Category: 213745-17-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 213745-17-6, name is 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

1 C. 4-Chloro-7-cvclopentyl-7H-pyrrolof2, 3-dl vrimidine-5-carboxvlic acid; Starting material (1B, 10 g, 29 mmole) was taken in 500 mL DMF and 100 mL H20 together with palladium acetate (0.32 g, 1.4 mmole). The reaction mixture was stirred in a pressure reactor at 50 C under 100 psi carbon monoxide for 6.5 h and room temperature for 16 h. The reaction mixture was then concentrated and residue triturated with 100 mL of 1: 1 EtOAc/Ch2CI2 followed by 50 mL CH2CI2. The solid was collected after filtration and dried over P205 to furnish 21 g of an off-white solid. This solid was then triturated with a mixture of formic acid/H20 (21 mU5 mL). The solid collected after filtration and drying over P205 furnished 6.5 g of 1 C (m/z 265.1, retention time 2.5 min. with HPLC method 1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/47289; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 213745-17-6, blongs to pyrimidines compound. SDS of cas: 213745-17-6

To a pressure tube with dioxane (5 mL) was added 4-Chloro-7-cyclopentyl-5-iodo-7H- pyrrolo [2, 3-D] PYRIMIDINE, then ammonia hydroxide (5 mL). The pressure tube was sealed and heated at 120C overnight. All solvents were removed via reduced pressure, and the residue were purified through flash COLUMN (METHYLENE CHLORIDE/METHANOL : 97/3). The product was obtained as a white solid (300 mg, 92%). MS: 329.1 (MH+); HPLC Rf: 5.018 min.; HPLC purity: 99%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/56830; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia