Category: 2380-63-4

A common compound: 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,molecular formula is C5H5N5, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 2380-63-4

Compound C (2.367 g, 17.5 mmol) and N-iodosuccinimide (4.810 g, 21.4 mmol) were added to dimethylformamide (60 mL) and stirred at 50C for 24 hours. Another batch of N-iodosuccinimide (0.871 g, 3.8 mmol) was added to the reaction mixture and was allowed to stir for an additional 24 hours. The reaction mixture was cooled to room temperature and water (100 mL) was added, forming a precipitate that was collected by filtration to yield D (4.1 g, 89%). lR NMR (DMSO- d6, 300 MHz) delta 8.18 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 2380-63-4.

Reference:
Patent; UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.; WO2011/94628; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2380-63-4, Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2380-63-4, blongs to pyrimidines compound.

IH-pyrazolo[3 4-dJpynmidn4arnine (1 5g 1111 mmol) was suspended in 15 nil of DMF and Nodosuccnmde (1 2 eq 3 0 g 13 34 mmol) added The mixture was heated at 180 0C in the microwave for an hour. EtOH (80 m) was added to the reacUonand a precipitate began to fo rn, hich was aided by sonicaton The preuipitate wasfiltered and Washed with EtOH (x3, 20 ml) and aUowed to dry in an oven at 40 Coveimghtto give a sand cooured soid (2115 g, 8105 mmol 730%) ?H NMR (500MHz, DMS06 13.80 (s, IN), 8.i(s, 1H) 7,796:.44 (m 2H);13C NMR (126 MHz,DM80) 6 157 60 (C) 156 08 CH) 155 04 (C), 102 50 (C), 89 82 (C) MS (ES +ve)[M+H)?: 283.9 (+Na), (ES -ye) [M-Hf: 259.9. 287.8 (+Na).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2380-63-4, its application will become more common.

Reference:
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH; UNCITI-BROCETA, Asier; FRASER, Craig; O. CARRAGHER, Neil; (146 pag.)WO2016/185160; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2380-63-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Example 1 :Step 1 :To the solution of 3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-amine (5.4 g, 40.0 mmol) in DMF (100 mL) was added NIS (10.8 g, 48.0 mmol). The resulting mixture was then heated to 70C and stirred for 16 h. Poured into ice water, the solid was collected by filtration, and washed with saturated aqueous Na2C03 solution and water. After drying, the desired product was obtained as yellow solid (9.3 g, 77%).

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Reference:
Patent; FUJIAN HAIXI PHARMACEUTICALS CO., LTD; KANG, Xinshan; WANG, Ruyong; ZHU, Xizhen; WO2015/18333; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia