Category: 22536-64-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22536-64-7, name is 2-Chloro-4-methoxy-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H7ClN2O

A mixture of tert-butyl 4-(4-hydroxyphenyl)piperazine- 1 -carboxylate (2.78 g, 10.0 mmol), 2-chloro-4-methoxy-6-methylpyrimidine (1.74 g, 11.0 mmol) and sodium carbonate (1.16 g, 11.0 mmol) in acetonitrile (10 mL) was heated to 80C and stirred for 20 hours under an N2 atmosphere. The reaction mixture was then cooled to rt. The resulting mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as a white solid (1.02 g, 25.5%). The compound was characterized by the following spectroscopic data:LC-MS (ESI, pos. ion) m/z: 401.2 [M + H] and?HNMR(400 MHz, CDC13) (ppm): 7.13 -7.11 (m, 2H), 6.96-6.92 (m, 2H), 6.27 (s, 1H), 3.84(s, 3H), 3.59 (t, J 4.8 Hz, 4H), 3.11 (t, J= 4.7 Hz, 4H), 2.33 (s, 3H), 1.48 (s, 9H).

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Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; CHENG, Changchung; WO2015/169180; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 22536-64-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22536-64-7, name is 2-Chloro-4-methoxy-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 8 4-Methoxy-6-methyl-2-(1,2,4-triazol-1-yl)-pyrimidine In anhydrous tetrahydrofuran, 159 mg of 2-chloro-4-methoxy-6-methylpyrimidine was substituted with 69 mg of 1,2,4-triazole. The reaction mixture was treated according to the procedure as in Example 5 to yield 92 mg of 4-methoxy-6-methyl-2-(1,2,4-triazol-1-yl)-pyrimidine, recrystallized from n-hexane, having a melting point of 142.5-143 C. NMR(CDCl3)delta: 2.53(1H,s), 4.07(1H,s), 6.57(1H,s), 8.13(1H,s), 9.20(1H,s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22536-64-7, 2-Chloro-4-methoxy-6-methylpyrimidine.

Reference:
Patent; Nissin Shokuhin Kabushiki Kaisha; US4849424; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia