Category: 2227-98-7

Synthetic Route of 2227-98-7, Adding some certain compound to certain chemical reactions, such as: 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine,molecular formula is C6H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2227-98-7.

Compound (XII) (457 mg, 3.10 mmol) is stirred in water/ethanol (4:1, 22.5 ml) and treated with9-deazaadenine (378 mg, 2.82 mmol) and formaldehyde solution (0.21 ml, 38 %). The mixtureis stirred at ambient temperature for 3 days. A solution of sulfuric acid (2.8 ml, 1M) is added.Ethanol (5 ml) is added. The mixture is cooled to 0 C and stirred for 15 minutes. The resultingslurry is filtered and the crystals dried to give 548mg tan solid. A portion of this solid (300 mg) isstirred in water (approximately 10 ml) with Amberlite FPA91-OH resin (approximately 2 g) for 30minutes. The resin is filtered and the solution evaporated to give 143 mg white solid ((3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimid in-7-yl)methyl)-4-(methylthiomethyl)pyrrolid in-3-ol which isused in the next steps).(3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methylthiomethyl)pyrrolidin-3-ol (50 mg, 0.17 mmol) is dissolved in water (1 .0 ml) and treated with sulfuric acid (0.17 ml, 1 M, 1.0 eq). IPA (0.4 ml) is added and the resulting solution stored at 4 C resulting in formation of an oil phase. The mixture is warmed to give a solution, treated with ethanol (approximately 0.2 ml) and stored at 4 C overnight resulting in precipitation of solids from solution. The solid is filtered on filter paper and dried under vacuum.

According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALLAGHAN INNOVATION RESEARCH LIMITED; EVANS, Gary Brian; KELLY, Peter Michael; TYLER, Peter Charles; WO2014/73989; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2227-98-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

[0065] (4S)-4-{[l-(Triphenylmethyl)-lH-imidazol-4-yl]methyl}-l,3-oxazolidin-2-one or (4S)-4-{[l-(triphenylmethyl)-lH-imidazol-5-yl]methyl}-l,3-oxazolidin-2-one (P.l). A modified literature procedure [Madrigal, et al.14] was followed. (5)-Histidinol dihydrochloride (0.500 g, 2.34 mmol) and diethyl carbonate (2.86 mL, 23.61 mmol) were stirred together in ethanol (24 mL), then sodium methoxide in methanol solution (25%, 1.6 mL, 7.0 mmol) added. The mixture was heated under reflux for 72 h then the solvent was evaporated and the residue chromatographed on silica gel (CHCl3-MeOH-28% aq. NH4OH, 9: 1:0.1) to give (45)-4-(lH-imidazol-4-ylmethyl)-l,3-oxazolidin-2-one as a colourless solid (0.26 g, 1.56 mmol, 90 – 95% pure). XH NMR (500 MHz, CD3OD): delta 7.61 (d, J = 1.0 Hz, 1H), 6.93 (s, 1H), 4.45-4.40 (m, 1H), 4.18-4.12 (m, 2H), 2.86 (dd, J= 14.7, 4.8 Hz, 1H), 2.80 (dd, J= 14.8, 6.1 Hz, 1H). It was dissolved in DMF (4 mL) then triethylamine (0.42 mL, 3.00 mmol) and trityl chloride (0.489 g, 1.70 mmol) were added. The mixture was stirred for 60 h at rt then diluted with Et20 (60 mL) and the mixture washed with H20 (4 x 5mL), brine (5 mL), dried and the solvent evaporated. The residue was chromatographed on silica gel (gradient of 0 – 5% MeOH in EtOAc) to give P.l as a colourless foam (0.520 g, 54%). XH NMR (500 MHz, CD3OD): delta 7.41 (d, J = 1.4 Hz, 1H), 7.39-7.34 (m, 9H), 7.16-7.1 1 (m, 6H), 6.82 (m, 1H), 4.39 (t, J = 8.4 Hz, 1H), 4.19-4.11 (m, 2H), 2.78 (dd, J = 14.6, 4.9 Hz, 1H), 2.73 (dd, J = 14.6, 6.1 Hz, 1H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 162.1 (C), 143.6 (C x 3), 139.8 (CH), 136.6 (C), 130.9 (CH), 129.32 (CH), 129.27 (CH), 121.6 (CH), 76.9 (C), 70.4 (CH2), 53.4 (CH), 33.9 (CH2). ESI-HRMS calcd for C26H23N3Na02+, (M+Na)+, 432.1683, found 432.1677. [0066] (2S)-2-Amino-3-[l-(triphenylmethyl)-lH-imidazol-4-yl]propan-l-ol or (2S)-2- amino-3-[l-(triphenylmethyl)-lH-imidazol-5-yl]propan-l-ol (P.2). Compound P.l (0.510 g, (0109) I .25 mmol) was dissolved in 2-propanol (7 mL) and potassium hydroxide (2 M, 3 mL, 6 mmol) added. The mixture was heated at 80 C for 6 h then silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (CHCl3-MeOH-28% aq. NH4OH, 9: 1 :0.1) to give P.2 as a colourless gum (0.478 g, 100%). XH NMR (500 MHz, CD3OD): delta 7.40 (d, J = 1.4 Hz, 1H), 7.38-7.34 (m, 9H), 7.18-7.13 (m, 6H), 6.75 (m, 1H), 3.52 (dd, J= 10.9, 4.5 Hz, 1H), 3.35 (dd, J = 10.9. 6.8 Hz, 1H), 3.09-3.03 (m, 1H), 2.65 (dd, J = 14.4, 6.0 Hz, 1H), 2.50 (dd, J = 14.4, 7.4 Hz, 1H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 143.7 (C), 139.7 (CH), 139.2 (C), 130.8 (CH), 129.3 (CH), 129.2 (CH), 121.0 (CH), 76.8 (C), 66.7 (CH2), 53.8 (CH), 33.0 (CH2). ESI-HRMS calcd for C25H26N30+, (M+H)+, 384.2071, found 384.2068. [0067] (2S)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]-3-[l- (triphenylmethyl)-lH-imidazol-4-yl]propan-l-ol or (2S)-2-[({4-amino-5H-pyrrolo[3,2- d]pyrimidin-7-yl} methyl)amino] -3 – [ 1 -(triphenylmethyl)- 1 H-imidazol-5-yl]propan- 1 -ol (P.3). Compound P.2 (0.200 g, 0.52 mmol), 9-deazaadenine (0.070 g, 0.52 mmol) and aq. formaldehyde solution (37%, 0.051 mL, 0.68 mmol) were heated at 70 C in tert-butanol (3 mL) forl6 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (10% 7M NH3/MeOH-CHCl3) to give P.3 as a colourless foam (0.101 g, 37%). XH NMR (500 MHz, CD3OD): delta 8.03 (s, 1H), 7.39 (s, 1H), 7.35 (d, J = 1.3 Hz, 1H), 7.33-7.29 (m, 9H), 7.12-7.08 (m, 6H), 6.75 (d, J = 1.2 Hz, 1H), 3.96 (d, J = 13.7 Hz, 1H), 3.93 (d, J = 13.6 Hz, 1H), 3.61 (dd, J = 1 1.3, 4.8 Hz, 1H), 3.49 (dd, J = (0111) I I.3, 6.1 Hz, 1H), 3.02-2.97 (m, 1H), 2.72 (dd, J = 14.5, 6.5 Hz, 1H), 2.69 (dd, J = 14.5, 6.7 Hz, 1H). C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 152.0 (C), 150.8 (CH), 146.6 (C), 143.7 (C x 3), 139.5 (CH), 139.2 (C), 130.8 (CH), 129.24 (CH), 129.20 (CH), 128.9 (CH), 121.2 (CH), 115.4 (C), 114,8 (C), 76.8 (C), 64.3 (CH2), 59.4 (CH), 41.3 (CH2), 30.7 (CH2). ESI-HRMS calcd for C32H32 70+, (M+H)+, 530.2663, found 530.2666. [0068] (2S)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]-3-(lH- imidazol-4-yl)propan-l-ol (PA). Trifluoroacetic acid (0.6 mL, 8 mmol) was added to a stirred solution of P.3 (0.100 g, 0.19 mmol) and triethylsilane (0.090 mL, 0.57 mmol) in CH2CI2 (3 mL). After 2 h, the solvent was evaporated and the residue dissolved in MeOH and the solvent evaporated (3 x). The residue was again dissolved in MeOH, silica gel added and the solvent evaporated. Flash chromatography on silica gel (CHCl3-MeOH-28% aq. NH4OH, 7:2.5:0.5) gave P.4 as a colourless gum which crystallized on standing (0.050 g, 92%). XH NMR (500 MHz, CD3OD): delta 8.14 (s, 1H), 7.52 (d, J= 0.9 Hz, 1H), 7.42 (s, 1H), 6.80 (s, 1H), 4.01 (d, J= 13.6 Hz, 1H), 3.98 (d, J= 13.6 Hz, 1H), 3.63 (dd, J= 11.3, 4.7 Hz, 1H), 3.50 (dd, (0113) J = 11.3, 5…

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2227-98-7 , The common heterocyclic compound, 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0084] (2S)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]undecan- l-ol (U.2). Compound U.l (0.310 g, 0.947 mmol) was dissolved in MeOH (4 mL) and aq. hydrochloric acid (36%, 1 mL) added. After 15 min the solvent was evaporated to a colourless solid that was dissolved in a 4: 1 mixture MeOH-CHCi3, neutralized with Amberlyst A21 resin then passed through a short column of the same resin and eluted with 4: 1 MeOH-CHCl3. The fractions containing product were evaporated to a yellow oil that was dissolved in tert-butanol (4 mL) then 9-deazaadenine (0.127 g, 0.95 mmol) and aq. formaldehyde solution (37%, 0.085 mL, 1.10 mmol) were added and the mixture was stirred at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (gradient of 5 – 15% 7M NH3/MeOH in CHC13) to give U.2 as a colourless solid (0.135 g, 43%). XH NMR (500 MHz, 1: 1 CD3OD-CDCI3): delta 8.20 (s, 1H), 7.40 (s, 1H), 3.96 (s, 1H), 3.73 (dd, J = 11.4, 3.9 Hz, 1H), 3.50 (dd, J = 11.4, 6.6 Hz, 1H), 2.74-2.69 (m, 1H),1.55-1.39 (m, 2H), 1.35-1.21 (m, 14H), 0.89 (t, J= 7.0 Hz, 3H). 13C NMR (125.7 MHz, 1 : 1 CD3OD-CDCI3, centre lines delta 49.0 and delta 78.3): delta 151.2 (C), 150.2 (CH), 146.0 (C), 128.1 (CH), 115.0 (C), 114.2 (C), 63.6 (CH2), 59.0 (CH), 40.7 (CH2), 32.5 (CH2), 31.6 (CH2), 30.4 (CH2), 30.1 (2 x CH2), 29.9 (CH2), 26.8 (CH2), 23.2 (CH2), 14.3 (CH3). ESI-HRMS calcd for Ci8H32N50+, (M+H)+, 334.2602, found 334.2605.

The synthetic route of 2227-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2227-98-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

Example 18.4: (+/-)-c/s-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine (34); Formaldehyde (35 muL, 0.4 mmol, 37 wt% solution in water) followed by 9-deazaadenine (52 mg, 0.4 mmol) are added to a solution of 33 (32 mg, 0.3 mmol) in 1 ,4-dioxane (1 ml.) and water (1 ml_). The reaction mixture is stirred at room temperature for 68 h, absorbed onto silica and eluted down a silica column using a gradient 10 – 50% (7 N NH3 in MeOH) in CH2CI2. The crude product is collected, concentrated and subjected to flash chromatography (5 : 4.9 : 0.1 then 5 : 4.8 : 0.2, CH2CI2 : MeOH : 28% aq. NH4OH) to afford 34 as an off-white solid (45 mg, 62%). 1H NMR (500 MHz, CD3OD): delta = 8.16 (s, 1H), 7.49 (s, 1H), 4.20 (td, J = 5.8, 3.3 Hz, 1H), 3.89 (s, 2H), 3.17 (dd, J = 10.9, 5.5 Hz, 1 H), 2.95 (dd, J = 9.4, 7.5 Hz, 1H), 2.57 (dd, J = 10.9, 3.3 Hz, 1 H), 2.41 (t, J = 9.9 Hz, 1H), 2.00 – 1.92 (m, 1H), 1.61 – 1.53 (m, 1H), 1.38 – 1.28 (m, 1 H) and 0.92 ppm (t, J = 7.5 Hz, 3H). 13C NMR (125 MHz, CD3OD): delta = 152.1 , 151.0, 147.0, 130.1 , 115.1 , 112.7, 72.5, 63.0, 58.3, 49.4, 46.6, 21.4 and 13.2 ppm. ESI-HRMS for C13H20N5O [MH]+ calcd, 262.1668; found, 262.1663.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED; EVANS, Gary Brian; LONGSHAW, Alistair Ian; SCHRAMM, Vern L.; TYLER, Peter, Charles; WO2011/8110; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 2227-98-7

[0035] Example A. Synthesis of 2-[({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7- yljmethyl) amino] ethan-l-ol (A.1). (0059) (0060) [0036] 2-[ ({4-Amino-5H-pyrrolo[3, 2-dJpyrimidin- 7-yl }methyl) amino] ethan-l-ol (A.1). 2-Aminoethanol (0.099 mL, 1.64 mmol), 9-deazaadenine (0.220 g, 1.64 mmol) and aq. formaldehyde solution (37%, 0.15 mL, 1.99 mmol) were stirred together in tert-butanol (3 mL) at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue purified by chromatography on silica gel (CHCl3-MeOH-28% aq.NH4OH, 70:25:5). Fractions containing product were evaporated and the residue chromatographed again on silica gel (2-PrOH-28% aq. NH4OH, 92:8) to give A.1 as a colourless solid (0.101 g, 30%). NMR (500 MHz, CD3OD): delta 8.16 (s, 1H), 7.47 (s, 1H), 3.95 (s, 2H), 3.68 (t, J = 5.6 Hz, 2H), 2.78 (t, J = 5.6 Hz, 2H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 152.1 (C), 150.9 (CH), 146.6 (C), 129.0 (CH), 1 15.4 (C), 114.4 (C), 61.6 (CH2), 51.6 (CH2), 43.4 (CH2). ESI-HRMS calcd for C9H14N50+, (M+H) 208.1 193, found 208.1 192.

With the rapid development of chemical substances, we look forward to future research findings about 2227-98-7.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2227-98-7 ,Some common heterocyclic compound, 2227-98-7, molecular formula is C6H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

9-Deazaadenine [20] (1.49 g, 1.1 equiv), and then formaldehyde (aq, 37 mass%, 1.56 mL, 2 equiv) were added to a solution of amine 46 [21] (2.38 g, 10.1 mmol) in EtOH (20 mL) and H2O (10 mL). The resulting suspension was warmed to 60 C and stirred for 2 h. Silica gel (10 g) was added, solvents evaporated and the resulting solid purified by chromatography (10% 7 N NH3 in MeOH – CHCl3) to afford the title compound 47 (2.00 g, 52%) as a white solid. 1H NMR(CD3OD, 500 MHz) delta 8.17 (s, 1H), 7.46 (s, 1H), 7.33-7.17 (m, 5H), 3.90(dd, J = 11.8, 4.3 Hz, 2H), 3.80 (s, 2H), 3.60 (s, 2H), 3.53 (dd, J = 11.8,7.3 Hz, 2H), 2.42 (d, J = 7.5 Hz, 2H), 2.02-1.95 (m, 1H), 1.32 (s, 3H),1.20 (s, 3H). 13C NMR (d4-MeOH, 126 MHz) delta 152.0, 150.8, 147.2,141.0, 130.0, 129.7, 129.2, 127.9, 115.2, 113.8, 99.2, 64.1, 60.2, 53.6,48.6, 33.8, 25.4, 23.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2227-98-7, its application will become more common.

Reference:
Article; Mason, Jennifer M.; Yuan, Hongling; Evans, Gary B.; Tyler, Peter C.; Du, Quan; Schramm, Vern L.; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 793 – 809;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1 -((4RS, 5RS)-2,2-dimethyM-(methylthiomethyl)-1 ,3-dioxan-5-yl)-lambda/- methylmethanamine (30 mg, 137 mumol) in dioxane (2 mL) and water (0.5 mL) was added 9-deazaadenine (27.5 mg, 205 mumol) and 37% aqueous formaldehyde (15.86 mul,205 mumol). The reaction mixture was heated at 85 0C for 15 mins and then cooled and7N NH3ZMeOH (2.5 mL) was added. The solution was allowed to stand at RT for 3 days and concentrated to dryness. Chromatography (10% 7N NH3/MeOH in CH2CI2) gave 7-(((((4RS,5RS)-2,2-dimethyM-(methylthiomethyl)-1 ,3-dioxan-5- yl)methyl)(methyl)amino)methyl)-5H-pyrrolo[3,2-cdpyrimidin-4-amine (34 mg, 93 mumol,68 % yield) as a syrup. 1H NMR (CD3OD) delta 8.16 (1H, s); 7.45 (1H, s); 3.86 (1H, dd, J= 5.2, 11.9 Hz); 3.73-3.58 (3H, m); 3.52 (1 H1 dd, J = 10.6, 11.7 Hz); 2.79 (1 H, dd, J =2.5, 14.0 Hz); 2.53 (1H, dd, J = 7.1, 14.0 Hz); 2.32 (1H, dd, J = 5.5, 12.7 Hz); 2.24 (3H, s); 2.16 (1H, dd, J = 8.1 , 12.4 Hz); 2.06 (3H, s); 2.03-1.96 (1H, m); 1.36 (3H, s); 1.31(3H. s). 13C NMR (CD3OD) delta 152.6, 151.4, 147.8, 130.6, 115.7, 113.4, 100.1 , 75.9,64.7, 57.3, 52.4, 43.6, 39.3, 38.3, 29.9, 20.4, 17.4.

According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; WO2008/30118; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0075] (3R,4S)-l-({4-Amino-5R^yrrolof3,2-dJpyrimidin-7-yl}methyl)-4-f(pyridin-2- ylthio)methyl]pyrrolidin-3-ol (24). Compound 23 (0.171 g, 0.55 mmol) was dissolved in MeOH (4 mL) and aq. hydrochloric acid (36%, 1.5 mL) added. After 15 min the solvent was evaporated to yield a colourless gum that was dissolved in MeOH (10 mL), neutralized with Amberlyst A21 resin then passed through a short column of the same resin eluted with MeOH. The solvent was evaporated and the residue dissolved in a mixture of EtOH (4 mL) and H20 (2 mL) to which were added aq. formaldehyde solution (37%, 0.08 mL, 1 mmol) and 9-deazaadenine (0.096 g, 0.72 mmol). The mixture was heated at 70 C for 16 h and silica gel was added to absorb all the solvent then the solvent was evaporated and the residue purified by chromatography on silica gel (gradient of 0 – 7% aq. NH4OH (28%) in 2-PrOH). The fractions containing product were evaporated and the residue further chromatographed on silica gel (CHC13-7M NH3/MeOH, 85: 15) to afford 24 as a colourless solid (0.087 g, 44%). XH NMR (500 MHz, 1 : 1 CD30D-CDC13): delta 8.34 (ddd, J = 5.0. 1.8, 0.9 Hz, 1H), 8.19 (s, 1H), 7.54 (ddd, J = 9.7, 7.7, 1.9 Hz, 1H), 7.41 (s, 1H), 7.23 (dt, J = 8.2, 0.9 Hz, 1H), 7.03 (ddd, J= 7.3, 5.0, 0.9 Hz, 1H), 4.07 (ddd, J= 6.4, 3.9, 3.9 Hz, 1H), 3.85 (d, J= 13.5 Hz, 1H), 3.81 (d, J= 13.4 Hz, 1H), 3.37-3.34 (m, 1H + residual deuterated solvent), 3.15 (dd, J= 13.1, 8.2 Hz, 1H), 3.10-3.06 (m, 1H), 2.87 (dd, J = 10.4, 6.4 Hz, 1H), 2.74 (dd, J = 10.4, 3.9 Hz, 1H), 2.41-2.33 (m, 2H). 13C NMR (125.7 MHz, 1 : 1 CD3OD-CDC centre lines delta 49.0 and delta 78.3): delta 159.8 (C), 151.2 (C), 150.4 (CH), 149.7 (CH), 146.5 (C), 137.2 (CH), 129.1 (CH), 123.0 (CH), 120.4 (CH), 1 14.7 (C), 1 12.2 (C), 76.3 (CH), 61.9 (CH2), 58.4 (CH2), 48.7 (CH2), 47.9 (CH), 33.5 (CH2). ESI-HRMS calcd for Ci7H21N6OS+, (M+H)+, 357.1493, found 357.1485.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; CALLAGHAN INNOVATION RESEARCH LIMITED; SCHRAMM, Vern, L.; WANG, Shanzhi; HAAPALAINEN, Antti, Marko; EVANS, Gary, Brian; FURNEAUX, Richard, Hubert; CLINCH, Keith; TYLER, Peter, Charles; GULAB, Shivali, Ashwin; WO2014/25842; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 2227-98-7

[0077] (2S)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]heptan-l- ol (S.2). Compound S.l (0.358 g, 1.32 mmol) was dissolved in MeOH (4 mL) and aq. hydrochloric acid (36%, 1 mL) added. After 15 min the solvent was evaporated to a colourless solid that was dissolved in MeOH (10 mL), neutralized with Amberlyst A21 resin then passed through a short column of the same resin and eluted with MeOH. The fractions containing product were evaporated to an oily residue that was dissolved in tert-butanol (4 mL) then 9-deazaadenine (0.177 g, 1.32 mmol) and aq. formaldehyde solution (0.12 mL, 1.59 mmol) were added and the mixture stirred at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (gradient of 5 – 15% 7M NH3/MeOH in CHC13) to give S.2 as a colourless solid (0.122 g, 33%). NMR (500 MHz, CD3OD): delta 8.16 (s, 1H), 7.47 (s, 1H), 3.64 (dd, J = 1 1.2, 4.5 Hz, 1H), 3.48 (dd, J = 11.2, 6.5 Hz, 1H), 2.68-2.64 (m, 1H), 1.52-1.38 (m, 2H), 1.32-1.17 (m, 6H), 0.86 (t, J = 7.1 Hz, 3H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 152.1 (C), 150.8 (CH), 146.6 (C), 129.0 (CH), 1 15.4 (C), 1 14.8 (C), 64.4 (CH2), 59.2 (CH), 41.2 (CH2), 33.1 (CH2), 32.0 (CH2), 26.8 (CH2), 23.6 (CH2), 14.4 (CH3). ESI-HRMS calcd for Ci4H24N50+, (M+H)+, 278.1976, found 278.1974.

With the rapid development of chemical substances, we look forward to future research findings about 2227-98-7.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2227-98-7, Adding some certain compound to certain chemical reactions, such as: 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine,molecular formula is C6H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2227-98-7.

[0088] (2R)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]-3- (pyrazin-2-ylsulfanyl)propan-l-ol (V.2). Compound V.l (0.220 g, 0.68 mmol) was dissolved in CH2CI2 (8 mL) and trifluoroacetic acid (2 mL) added. After 2 h the solvent was evaporated and the residue dissolved in MeOH (10 mL) and neutralized with Amberlyst A21 resin then passed through a short column of the same resin and eluted with MeOH. The fractions containing product were evaporated to a yellow gum that was dissolved in tert-butanol (4 mL) then aq. formaldehyde solution (37%, 0.061 mL, 0.81 mmol) and 9-deazaadenine (0.091 g, 0.68 mmol) were added and the mixture heated at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (gradient of 10 – 15% 7M NH3/MeOH in CHCI3) to give V.2 as a colourless solid (0.055 g, 25%). XH NMR (500 MHz, CD3OD): delta 8.35 (d, J = 1.5 Hz, 1H), 8.28 (dd, J = 2.6, 1.7 Hz, 1H), 8.14 (d, J = 2.1 Hz, 1H), 8.12 (s, 1H), 7.43 (s, 1H), 4.05 (d, J = 13.9 Hz, 1H), 4.02 (d, J = 13.8 Hz, 1H), 3.74 (dd, J = 11.3, 4.9 Hz, 1H), 3.64 (dd, J = 11.3, 5.5 Hz, 1H), 3.39-3,31 (m, 2H + residual deuterated solvent), 3.01-2.97 (m, 1H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 158.2 (C), 152.0 (C), 150.8 (CH), 146.5 (C), 145.2 (CH), 144.6 (CH), 140.3 (CH), 129.0 (CH), 115.4 (C), 114.7 (C), 63.7 (CH2), 58.4 (CH), 41.4 (CH2), 31.6 (CH2). ESI-HRMS calcd Ci4H18N7OS+ (M+H)+, 332.1289, found 332.1287.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia