Category: 2380-63-4

Reference of 2380-63-4, Adding some certain compound to certain chemical reactions, such as: 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,molecular formula is C5H5N5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2380-63-4.

NIS (250 g, 1.11 mol, 1.5 eq.) was added to a solution of 1H-pyrazolo[3,4-d]pyrimidin-4-amine (100 g, 0.74 mol, 1.0 eq.) in DMF (800 mL). The reaction was stirred at 80?85 C. for 16 hours under nitrogen atmosphere. The reaction mixture was filtered, and the filter cake was washed with ethanol (1000 mL*3) to give the title compound (184 g, yield: 95%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang DTRM Biopharma Co. Ltd.; He, Wei; (167 pag.)US2016/200730; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2380-63-4, blongs to pyrimidines compound. COA of Formula: C5H5N5

Synthesis of tert-butyl 3-(4-amino-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidine-1-carboxylate: To a solution of lH-pyrazolo[3,4-J]pyrimidin-4-amine (675 mg, 5 mmol) in DMF (12 mL) was added NaH (60%wt in mineral oil, 240 mg, 6.0 mmol, 1.2 eq) and the mixture was stirred at rt for 0.5 h. The tert-butyl 3-((methylsulfonyl)oxy)piperidine-l-carboxylate (1.67 g, 6 mmol, 1.2 eq) was added and the mixture was heated to 100 C for 16 h. The solution was cooled to rt and the reaction was quenched with brine (50 mL) and extracted with EtOAc (80 mL x 4). The organic layers were dried over Na2S04i concentrated in vacuo to afford a residue which was purified by column chromatography (silica gel, pure EtOAc) to give the title product (700 n yield: 50%) as a light yellow solid. lH NMR (400 MHz, DMSO-d6) delta: 9.24 (br s, IH), 8.72 (br IH), 8.41 (s, IH), 8.33 (s, IH), 4.67-4.62 (m, IH), 4.05-3.58 (m, 3H), 3.40-3.33 (m, IH), 2.9 2.95 (m 1 H), 2.16-2.04 (m, IH), 1.61-1.24 (m, 11H). ESI-MS (M+H+): 319.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2380-63-4, its application will become more common.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art; WO2012/58645; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2380-63-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below.

500 mg 1H-pyrazole [3,4-d]pyrimidine-4-amine and 1.25 g of N-iodosuccinimide were dissolved in 5 ml of N,N-dimethylformamide, under argon, the mixture was heated to 80 C for 18 hours, and after cooled to room temperature, it was poured into 20 ml of saturated aqueous solution of sodium thiosulfate and then beated and filtered. The cake was dried to give 1.2 g of brown solid. 1H NMR (300 MHz, DMSO-d6) delta 13.81 (s, 1H), 8.13 (s, 1H), 8.17 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; DUAN, Wenhu; GENG, Meiyu; WANG, Yuming; AI, Jing; FAN, Jun; DAI, Yang; DING, Jian; (133 pag.)EP3486244; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, molecular weight is 135.1267, as common compound, the synthetic route is as follows.Computed Properties of C5H5N5

1H-pyrazolo [3,4-d] pyrimidin-4-amine (18.0 g, 130.54 mmol) was dissolved in DMF (150 mL),Then, N-iodosuccinimide (45g, 195.81mmol, Aldrich) was slowly added to the reaction solution, and the reaction was stirred at 80 C for 12 hours.Stop heating, cool, add water (200mL) to the reaction solution, suction filter,Washed with water (80 mL), washed with ethanol (60 mL), and dried to obtain 25.8 g of gray solid, yield: 75.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Yang Tiping; Zhou Youbo; Zhang Yingjun; Zheng Changchun; Luo Ming; Li Shixi; Peng Dahua; Wu Shuang; Xiong Jinfeng; (203 pag.)CN107344940; (2020); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2380-63-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 1H-pyrazolo[3,4-djpyrimidin-4-amine (Formula II, 20 g), Niodosuccinimide (41.6 g) and dimethylformamide (300 mL) was stirred at 75C to 80C for 16 hours. Water (1 L) was added to the reaction mixture, and then the mixture wasstirred at 15C for 4 hours. The solid obtained was filtered, then washed with water (100mL), and then washed with cold ethanol (60 mL). The resulting solid was dried at 45C under vacuum for 16 hours to obtain the title compound.Yield: 26.8 g

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; SHARMA, Kapil; THANKI, Bhavin Prabhudas; KHANNA, Mahavir, Singh; PRASAD, Mohan; (52 pag.)WO2016/79693; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine

A mixture of lH-pyrazolo[3,4-<^pyrimidin-4-ylamine (11.75 g, 0.09 mol) (Step A) and N-iodosuccinimide (25.45 g, 0.11 mol) in dimethylformamide (300 ml) was stirred at 50 C for 24 hr. A second batch of N-iodosuccinimide (3.92 g, 0.02 mol) was added and the solution stirred for additional 24 hr. Upon standing at room temperature, a precipitate was formed which was separated by filtration and washed with dimethylformamide and ethanol to afford 10.05 g of 3-iodo-lH-pyrazolo[3,4-(f|pyrimidin-4-ylamine. The filtrate was concentrated in vacuo to about one half of the original volume and 500 ml of water was added. The precipitated product was separated by filtration and washed with ethanol to afford a second batch of the product (10.53 g, combined yield 20.58 g, 0.08 mol); LC/MS, API-ES, Pos, (M+H)+, 262.1. With the rapid development of chemical substances, we look forward to future research findings about 2380-63-4. Reference:
Patent; FOLDRX PHARMACEUTICALS, INC.; WO2009/62118; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine

To a stirred suspension of lH-pyrazolo-[3,4-(i]pyrimidin-4-ylamine (8-1 ; 50 g) in DMF (500 mL) N-bromosuccinimide (66 g) was added and the reaction mass was heated for 5 h at 70 C. The solvent was removed under reduced pressure. Water was added to the residue and stirred for 30 minutes. The reaction mass was filtered and the solid and washed with diethyl ether. The product was dried under reduced pressure overnight to obtain the title compound as a brown solid.

With the rapid development of chemical substances, we look forward to future research findings about 2380-63-4.

Reference:
Patent; SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED; KADIYALA, V.S.N. Murty; RAUT, Virendra Narendra; SAVANT, Pratit; SHETH, Chetana Kaushal; CHAUDHARI, Umesh Vishnu; RATHOD, Rajendrasinh Jashvantsinh; BHATT, Tushar Bhupendrabhai; CHITTURI, Trinadha Rao; (50 pag.)WO2017/134685; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H5N5, blongs to pyrimidines compound. Computed Properties of C5H5N5

Step 2A mixture of lH-pyrazolo[3,4-d]pyrimidm-4-amine (150 g, 1.1 1 mo., 1.00 equiv) and N-iodo-succinimide (375 g, 1.67 mol, 1.58 equiv) in N,N-dimethylformamide (2.5 L) was stirred at 80C for 5 h. The reaction mixture was cooled to room temperature and then diluted with 10 L of water. The solid was collected by filtration, washed with 2 1 L of saturated aqueous sodium sulfite and dried under vacuum to give 50 g (52%) of 3-iodo-lH- pyrazolo[3,4-d]pyrimidin-4-amine as a yellow solid.

The synthetic route of 2380-63-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; WO2012/158795; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H5N5, blongs to pyrimidines compound. Computed Properties of C5H5N5

1H-Pyrazolo[3,4-d]pyrimidin-4-amine (4, 0.10 g, 0.74 mmol) and N-iodosuccinimide (0.25 g, 1.1 mmol) in DMF (2 ml) were heated in a microwave at 90 C for 10 min. The resulting precipitate was filtered and washed with water to afford 5 as a brown solid in 92% yield (0.17 g, 0.65 mmol). 1H NMR (200 MHz, DMSO-d6): delta 13.82 (s, 1H), 8.18 (s, 1 H), 7.10 (b, 2 H); 13C NMR (50 MHz, DMSO-d6): delta 157.6, 156.0, 155.0, 102.5, 89.8; HRMS (CI) calcd for C5H5IN5 (M) 261.9511, found 261.9510.

The synthetic route of 2380-63-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Todorovic, Nick; Awuah, Emelia; Shakya, Tushar; Wright, Gerard D.; Capretta, Alfredo; Tetrahedron Letters; vol. 52; 44; (2011); p. 5761 – 5763;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2380-63-4

1H-[3,4-d]pyrazolopyrimidin-4-amine(5.3g, 39mmol) andN-Iodosuccinimide (13.3 g, 59 mmol) was suspended in N,N-dimethylformamide,The reaction was heated to 80C under a nitrogen atmosphere for 12 hours.After the reaction is completed, it is cooled to room temperature, water is added, and a large amount of solids are precipitated and filtered with a Buchner funnel.Solids in turn with saturated sodium thiosulfate solution,Water and hot ethanol are washed twice each.The oil pump was drained to give 7.8 g of the target compound in a yield of 77%.

The synthetic route of 2380-63-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Chen Deheng; Yan Ziqin; Guo Dexiang; (85 pag.)CN107759602; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia