Category: 2134-38-5

Application of 2134-38-5, Adding some certain compound to certain chemical reactions, such as: 2134-38-5, name is Ethyl 2-methylpyrimidine-5-carboxylate,molecular formula is C8H10N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2134-38-5.

Step 2: Preparation of N-(4-chloro-6-(ethylamino)pyrimidin-5-yl)-2-methylpyrimidine-5- carboxamide.To a mixture of 6-chloro-N4-ethylpyrimidine-4,5 -diamine (16 g, 91 mmol) and ethyl -2- methylpyrimidine-5-carboxylate (15 g, 90 mmol) in 50 ml of dimethyl ether at RT, a slurry of sodium teri-butoxide (9.1 g, 92 mmol) in DME (25 ml) was added over the course of 1 min (reaction internal temperature rose to 43 C) . The reaction mixture was then stirred at RT for 2 h, after which it was quenched by the addition of water (75 ml) and EtOAc (75 ml). The reaction mixture was extracted with EtOAc (75 ml x 2). The aqueous layer was then charged with acetic acid (5.3 ml, 92 mmol) and a slurry formed. The solid was collected by filtration, then washed with 75 ml of 1 : 1 DME : water, after which it was dried under vacuum at 35 C for 16 h to provide N-(4-chloro-6-(ethylamino)pyrimidin-5-yl)-2- methylpyrimidine-5-carboxamide. MS (ESI) Calc’d for Ci2Hi4ClN60 [M+H]+: 293, found: 293.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2134-38-5, Ethyl 2-methylpyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth Ann; FONG, Kin Chiu; ANTHONY, Neville John; ZHOU, Hua; KATZ, Jason D.; YANG, Lihu; LI, Chaomin; TIAN, Yuan; MU, Changwei (Charles); YE, Baijun; SHI, Feng; ZHAO, Xiaoli; FU, Jianmin; WO2015/188369; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2134-38-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2134-38-5, name is Ethyl 2-methylpyrimidine-5-carboxylate, molecular formula is C8H10N2O2, molecular weight is 166.18, as common compound, the synthetic route is as follows.

To a mixture of 6-chloro-N4-ethylpyrimidine-4,5-diamine (16 g, 91 mmol) and ethyl-2- methylpyrimidine-5-carboxylate (15 g, 90 mmol) in 50 mL of dimethyl ether at RT, a slurry of sodium iert-butoxide (9.1 g, 92 mmol) in dimethyl ether (25 mL) was added over the course of 1 min (reaction internal temperature rose to 43C) . The reaction mixture was then stirred at RT for 2 h, after which it was quenched by the addition of water (75 mL) and EtOAc (75 mL). The reaction mixture was extracted with EtOAc (75 mL x 2). The aqueous layer was then charged with acetic acid (5.3 ml, 92 mmol) and a slurry formed. The solid was collected by filtration, then washed with 75 mL of 1 : 1 DME : water, after which it was dried under vacuum at 35 C for 16 h to provide N-(4-chloro-6-(ethylamino)pyrimidin-5-yl)-2-methylpyrimidine-5-carboxamide. MS (ESI) calc’d for Ci2Hi4ClN60 [M+H]+: 293, found: 293.

Statistics shows that 2134-38-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-methylpyrimidine-5-carboxylate.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; YANG, Liping; MU, Changwei; WANG, Xiaona; SHI, Feng; YE, Baijun; ZHANG, Sixing; ZHAO, Xiaoli; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75393; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia