Category: 20781-06-0

Reference of 20781-06-0, Adding some certain compound to certain chemical reactions, such as: 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde,molecular formula is C5H6N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20781-06-0.

A. Preparation of 2,6-dipivaloylamino-5-carboxaldehydepyrimidine STR40 To a 250 mL round bottom flask flame dried under a nitrogen atmosphere was suspended 2.0 g (14.5 mmol) of 2,6-diamino-5-carboxaldehydepyrimidine [as described in J. Med. Chem., 26:667-673 (1983)] in 16 mL of anhydrous DMF, followed by the addition of 16 mL (78.9 mmol) of trimethylacetic anhydride. This mixture was then heated to 160 C. for 1 hours. The dark brown solution was cooled to ambient temperature and the volatiles were removed in vacuo. The crude residue was dissolved in 100 mL of MeCl2 and washed 3 times with 100 mL hot water, dried over Na2 SO4, and removed in vacuo. The solid was then flash chromatographed on silica gel eluding with 1:1 EtOAc/MeCl2. The correct fractions were combined and removed in vacuo to give 2.4 g (54%) of 2,6-dipivaloylamino-5-carboxaldehydepyrimidine as a white solid. Rf =0.21 (1:1 EtOAc/MeCl2) mp.=182-184 C. Mass (FAB) M+1 HRMS=Calcd.: 307.1770; Found: 307.1758 IR (KBr, cm-1)=802, 836, 1001, 1130, 1208, 1256, 1327, 1370, 1397, 1452, 1485, 1625, 1663, 1718, 2969, 3223, 3511 UV (EtOH) lambdamax =291, 248 (epsilon=14,856, 28,220) 1 H NMR (300 MHz, CDCl3) delta1.35 (S, 9H), 1.38 (S, 9H), 8.61 (br s, 1H), 8.87 (s, 1H), 9.85 (s, 1H), 11.42 (br s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eli Lilly and Company; US5426110; (1995); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20781-06-0, blongs to pyrimidines compound. HPLC of Formula: C5H6N4O

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20781-06-0, its application will become more common.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2,4-Diaminopyrimidine-5-carboxaldehyde

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6N4O, blongs to pyrimidines compound. Formula: C5H6N4O

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 2,4-Diaminopyrimidine-5-carboxaldehyde

EXAMPLE 10 2,7-Diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine (Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde, and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture was heated at reflux for 4 hours, allowed to cool to room temperature, and the precipitated product was filtered and washed with diethyl ether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine, mp 325-332 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde.

Reference:
Patent; Warner-Lambert Company; US5620981; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 20781-06-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

1mmol 2,4-diamino-5-pyrimidinecarbaldehyde with1.1mmol benzoyl hydrazide is dissolved in 25ml ethanol solvent,Add 0.15 mmol of trifluoroacetic acid,Heat and stir the reaction for 6-8h,TLC monitors the progress of the reaction,Add 50ml of water after the reaction is completed.Stirring solids precipitated,Filtering,Drying gave a yellow solid.Yield 79%, m.p. 250-252 C;

According to the analysis of related databases, 20781-06-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Central China Normal University; He Hongwu; Zhou Yuan; (70 pag.)CN109503496; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Diaminopyrimidine-5-carboxaldehyde, blongs to pyrimidines compound. Recommanded Product: 2,4-Diaminopyrimidine-5-carboxaldehyde

EXAMPLE 60 6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine To a solution of 0.23 g 60% sodium hydride suspension in 11.0 mL of 2-ethoxyethanol was added 4.18 g of 2,6-dibromophenylacetonitrile and 2.00 g of 2,4-diaminopyrimidine-5-carboxaldehyde. The reaction was refluxed for 4 hours, cooled, and poured into ice water. The residue was washed well with acetonitrile then diethyl ether to give 3.62 g of 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine, CIMS (1% NH3 in CH4): 422=M+ +C2 H5, 396 (Base), 394=M+ +H, 393=M+; mp 284-289 C.

The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Blankley; Clifton John; Doherty; Annette Marian; Hamby; James Marino; Panek; Robert Lee; Schroeder; Mel Conrad; Showalter; Howard Daniel Hollis; Connolly; Cleo; US5733913; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 20781-06-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde, molecular formula is C5H6N4O, molecular weight is 138.1273, as common compound, the synthetic route is as follows.

General procedure: A mixture of 2-(benzo[d] thiazol-20-yl)acetonitrile 4 (1.0 mmol,0.17 g) and pyrimidine aldehyde 2 or 8 (1.0 mmol) was stirred at 25 C for 10-15 min in ethanol (10 ml) which contained piperidine (2.0 mmol, 0.2 ml). The reaction was monitored by TLC. The formed solid was filtrated and washed with hexane (2 x 10 ml) to give thecorresponding compounds 5 and 9a-d. 4.4.2.1 (E)-2-(Benzo[d]thiazol-2′-yl)-3-(2″,4″-diaminopyrimidin-5″-yl)acrylonitrile (5) Yellow powder; yield 77%; mp 280 C; IR (KBr, cm-1): 3395, 3307 (br, NH2), 2101 (CN), 2733 (C-H aliphatic), 1565 (C=C); 1H-NMR [DMSO-d6, 400 MHz]: (delta, ppm) 6.86-6.88 (bs, 2H, NH2, exchangeable with D2O), 7.47 (t, 1H, H5-benzothiazole, J = 8.0 Hz), 7.55 (t, 1H, H6-benzothiazole, J = 8.0 Hz), 8.05 (d, 1H, H4-benzothiazole, J = 8.0 Hz), 8.11 (d, 1H, H7-benzothiazole, J = 8.0 Hz), 8.30 (brs, 2H, NH2, exchangeable with D2O), 8.52 (s, 1H, H6-pyrimidine), 8.87 (olefinic H); 13C-NMR [DMSO-d6, 100 MHz]: (delta, ppm) 106.4 (C5-pyrimidine), 110.1 (C2′), 112.2 (CN), 122.3 (C7-benzothiazole), 133.3 (C4-benzothiazole), 139.9 (C5-benzothiazole), 139.9 (C6-benzothiazole), 153.1 (C3’a-benzothiazole), 160.0 (C6-pyrimidine), 161.5 (C3’b-benzothiazole), 162.9 (olefinic C), 164.5 (C4-pyrimidine), 164.8 (C2-benzothiazole), 167.1 (C2-pyrimidine); Anal. Calcd for C14H10N6S: C, 57.13; H, 3.42; N, 28.55; S, 10.89; Found: C, 57.18; H, 3.33; N, 28.63; S, 10.96; Anal. Calcd for C14H10N6S·2HBr: C, 36.86; H, 2.65; N, 18.42; S, 7.03; Found: C, 37.05; H, 2.45; N, 18.44; S, 7.05.

The chemical industry reduces the impact on the environment during synthesis 20781-06-0, I believe this compound will play a more active role in future production and life.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde, molecular formula is C5H6N4O, molecular weight is 138.1273, as common compound, the synthetic route is as follows.category: pyrimidines

EXAMPLE 1 2,7-Diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine (Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture is heated at reflux for 4 hours, cooled, and the insoluble product washed with diethylether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine, mp 325-332 C. (MS).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Blankley; Clifton John; Doherty; Annette Marian; Hamby; James Marino; Panek; Robert Lee; Schroeder; Mel Conrad; Showalter; Howard Daniel Hollis; Connolly; Cleo; US5733913; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 20781-06-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde. A new synthetic method of this compound is introduced below.

A mixture of 0.188 g (1 mmol) of compound of formula V and 0.447 g (1.5 mmol) of compound of formula III-1, 0.126 g (2 mmol) of sodium cyanoborohydride was added and maintained in a reflux state for 24 hours in 15 mL of methanol, The water was washed with ethyl acetate and the organic phase was washed with saturated brine and the organic phase was concentrated (the solvent was removed under reduced pressure). The residue was purified by silica gel column chromatography (Eluent: methanol: dichloromethane = 1: 10, v / v) to give a white solid (IB-1) The yield was 78%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; East China University of Science and Technology; Zhu Jin; Huang Jin; Chen Wenhua; Yao Xue; Ling Dazheng; Wang Manjiong; Jiang Hualiang; Li Jian; (21 pag.)CN106938997; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia