Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22246-17-9, name is 7-Methoxy-3,4-dihydroquinolin-2(1H)-one, A new synthetic method of this compound is introduced below., SDS of cas: 22246-17-9
To a stirred solution of 19 (1.0 g, 5.64 mmol) in DMF (10 mL) at 0 C was added NaH (0.25 g, 6.2 mmol) and the resulting solution was stirred for 30 min. Ethyl bromoacetate (0.67 mL, 6.2 mmol) was added to the reaction mixture, while stirring at 0 C and warmed to rt. After 17 h, the reaction mixture was diluted with ethyl acetate and washed with 1.0 N HCl, saturated aqueous NaHCO3, then brine. The organic layer was dried over MgSO4, concentrated in vacuo and the residue was purified by MPLC to give 20 (1.17 g, 79%) as a white solid. 1H NMR (300 MHz, CDCl3) delta 7.08 (d, J = 8.2 Hz, 1H), 6.55 (dd, J = 8.2, 2.3 Hz, 1H), 6.33 (d, J = 2.3 Hz, 1H), 4.63 (s, 2H), 4.22 (q, J = 7.1 Hz, 2H), 3.78 (s, 3H), 2.93 – 2.85 (m, 2H), 2.76 – 2.60 (m, 2H), 1.27 (t, J = 7.1 Hz, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.