Category: 2244-11-3

Jordan, Brian J.; Carroll, Joseph B.; Xu, Hao; Erdogan, Belma; Lee, Lisa; Cheng, Lily; Tiernan, Chris; Cooke, Graeme; Rotello, Vincent M. published the artcile< Site isolated redox behavior in flavin functionalized random polystyrene copolymers>, HPLC of Formula: 2244-11-3, the main research area is flavin functionalized random polystyrene copolymer.

A model system has been developed to investigate the individual redox behaviors of flavin derivatives appended onto random polystyrene copolymers through “”click”” chem. procedures. The results indicate that flavin units attached to the polymers exhibit site isolated behavior vs. free flavin, yielding unique fluorescent materials with electrochem. tunable associations upon addition of complementary diamidopyridine functionality.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about Cyclic voltammetry. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, HPLC of Formula: 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Allehyani, Basmah H.; Elroby, Shaaban A.; Aziz, Saadullah G.; Hilal, Rifaat H. published the artcile< Protonation and deprotonation enthalpies of alloxan and implications for the structure and energy of its complexes with water: a computational study>, Product Details of C4H4N2O5, the main research area is alloxan water complex hydrogen bond DFT calculation; DFT calculations; alloxan; dipolar alloxan–water interaction; gas phase acidities; hydrogen bond; trajectory dynamics simulation.

The optimized geometries, harmonic vibrational frequencies, and energies of the structures of monohydrated alloxan were computed at the DFT/ωB97X-D and B3LYP/6-311++G** level of theory. Results confirm that the monohydrate exists as a dipolar alloxan-water complex which represents a global min. on the potential energy surface (PES). Trajectory dynamics simulations show that attempt to reorient this monohydrate, to a more favorable orientation for H-bonding, is opposed by an energy barrier of 25.07 kJ/mol. Alloxan seems to prefer acting as proton donor than proton acceptor. A marked stabilization due to the formation of N-H-OH2 bond is observed The concerted proton donor-acceptor interaction of alloxan with one H2O mol. does not increase the stability of the alloxan-water complex. The proton affinity of the O and N atoms and the deprotonation enthalpy of the NH bond of alloxan are computed at the same level of theory. Results are compared with recent data on uracil, thymine, and cytosine. The intrinsic acidities and basicities of the four pyrimidines were discussed. Results of the present study reveal that alloxan is capable of forming stronger H-bonds and more stable cyclic complex with water, yet it is of much lower basicity than other pyrimidines.

Journal of Biomolecular Structure and Dynamics published new progress about Atomic charge. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Product Details of C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Carvalho, Vinicius F.; Barreto, Emiliano O.; Arantes, Ana Carolina S.; Serra, Magda F.; Ferreira, Tatiana Paula T.; Jannini-Sa, Yago A. P.; Hogaboam, Cory M.; Martins, Marco A.; Silva, Patricia M. R. published the artcile< Diabetes downregulates allergen-induced airway inflammation in mice>, Application of C4H4N2O5, the main research area is allergen airway inflammation asthma diabetes mellitus.

Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on allergic airway inflammation in a model of exptl. asthma in mice. Diabetes was induced by i.v. injection of alloxan into 12 h-fasted A/J mice, followed by s.c. sensitization with ovalbumin (OVA) and aluminum hydroxide (Al(OH)3), on days 5 and 19 after diabetes induction. Animals were intranasally challenged with OVA (25 μg), from day 24 to day 26. Alloxan-induced diabetes significantly attenuated airway inflammation as attested by the lower number of total leukocytes in the bronchoalveolar lavage fluid, mainly neutrophils and eosinophils. Suppression of eosinophil infiltration in the peribronchiolar space and generation of eosinophilotactic mediators, such as CCL-11/eotaxin, CCL-3/MIP-1α, and IL-5, were noted in the lungs of diabetic sensitized mice. In parallel, reduction of airway hyperreactivity (AHR) to methacholine, mucus production, and serum IgE levels was also noted under diabetic conditions. Our findings show that alloxan diabetes caused attenuation of lung allergic inflammatory response in A/J mice, by a mechanism possibly associated with downregulation of IgE antibody production

Mediators of Inflammation published new progress about Allergens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Application of C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kakkar, Rita; Sarma, Bhupendra K.; Katoch, Vandana published the artcile< Theoretical study of the mechanism of proton transfer in tautomeric systems: alloxan>, Synthetic Route of 2244-11-3, the main research area is alloxan proton transfer mechanism MNDO AM1 MO.

Semiempirical SCF-MO studies of tautomerism in alloxan preclude the possibility of direct proton transfer in the gas phase due to the strain in the four-centered transition state, in which the proton being transferred is forced to come close to the pos. charged carbon atom at the opposite corner of the four-membered ring. However, in aqueous solution, the activation barrier reduces appreciably, not only due to reduction in strain, but also due to charge separation in the transition state, which is stabilized due to ionic resonance. The N-H bond is almost broken, while the O-H bond is only partially formed in the transition state. The other stabilizing effect in aqueous solution is due to bulk solvent dielec. effects, which stabilize the transition state to a greater extent due to its higher dipole moment. Although the transition states for proton transfer to the neighboring oxygen atoms on either side have comparable energies, as the mechanisms of proton transfer leading to the formation of the 2-hydroxy and 4-hydroxy tautomers are similar, bulk solvent effects are larger in the latter due to the higher dipole moment of the transition state. The reason is the almost complete separation of the two entities, i.e. the alloxan anion and the hydronium ion in the latter case, indicating that in this case a dissociative mechanism of the kind encountered in acid-base equilibrium is operating.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about Activation energy (tautomerization). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Synthetic Route of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Eweg, Jan K.; Mueller, Franz; Bebelaar, Dick; Van Voorst, Joop D. W. published the artcile< Spectral properties of isoalloxazines in the vapor phase>, Reference of 2244-11-3, the main research area is alloxazine vapor fluorescence spectra; isoalloxazine vapor fluorescence spectra.

Spectral properties of two alloxazine and six isoalloxazine derivatives were determined at high temperatures in the vapor phase and compared with spectra observed in solution Vapor phase spectrometry gave primary photophys. properties of the isolated chromophore. Fluorescence lifetimes in the vapor phase were <0.5-18 ns. An intramol. complex existed between the isoalloxazine moiety and its aliphatic side chain carrying a polar hydroxyl group. Direct photodissociation of the mol. in its 1st electronically excited singlet state was not very probable. Photochemistry and Photobiology published new progress about Fluorescence. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Reference of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Elston, C.; Holmes, D. E.; Moorthy, P. N.; Pleticha-Lansky, R. published the artcile< Effects of γ-radiation on alloxantin. Polarographic, oscillopolarographic, and electron spin resonance studies>, Computed Properties of 2244-11-3, the main research area is alloxantin irradiation ESR.

Polarographic and oscillopolarographic investigation of the effects of γ-radiation on an aqueous solution of alloxantin showed the formation of alloxan, parabanic acid, and oxaluric acid. In addition an unidentified product X was observed, exhibiting cathodic wave at E1/2≈-1 V on polarography in acetate buffer of pH 3.6. This product is due probably to a higher oxidation state of alloxan and undergoes polarographic reduction at more neg. potentials than parabanic acid. ESR signals have been observed in γ-irradiated polycrystalline alloxantin-dihydrate, alloxan-monohydrate, dialuric acid, and parabanic acid. The G-values for the formation of the radicals responsible for these signals were determined Signals were also observed from organic free radicals formed through the reactions of electrons induced in irradiated H2SO4 ices containing alloxantin and alloxan.

International Journal for Radiation Physics and Chemistry published new progress about ESR (electron spin resonance). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Computed Properties of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Rai, Roopali; Pandey, Pramod S. published the artcile< Comparative binding study of steroidal adenine with flavin and uracil derivatives>, Product Details of C4H4N2O5, the main research area is steroidal adenine flavin uracil derivative preparation.

A comparative binding study of a steroidal adenine derivative based on lithocholic acid with N10-benzylisoalloxazine (flavin) and N1-iso-propyluracil has been described.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Product Details of C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Makita, Yoshimasa; Kawaguchi, Shin-ichi; Fujiwara, Shin-ichi published the artcile< Characterization and antitumor activity of furazano[3,4-g]pteridine-2,4(1H,3H)-dione>, Product Details of C4H4N2O5, the main research area is furazanopteridinedione preparation antitumor crystal structure emission absorption spectra.

Structural characterization and properties of furazano[3,4-g]pteridine-2,4(1H,3H)-dione by X-ray crystal structure anal. was reported and evaluated for its antitumor activity. The IC50 value of furazano[3,4-g]pteridine-2,4(1H,3H)-dione was 172μM, as determined using HeLa cells.

Heterocycles published new progress about Absorption spectra. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Product Details of C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

John, Joyamma published the artcile< Evaluate the hypoglycemic effect of vinca rosea leaf extracts in alloxan induced diabetic rats>, HPLC of Formula: 2244-11-3, the main research area is allaxon induced diabetic Vinca rosea leaf extract hypoglycemic effect.

The present study was carried out to evaluate the antidiabetic activity of aqueous leaf extract of Vinca rosea. The aqueous extract at high dose (300mg/100g) body weight showed a significant hypoglycemic activity. Improvement in the body weight and water and food consumption is also observed after the treatment with herbal extract

International Journal of Science and Nature published new progress about Antidiabetic agents. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, HPLC of Formula: 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Trenker, Stefan; Grunenberg, Lars; Banerjee, Tanmay; Savasci, Goekcen; Poller, Laura M.; Muggli, Katharina I. M.; Haase, Frederik; Ochsenfeld, Christian; Lotsch, Bettina V. published the artcile< A flavin-inspired covalent organic framework for photocatalytic alcohol oxidation>, Formula: C4H4N2O5, the main research area is diethyl bis formylphenyl alloxazine covalent organic framework preparation; aryl aldehyde preparation; alc oxidation catalyst FEAx COF.

Herein, the construction and use of a novel COF (FEAx-COF) photocatalyst, inspired by natural flavin cofactors was reported. The functionality of the alloxazine chromophore incorporated into the COF backbone was retained and study the effects of this heterogenization approach by comparison with similar mol. photocatalysts. The integration of alloxazine chromophores into the framework significantly extended the absorption spectrum into the visible range, allowing for photocatalytic oxidation of benzylic alcs. to aldehydes RC(O)H [R = 4-MeC6H4, 4-MeOC6H4, 4-t-BuC6H4, 2-thienyl] even with low-energy visible light. In addition, the activity of the heterogeneous COF photocatalyst was less dependent on the chosen solvent, making it more versatile compared to mol. alloxazines. Finally, the use of oxygen as the terminal oxidant renders FEAx-COF a promising and green heterogeneous photocatalyst.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Formula: C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia