Category: 2240-25-7

Adding a certain compound to certain chemical reactions, such as: 2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2240-25-7, blongs to pyrimidines compound. Application In Synthesis of 4-Amino-5-bromopyrimidin-2(1H)-one

A mixture of compound 5-bromocytosine (150 g, 789 mmol, 1.00 equiv) and ethyl 3- bromo-2-oxo-propanoate (385 g, 1.97 mol, 247 mL, 2.50 equiv) in AcOH (1.5 L) was stirred at 120 C for 2 h. The crude 1H NMR spectrum indicated that the reaction was complete. Three batches were concentrated to provide a residue that was triturated with MTBE (3 L) and filtered. The filter cake was washed with water (1 L x 4) and dried to afford ethyl 8-bromo-5-oxo-5, 6- dihydroimidazo[l, 2-c]pyrimidine-2-carboxylate (300 g, 1.05 mol, 44.3% yield) as a brown solid. 1H NMR (400MHz, DMSO-d6) d 12.47 – 11.64 (m, 1H), 8.33 (s, 1H), 8.06 (s, 2H), 7.73 (s, 1H), 4.31 (q, 7= 7.1 Hz, 2H), 1.32 (t, J= 7.1 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2240-25-7, its application will become more common.

Reference:
Patent; MIRATI THERAPEUTICS, INC; MARX, Matthew, Arnold; LEE, Matthew, Randolph; BOBINSKI, Thomas, P.; BURNS, Aaron, Craig; ARORA, Nidhi; CHRISTENSEN, James, Gail; KETCHAM, John, Nichael; (225 pag.)WO2019/152419; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2240-25-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-25-7, name is 4-Amino-5-bromopyrimidin-2(1H)-one, molecular formula is C4H4BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromocytosine (95g, 0.5 mol), saturated sodium carbonate solution 200mL, 100 mL of dioxane was added the reaction flask was cooled to 10-15 °C dropwise loading fluorenylmethoxycarbonyl chloride (155.2g, 0.6mol mixed solu tion) and I00mL dioxane, the addition was complete, the reaction was warmed to room temperature and 3h, filtered, and the filter cake water (50mLX 2) washing and drying to give N- Fmoc-5-bromocytosine (196.7g , 95.4percent).

According to the analysis of related databases, 2240-25-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Xianfeng Technologies Co., Ltd; CHEN, XIAOPING; YAO, FUYOU; LU, WEI; XIAO, MUJIE; GAO, FEIFEI; (6 pag.)CN103819412; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2240-25-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-25-7, name is 4-Amino-5-bromopyrimidin-2(1H)-one. A new synthetic method of this compound is introduced below.

To a solution of 9 (1 g, 5.26 mmol) in DMF (10 mL) was added 40%chloroacetaldehyde (1.24 g, 6.32 mmol) at rt. The reaction mixture wasstirred at 100 C for 10 h. The reaction mixture was diluted with H2O(20 mL) and the white precipitate was filtered and washed with water.The solid was then dried under reduced pressure to give the titlecompound (0.73 g, 64.8% yield). 1H NMR (300 MHz, DMSO-d6) delta 11.92(s, 1H), 7.89 (d, J=1.0 Hz, 1H), 7.65 (s, 1H), 7.42 (d, J=1.0 Hz, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Article; Yang, Yifei; Chen, Pan; Zhao, Leilei; Zhang, Fangqing; Zhang, Bing; Xu, Changliang; Zhang, Huibin; Zhou, Jinpei; Bioorganic Chemistry; vol. 90; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Amino-5-bromopyrimidin-2(1H)-one, blongs to pyrimidines compound. Safety of 4-Amino-5-bromopyrimidin-2(1H)-one

EXAMPLE 694-amino-5-(2-(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)ethylamino)pyrimidin-2(1H)-one 40A solid mixture of 34 (100 mg, 0.306 mmol) and 5-bromocytosine (58 mg, 0.305 mmol) was heated at 150¡ã C. for 4 hours. After the reaction had cooled to room temperature, the product was purified by preparative HPLC to give the title compound 40 as the formate salt in 8.4percent yield (11 mg). 1H NMR (DMSO-d6/D2O) delta (ppm): 8.31 (s, 1H), 8.15 (s, 1H), 8.11 (s, 1H), 6.62 (s, 1H), 5.85 (d, 1H, J=5.6 Hz), 4.70 (dd, 1H, J=5.2, 5.6 Hz), 4.13 (m, 1H), 4.00 (m, 1H), 2.90 (m, 4H), 2.65 (m, 2H). MS calc 435.46; found 436 (MH)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; METHYLGENE INC.; US2008/132525; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia