Category: 23256-42-0

On April 1, 1981, Quintanilla Almagro, Eliseo published a patent.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 2-hydroxypropionate. And the patent contained the following:

Lactotrim (I) [23256-42-0], the title compound, was prepared by slow addition of 2-hydroxypropanoic acid to an EtOH suspension of 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, during constant agitation. The precipitate was dried under vacuum and controlled temperature The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to lactotrim, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ahonkhai, Ijeoma; Russell, A. D. published an article in 1979, the title of the article was Response of RP1+ and RP1- strains of Escherichia coli to antibacterial agents and transfer of resistance to Pseudomonas aeruginosa.SDS of cas: 23256-42-0 And the article contains the following content:

The sensitivity of strains of Escherichia coli, with and without the RP1 R-factor, to antibiotics and other antibacterial agents has been studied. RP1+ strains of E. coli were resistant to kanamycin [8063-07-8], carbenicillin [4697-36-3], and tetracycline [60-54-8], with resistance to the 1st 2 antibiotics being produced by destruction of the drugs. This resistance could be transfered to 2 strains of P. aeruginosa. The parent strain of Escherichia coli UB 1005, its 2 mutant strains (DC2 and DC3), and 2 of the strains with the RP1 R-factor showed a similar order of sensitivity to phenylmercuric nitrate [55-68-5], chlorhexidine diacetate [56-95-1], thiomersal [54-64-8], and HgCl2. Escherichia coli Strains DC2 and DC2 (RP1+) were the most sensitive to benzalkonium chloride and cetrimide [8044-71-1], RP1+ strains were more resistant than RP1- strains to a lysozyme-disodium EDTA mixture [75008-29-6], but treatment of the former strains with acriflavine rendered the cells more sensitive to the lytic system. There was no evidence that P. aeruginose (RP1+) strains possessed increased resistance to polymyxin B sulfate [1405-20-5] or to disinfectants, although they became somewhat less sensitive to lysozyme-EDTA. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).SDS of cas: 23256-42-0

The Article related to escherichia r factor antimicrobial agent, pseudomonas r factor antimicrobial agent, antibiotic escherichia r factor, bactericide escherichia r factor, Biochemical Interactions: Microbial Systems and other aspects.SDS of cas: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2017, Podesvova, Lucie; Huang, Huan; Yurchenko, Vyacheslav published an article.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the article was Inducible protein stabilization system in Leishmania mexicana. And the article contained the following:

Targeted regulation of protein levels is an important tool to investigate the role of proteins essential for cell function and development. In recent years, methods based on the Escherichia coli dihydrofolate reductase destabilization domain (ecDHFR DD) have been established and used in various cell types. ecDHFR DD destabilizes the fused protein of interest and causes its degradation by proteasomes, unless it is stabilized by a specific ligand, trimethoprim. In this work we developed an inducible protein stabilization system in Leishmania mexicana based on ecDHFR DD. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to protein stabilization system leishmania dihydrofolate reductase, leishmania mexicana, protein stabilization, trimethoprim, ecdhfr, Enzymes: Structure-Conformation-Active Site and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Grey, Daphne; Hamilton-Miller, J. M. T. published an article in 1977, the title of the article was Sensitivity of Pseudomonas aeruginosa to sulfonamides and trimethoprim and the activity of the combination trimethoprim: sulfamethoxazole.Computed Properties of 23256-42-0 And the article contains the following content:

P. aeruginosa strains from urinary infections were resistant or only moderately sensitive to sulfadiazine [68-35-9], sulfamethoxazole (I) [723-46-6], sulfadimidine [57-68-1], or trimethoprim lactate (II lactate) [23256-42-0], but a marked synergy between I and II was noted with the moderately sensitive strains. Thus, therapeutically attainable urinary levels of these drugs (which were ineffective individually) were quite inhibitory to P. aeruginosa when used in combination. The min. inhibitory concentrations of I and II when used in combination suggested that disks containing I and II at a 1:2 ratio would be more appropriate for determining the drug susceptibility of urinary pathogens than the usual 1:20 ratio. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to sulfonamide trimethoprim pseudomonas sensitivity, urine pseudomonas trimethoprim sulfamethoxazole, Biochemical Interactions: Microbial Systems and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Thirkell, D.; Blankson, M. published an article in 1981, the title of the article was The speciation of coliform genera from above and below a sewer outfall and their susceptibilities to antimicrobial agents.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

The occurrence of coliforms in a small water course increased by a factor of 36 below the outfall of a sewage treatment plant. Speciation of the bacteria from above and below the sewer outfall showed that Escherichia coli and Enterobacter species predominated. Drug-resistance levels were significant in microorganisms from both sampling sites, and the occurrence of a significant number of multiple-resistant microorganisms, particularly E. coli, is reported. Both E. coli and Enterobacter species from below the sewer outfall showed a statistically significant increase in resistance to ampicillin [69-53-4] as compared with isolates from above the outfall, and E. coli from below the outfall also showed a statistically significant increase in resistance to sulphamethoxazole [723-46-6]. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to coliform bacteria sewage antibiotic sensitivity, taxonomy coliform bacteria sewage, Biochemical Interactions: Microbial Systems and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hamilton-Miller, J. M. T.; Grey, Daphne published an article in 1975, the title of the article was Resistance to trimethoprim in klebsiellae isolated before its introduction.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

In vitro 6 of 12 strains of Klebsiella aerogenes or K. ozaenae were resistant to trimethoprim lactate (I lactate) [23256-42-0], whereas all 12 strains were resistant to sulfamethoxazole [723-46-6]. All of these 12 strains were isolated and freeze-dried (1961-64) prior to clin. use of I. Of the 6 I-resistant strains, 5 were also resistant to tetracycline, chloramphenicol, and streptomycin. No evidence was found for R-factor involvement in I resistance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to trimethoprim resistance klebsiella, sulfamethoxazole resistance klebsiella, Biochemical Interactions: Microbial Systems and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 7, 2010, Dong, Wei; Li, Xiaowen; Sun, Zhiliang published a patent.HPLC of Formula: 23256-42-0 The title of the patent was Long-acting antibacterial medicinal water-in-oil emulsion and its preparation method. And the patent contained the following:

The title emulsion is composed of water phase, oil phase, emulsifying agents and stabilizers. The oil phase is white oil 7# or 15#. The water-phase emulsifying agent is tween 80 and the oil-phase emulsifying agent is span 80. The emulsion is prepared by adding water-phase stabilizer into water at 40-45°, cooling to room temperature, dissolving antibacterial drug, adding tween 80, stirring to obtain water phase, adding 65-130° white oil 7# or 15# into oil-phase stabilizer, stirring, cooling to 50-60°, dissolving span 80, stirring to obtain oil phase, mixing water phase with oil phase, emulsifying and sterilizing. The antibacterial drug can be slowly released from the emulsion. The emulsion may be used as veterinary medicine for preventing and treating animal diseases in breeding field. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to veterinary antibacterial drug sustained release emulsion, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 12, 1976, Alvan, George E.; Holstius, Elvin A. published a patent.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Solution containing trimethoprim, sulfacetamide, and polymyxin. And the patent contained the following:

Ophthalmic solutions for the treatment of microbial (especially bacterial) infections containing sulfacetamide (I) [144-80-9], a trimethoprim salt, and polymyxin salt were reported. E.g., an ophthalmic solution contains I 0.50, trimethoprim hemisulfate [56585-33-2] 0.123 g, polymyxin B sulfate [1405-20-5], 1,200,000 units, thimerosal 0.001, NaCl 0.83 g, and water for injection to 100.00 ml. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to trimethoprim sulfacetamide polymyxin ophthalmic solution, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 10, 2015, Wang, Yuwan; Dai, Xiaoxi; Pan, Zhende; Ren, Yanan; Li, Lei; Li, Ying; Weng, Zhifei; Shen, Li published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Preparation method of emulsifiable oleaginous injection containing hydrophilic medicine. And the patent contained the following:

The title emulsifiable oleaginous injection containing hydrophilic medicine is composed of hydrophilic medicine (such as valnemulin hydrochloride, tiamulin fumarate, etc.) 80-200g, poloxamer 188 20-60g, soybean phospholipids 1-5g and injection soybean oil or soybean oil/ethyl oleate to 1L. The preparation method of the emulsifiable oleaginous injection includes sterilizing injection soybean oil by heating, cooling, adding other materials and sand milling. Emulsification of emulsifiable oleaginous injection containing hydrophilic medicine occurs, when the emulsifiable oleaginous injection contacts to water, forming a emulsion or emulsion/oil system, thus reducing the release rate of drug. The emulsifiable oleaginous injection has large drug load, good biocompatibility, good stability and easy preparation method. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to hydrophilic medicine emulsifiable oleaginous injection, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 17, 2010, Xu, Kefu published a patent.Application of 23256-42-0 The title of the patent was Compounded amoxicillin soluble powder for treating duck serositis and preparation method thereof. And the patent contained the following:

The compounded amoxicillin soluble powder is prepared from (by weight%) amoxicillin 2-20, sulfamonomethoxine sodium 2-20, trimethoprim lactate 0.4-4, diclofenac sodium 2-10, anhydrous sodium carbonate 1-8, and anhydrous glucose as balance. The preparation method comprises grinding each material, and then mixing for 1 h. By cooperative effect between amoxicillin and sulfamonomethoxine sodium, the drug resistance of Riemerella anatipestifer is greatly reduced, the pathogen-resisting ability is increased, and secondary infection can be also inhibited. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application of 23256-42-0

The Article related to amoxicillin soluble powder duck serositis veterinary, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia