides 2 (4.4 g, 46%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,205672-25-9, its application will become more common.

Reference:
Patent; IRM LLC; WO2005/107760; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia