Category: 220041-42-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 220041-42-9, name is tert-Butyl 2-chloropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of tert-Butyl 2-chloropyrimidine-4-carboxylate

Step 2: Synthesis of ( R )-tert-butyl 2-(2-methyl-4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)pyrimidine-4-carboxylate [596] Tert-butyl 2-chloropyrimidine-4-carboxylate (70 mg, 0.326 mmol) and (R)-3-methyl-1-(4-(methylsulfonyl)phenyl)piperazine (166 mg, 0.652 mmol) were dissolved in acetonitrile (2 ml), followed by addition of N,N-diisopropylethylamine (0.11 ml, 0.652 mmol), and then the resulting liquid was stirred at 100oC under nitrogen stream for 24 hours. The resulting reaction liquid was concentrated under reduced pressure, and then the residue thus obtained was subjected to MPLC (50% EtOAc/Hexanes), to obtain 120 mg of pale yellow solid (85%).

With the rapid development of chemical substances, we look forward to future research findings about 220041-42-9.

Reference:
Patent; SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho; WO2011/139107; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 220041-42-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 220041-42-9, name is tert-Butyl 2-chloropyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below.

In a 20 mE vial under nitrogen, tert-butyl 2-chloropyrimi- dine-4-carboxylate (0.200 g, 0.932 mmol), 4-methylpiperi- din-3-ol hydrochloride (0.185 g, 1.220 mmol) and triethylamine (0.52 mE, 3.73 mmol) were added to THF (14 mE) and the resulting mixture was stirred at 80 C. for 16 h. The cooled mixture was concentrated in vacuo and the residuewas purified on the ISCO using a 25 g Innoflash column (Hexane/EtOAc) to give tert-butyl 2-(3-hydroxy-4-methyl-piperidin-1-yl)pyrimidine-4-carboxylate (0.269 g, 98%) as ayellow oil which was a mixture of diastereomers. EC (Analytical MethodA): 2.081 mi ECMS (APCI): calcd forC,5H24N303 [M+H] mlz 294.18; found 294.2. ?H NMR (400 MHz, CDC13) 0 8.45 (d, J=4.7 Hz, 1H), 7.02 (d, J=4.7Hz, 1H), 4.87 (ddd, J=1.6, 4.5, 12.7 Hz, 1H), 4.74-4.63 (m, 1H), 3.30 (tt, J=4.8, 9.4 Hz, 1H), 2.98 (ddd, J=2.7, 12.1, 13.3Hz, 1H), 2.84 (dd, J=10.0, 12.7 Hz, 1H), 1.87-1.74 (m, 1H),1.70 (d, J=4.7 Hz, 1H), 1.66-1.57 (m, 1H), 1.61 (s, 9H),1.36-1.20 (m, 1H), 1.10 (d, J=6.7 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,220041-42-9, its application will become more common.

Reference:
Patent; UNIVERSITE DE MONTREAL; Martel, Alain; Tremblay, Francois; (65 pag.)US9598419; (2017); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia