2244-11-3 | Page 2 of 3

Menova, Petra’s team published research in Advanced Synthesis & Catalysis in 2013 | 2244-11-3

Advanced Synthesis & Catalysis published new progress about Aromatic compounds, sulfoxides Role: SPN (Synthetic Preparation), PREP (Preparation). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Name: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Menova, Petra; Dvorakova, Hana; Eigner, Vaclav; Ludvik, Jiri; Cibulka, Radek published the artcile< Electron-Deficient Alloxazinium Salts: Efficient Organocatalysts of Mild and Chemoselective Sulfoxidations with Hydrogen Peroxide>, Name: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, the main research area is electron deficient alloxazinium salt organocatalyst Chemoselective Sulfoxidations LFER.

A series of substituted alloxazinium perchlorates has been prepared and tested as catalysts for the oxidation of sulfides to sulfoxides with hydrogen peroxide. The logarithms of the observed rate constants of thioanisole oxidation correlate with the Hammett σ constants of the substituents on the alloxazinium catalysts, as well as with their reduction potentials E0′ and their pKR+ values, representing the alloxazinium salt/pseudobase equilibrium The stronger the electron-withdrawing substituent, the more efficient is the alloxazinium catalyst. The alloxazinium salts with a cyano or trifluoromethyl group in position 8 proved to be the most efficient, operating at room temperature at small loadings, down to 0.1 mol,̂ achieving turnover number values of up to 640 and acceleration by a factor of 350 relative to the non-catalyzed oxidation The 8-cyanoalloxazinium perchlorate was evaluated as the best catalyst; however, due to its relatively good accessibility, the 8-(trifluoromethyl)alloxazinium perchlorate seems to be the catalyst of choice for sulfoxidations with hydrogen peroxide. It was successfully tested for the sulfoxidation of a series of aliphatic and aromatic sulfides on a preparative scale. It produced the corresponding sulfoxides in quant. conversions and with high isolated yields (87-98 %). No over-oxidation to sulfone was ever observed

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kashiwagi, Michio’s team published research in Nippon Kagaku Zasshi in 1966 | 2244-11-3

Nippon Kagaku Zasshi published new progress about ESR (electron spin resonance). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Related Products of 2244-11-3.

Kashiwagi, Michio published the artcile< Electron spin resonance of irradiated single crystals of alloxan monohydrate>, Related Products of 2244-11-3, the main research area is ALLOXAN IRRADIATED ESR; ESR IRRADIATED ALLOXAN.

X-ray irradiated single crystals of alloxan monohydrate were subjected to E.S.R. studies. Irradiation gives rise to radicals I by the abstraction of a hydroxyl group. The principal values of g-factors of the radicals are g1 = 2.0021, g2 = 2.0042, and g3 = 2.0060. The principal values of coupling constants with hydroxyl H are A1 = 3.1, A2 = -5.9, and A3 = -7.4 gauss. Spin ds. on the C and H atoms of •C-OH were evaluated from the 13C coupling constant Under the assumption of a planar structure for •C-OH and from consideration of the electronic structure of the radical, the directions of the principal values were concluded as follows. The directions of g1 and A2 are perpendicular to the radical plane, while that of g3 bisects the exterior angle of •COH. The direction of A1 is parallel to the OH bond.

Nippon Kagaku Zasshi published new progress about ESR (electron spin resonance). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Related Products of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Crocker, Leander’s team published research in Nanoscale Horizons in 2019 | 2244-11-3

Nanoscale Horizons published new progress about Antioxidants. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Category: pyrimidines.

Crocker, Leander; Koehler, Philipp; Bernhard, Patrick; Kerbs, Antonina; Euser, Tijmen; Fruk, Ljiljana published the artcile< Enzyme-inspired flavin-polydopamine as a biocompatible nanoparticle photocatalyst>, Category: pyrimidines, the main research area is flavin polydopamine biocompatibility nanoparticle photocatalyst.

A new approach aimed at designing an enzyme-inspired photocatalyst is presented that exploits the inherent photocatalytic activity of flavin and the facile polymerization of dopamine to afford hybrid cofactor-containing nanoparticles. The flavin-polydopamine system benefits from ease of synthesis, tunability in terms of size and activity, and excellent temporal control over the catalyzed reactions. This novel, versatile photocatalyst exhibits both photooxidation and photoreduction of chromogenic enzymic substrates. In addition, the prepared hybrid nanoparticles are shown to be non-toxic, paving the way to their use in a wider range of applications beyond green catalysis, such as antioxidant adjuvants to various therapeutic approaches.

Nanoscale Horizons published new progress about Antioxidants. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Suzuki, Haruka’s team published research in Chemistry – A European Journal in 2015 | 2244-11-3

Chemistry – A European Journal published new progress about Crystal structure. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Category: pyrimidines.

Suzuki, Haruka; Inoue, Ryo; Kawamorita, Soichiro; Komiya, Naruyoshi; Imada, Yasushi; Naota, Takeshi published the artcile< Highly Fluorescent Flavins: Rational Molecular Design for Quenching Protection Based on Repulsive and Attractive Control of Molecular Alignment>, Category: pyrimidines, the main research area is flavin fluorescence mol alignment quenching protection repulsive attractive control; flavins; fluorescence; hydrogen bonds; molecular design; steric hindrance.

Unprecedented intense fluorescent emission was observed for a variety of flavin compounds bearing a perpendicular cyclic imide moiety at the C7 position of an isoalloxazine platform. A series of alloxan-substituted flavins was prepared selectively by reduction of the corresponding N-aryl-2-nitro-5-alkoxyanilines with zinc dust and subsequent reaction with alloxan monohydrate in the presence of boric acid. Analogs bearing oxazolidine-2,4-dione functionality were obtained on methylation of the alloxan-substituted flavins with Me iodide and subsequent rearrangement in the presence of an inorganic base. The flavin compounds exhibit intense white-green fluorescent emission in the solution state under UV excitation at 298 K, with emission efficiencies Φ298 K greater than 0.55 in CH3CN, which are higher than the values for all reported flavin compounds under similar conditions. The highest Φ298 K value of 0.70 was obtained in CH3CN for isoalloxazine bearing C7-alloxan and N10-2,6-diisopropylphenyl groups. The temperature dependence of the emission intensities indicates that the pronounced emission properties at 298 K are attributable to the highly heat resistant properties towards emission decay with increasing temperature Mechanistic studies, including X-ray diffraction anal., revealed that the good emission properties and high heat resistance of the alloxan-substituted flavins are due to a synergetic effect of the associative nature of the C7-alloxan unit and the repulsive nature of the perpendicular bulky substituents at the C7 and N10 positions.

Chemistry – A European Journal published new progress about Crystal structure. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Oka, Yoshimi’s team published research in ACS Omega in 2017-06-30 | 2244-11-3

ACS Omega published new progress about Biological imaging. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Computed Properties of 2244-11-3.

Oka, Yoshimi; Shishino, Hisae published the artcile< Fluorescence Imaging of Disrupted Interfaces between Liquid-Ordered and Liquid-Disordered Domains by a Flavin-Labeled PNA Duplex>, Computed Properties of 2244-11-3, the main research area is fluorescence imaging interface liquid ordered disordered domain flavin PNA.

Lipid rafts and membrane-active peptides are attracting attention because they help understand basic membrane functions. In addition, the authors focus on flavoproteins playing some physiol. roles and explore the model compounds A new flavin probe, composed of palmitoylated peptide nucleic acid (PNA) and its complementary PNA labeled with flavin, targets the liquid-ordered (lo) microdomains and disrupts its interfaces to liquid-disordered (ld) microdomains of giant unilamellar vesicles and can be visualized by using confocal laser scanning microscopy. Surprisingly, as shown in time-lapse images, vesiculation and probe aggregations appear in the lo-ld interfaces, which leads to local disruption of the membrane. A possible interpretation of the data based on comparison with control experiments are discussed.

ACS Omega published new progress about Biological imaging. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Computed Properties of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

14 Sep 2021 News Extracurricular laboratory: Synthetic route of 2244-11-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 2244-11-3, Adding some certain compound to certain chemical reactions, such as: 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate,molecular formula is C4H4N2O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2244-11-3.

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.9 5-[2-(4′-Acetylbiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (15) 55% Yield, mp > 250 C (decomp. 235 C). 1H NMR delta 11.45 (s, 2H, NH), 8.05-8.08 (m, 4H), 7.90-7.93 (m, 4H), 7.31 (s, 1H, OH), 3.94 (s, 2H), 2.61 (s, 3H). Anal. % (C20H16N2O6) calculated: C 63.16, H 4.24, N 7.37; found C 63.30, H 4.43, N 7.44.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Synthetic Route of 2244-11-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds.5.1.2.12 5-[3-(Biphen-4-yl)-2-oxopropyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (19) 27% Yield, mp 173-5 C (decomp. 150 C). 1H NMR (acetone-d6) delta 10.24 (s, 2H, NH), 7.60-7.67 (m, 2H), 7.43-7.54 (m, 3H), 7.30-7.37 (m, 3H), 7.16-7.19 (m, 1H), 5.80 (s, 1H, OH), 3.30 (s, 2H), 2.14 (s, 2H). Anal. % (C19H16N2O5) calculated: C 64.77, H 4.58, N 7.95; found C 64.47, H 4.27, N 7.67.

Sources of common compounds: 2244-11-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, molecular formula is C4H4N2O5, molecular weight is 160.085, as common compound, the synthetic route is as follows.Product Details of 2244-11-3

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.10 5-[2-(4′-(N,N-Dimethylaminocarbonyl)biphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (17) 62% Yield, mp > 250 C 1H NMR delta 11.45 (s, 2H, NH), 8.05 (d, 2H, Jo = 8.3), 7.88 (d, 2H, Jo = 8.3), 7.81 (d, 2H, Jo = 8.3), 7.52 (d, 2H, Jo = 8.3), 7.32 (s, 1H, OH), 3.93 (s, 2H), 2.98 (s, 3H), 2.94 (s, 3H). Anal. % (C21H19N3O6) calculated: C 61.61, H 4.68, N 10.25; found C 61.22, H 4.94, N 10.49.

Extended knowledge of 2244-11-3

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H4N2O5, blongs to pyrimidines compound. Computed Properties of C4H4N2O5

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds. 5.1.2.2 5-[2-(4′-Methylbiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (8) 69% Yield, mp > 250 C 1H NMR delta 11.46 (s, 2H, NH), 8.02 (d, 2H, Jo = 8.7), 7.82 (d, 2H, Jo = 8.7), 7.65 (d, 2H, Jo = 8.4), 7.30 (d, 2H, Jo = 8.4), 7.31 (s, 1H, OH), 3.91 (s, 2H), 2.34 (s, 3H). Anal. % (C19H16N2O5) calculated: C 64.77, H 4.58, N 7.95; found C 64.56, H 4.60, N 7.82.

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.

The origin of a common compound about 2244-11-3

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.3 5-[2-(4′-Chlorobiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (9) 60% Yield, mp > 250 C 1H NMR delta 10.60 (s, 2H, NH), 7.81 (d, 2H, Jo = 8.3), 7.49 (d, 2H, Jo = 8.3), 7.40 (d, 2H, Jo = 8.4), 7.28 (d, 2H, Jo = 8.4), 6.83 (s, 1H, OH), 3.89 (s, 2H). Anal. % (C18H13ClN2O5) calculated: C 58.00, H 3.52, N 7.51; found C 57.96, H 3.67, N 7.49.

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.