The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 22276-95-5
N,O-Bis(trimethylsilyl)acetamide (BSA, 0.56 mL, 2.27 mmol) was added to a stirred suspension of 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (480 mg, 2.06 mmol) in dry acetonitrile (15 mL). After stirring at rt for 10 min, 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d-ribofuranose (1.16 g, 2.31 mmol) was added, followed by the addition of trimethylsilyl trifluoromethanesulfonate (0.41 mL, 2.25 mmol). The reaction mixture was stirred at rt for 15 min, after which the flask was transferred to a preheated 80 C oil bath. After stirring for 1 h at 80 C, the reaction mixture was cooled to rt and diluted with EtOAc (75 mL). The organic phase was sequentially washed with aqueous saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated under reduced pressure to afford the crude nucleoside. Purification by flash column chromatography (silica gel, 20-100% EtOAc/hexanes gradient) provided (1) as a colorless foam (870 mg, 63%). TLC (silica gel, hexanes/ethyl acetate 3:1): Rf = 0.45. LRMS (ESI): 677.3, 675.2 and 673.2 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 22276-95-5.
Reference:
Article; Yu, Wenyu; Smil, David; Li, Fengling; Tempel, Wolfram; Fedorov, Oleg; Nguyen, Kong T.; Bolshan, Yuri; Al-Awar, Rima; Knapp, Stefan; Arrowsmith, Cheryl H.; Vedadi, Masoud; Brown, Peter J.; Schapira, Matthieu; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1787 – 1794;,
Pyrimidine | C4H4N2 – PubChem,
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