Category: 2244-11-3

Adding a certain compound to certain chemical reactions, such as: 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, blongs to pyrimidines compound. Quality Control of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.6 5-[2-(4′-(Trifluoromethoxy)biphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (12) 69% Yield, mp > 250 C 1H NMR delta 11.46 (s, 2H, NH), 8.05 (d, 2H, Jo = 8.3), 7.84-7.90 (m, 4H), 7.49 (d, 2H, Jo = 8.3), 7.32 (s, 1H, OH), 3.93 (s, 2H). Anal. % (C19H13F3N2O6) calculated: C 54.04, H 4.55, N 6.63; found C 53.91, H 4.44, N 6.72.

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2244-11-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.8 5-[2-(4′-(Methylsulphonyl)biphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (14) 65% Yield, mp > 250 C 1H NMR delta 11.44 (s, 2H, NH), 7.91-8.10 (m, 8H), 7.31 (s, 1H, OH), 3.94 (s, 2H), 3.26 (s, 3H). Anal. % (C19H16N2O7S) calculated: C 54.80, H 3.87, N 6.73; found C 54.50, H 3.57, N 6.86.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows. 2244-11-3

EXAMPLE 54 3,4-Dihydro-4-(4-methoxyphenyl)-3-oxoquinoxaline 2-carboxyureide To a solution of N-(4-methoxyphenyl)benzene-1,2-diamine (9.0 g) in ethanol (150 ml) was added a solution of alloxan monohydrate (6.7 g) in water (150 ml) and the mixture was stirred for 30 minutes. The precipitate was filtered off and recrystallized from glacial acetic acid giving the title compound mp 236-238 C. Analysis: 60.5%C; 4.4%H; 16.8%N; Requires: 60.4%C; 4.1%H; 16.6%N.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Reference:
Patent; Fisons Limited; US4296114; (1981); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows. 2244-11-3

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds. 5.1.2.1 5-[2-(3′-Nitrobiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (7) 64% Yield, mp 246-8 C 1H NMR delta 11.46 (s, 2H, NH), 8.51 (s, 1H), 8.21-8.29 (m, 2H), 8.09 (d, 2H, Jo = 8.1), 7.96 (d, 2H, Jo = 8.1), 7.79 (t, 1H, Jo = 8.1), 7.33 (s, 1H, OH), 3.95 (s, 2H). Anal. % (C18H13N3O7) calculated: C 56.40, H 3.42, N 10.96; found C 56.28, H 3.37, N 10.68.

Statistics shows that 2244-11-3 is playing an increasingly important role. we look forward to future research findings about Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2244-11-3 , The common heterocyclic compound, 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, molecular formula is C4H4N2O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 34 5-Hydroxy-5-(1-methyl-3-indolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione Alloxan hydrate (1.6 g., 0.01 mole) 1-methylindole (1.3 g., 0.01 mole) and ethanol (50 ml.) was combined and the mixture refluxed for 0.5 hour, then concentrated to half-volume, diluted with water and the resulting product recovered by filtration [2.7 g., Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4342771; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia