Category: 213265-83-9

213265-83-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Ethyl 5-aminobenzo [b] selenophene-2-carboxylate (1 eq), 4,6-dichloro-5-fluoropyrimidine (3eq)Was dissolved in ethanolUsing a microwave reactor, stir three times for 30 min at 80 C.After completion of the reaction,Solvent was removed from the rotary evaporator and colum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 213265-83-9, 4,6-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY; SAMSUNG LIFE PUBLIC WELFARE FOUNDATION; LIM, DONG-YEOL; CHOI, HONG-LIM; Metrea, Amul; Heo, Su-Yang; Kim, Sun-Young; Nam, Do-Hyun; (55 pag.)KR2017/41562; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, A common compound: 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Intermediate A39-2 (200mg, 1.07mmol) was dissolved in tetrahydrofuran (5mL), was added 4,6-dichloro-5-fluoropyrimidine (179mg, 1.07mmol),Diisopropylethyl amine (414mg, 3.21mmol), 50 stirred overnight, cooled to room temperature, spin dry solvent, the residue was purified by column chromatography (dichloromethane:Methanol = 150: 1) to give a colorless oil (240mg, 71%). 1HNMR (400MHz, CDCl3) delta8.23 (s, 1H), 7.51 (s, 1H),7.45-7.40 (m, 4H), 6.30 (s, 1H), 5.55 (s, 1H), 4.79 (d, J = 6.0Hz, 2H), 3.89 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213265-83-9.

Reference:
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, Adding some certain compound to certain chemical reactions, such as: 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213265-83-9.

Intermediate A35-5 (200mg, 0.92mmol) was dissolved in tetrahydrofuran (10mL), was added 4,6-dichloro-5-fluoropyrimidine (154mg, 0.92mmol),Diisopropylethyl amine (357mg, 2.77mmol), 50 stirred overnight, cooled to room temperature, spin dry solvent, the residue was purified by column chromatography (dichloromethane:Methanol = 50: 1) to give an off-white solid (200mg, 62%). 1HNMR (400MHz, CDCl3) delta8.61 (d, J = 4.8Hz, 1H), 8.56 (s,1H), 8.24 (s, 1H), 7.76 (s, 1H), 7.69 (s, 1H), 7.55 (d, J = 11.6Hz, 1H), 5.78 (s, 1H), 4.84 (d, J = 6.0 hz,2H), 2.65 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213265-83-9.

Reference:
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The common heterocyclic compound, 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 213265-83-9

0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer = about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0. 1 g of 4-CHLORO-6- (CIS-3, 5-dimethyl piperidino) -5-fluoropyrimidine and 0.05 g of 4-chloro- 6- (TRANS-3, 5-dimethylpiperidino) pyrimidin. cis diastereomer: H-NMR : 0.84 (dd, 1H), 0.93 (d, 6H), 1.64-1. 78 (m, 2H), 1.84-1. 92 (m, 1H), 2.46 (dd, 2H), 4.48 (d, 2H), 8. 11 (s, 1H) trans diastereomer: H-NMR : 0.96 (d, 6H), 1.51 (t, 2H), 1.96-2. 06 (m, 2H), 3.40 (dd, 2H), 3.83 (dd, 2H), 8. 10 (s, 1H)

The synthetic route of 213265-83-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, the common compound, a new synthetic route is introduced below.

To a stirred solution of 20.2 (120 mg, 0.000722 mol) in n-butanol (0.5 mL) was added NH4OH (1 mL). The reaction mixture was heated at 90 C. for 2.5 hr in a sealed tube. The reaction mixture was cooled to 0 C., and the resulting solid was filtered and dried under vacuum to give 20.3 (60 mg, 57%). 1H-NMR (DMSO-d6 500 MHz): delta 8.03 (s, 1H), 7.60 (s, 2H); m/z: 148 [M+1]+.

Statistics shows that 213265-83-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-5-fluoropyrimidine.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia