Category: 2434-53-9

Reference of 2434-53-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H7N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-Amino-1-methylpyrimidine-2,4-dione (10.0 g, 70.1 mmol) was dissolved in water (100 mL). Hydrochloric acid (7 mL, 84.0 mmol, 12 N) was added dropwise at 0C while stirring. Then sodium nitrite (5.80 g, 84.2 mmol) was dissolved in water (50 mL) and added dropwise to the reaction solution to give a purple precipitate. The reaction was stirred at 25C for 2 hours, filtered and washed with cold water to give a purple solid. The solid was dissolved in water (100 mL) and sodium hydrosulphite (18.7 g, 118 mmol) was added in batches while stirring, heated to 60C and stirred for 0.5 h, cooled to 25C and stirred for 16 h, filtered, washed with cold water (50 mL), ethanol (50 mL), acetone (50 mL) respectively, and dried to give 5,6-diamino-1-methylpyrimidine-2,4-dione (8.60 g, as a pale yellow solid) with a yield of 93%. 1H NMR (400 MHz, DMSO-d6) delta 10.49(br, 1H), 6.15(br, 2H), 3.25(s, 3H), 2.95(br, 2H). MS-ESI calcd. [M + H]+ 157, found 157.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2434-53-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

General procedure: 7 (2.0 mmol, 0.38 g) and the corresponding amine (2.0 mmol) were placed in pressure tube under the flow of dry argon and dissolved in dry DMF (10 mL) containing 1 mL of TMSCl. The mixture was heated at 100 C during 2-12 h (controlled by TLC). Then this solution was evaporated under reduced pressure, treated with water, filtrated and dried on the air and recrystallized from an appropriate solvent, or was subjected to a column chromatography over silica gel.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Gevorgyan, Ashot; Mkrtchyan, Satenik; Arakelyan, Knar; Ostrovskyi, Dmytro; Abbasi, Muhammad S.A.; Supe, Linda; Hakobyan, Ani; Villinger, Alexander; Volochnyuk, Dmitriy M.; Tolmachev, Andrei; Tetrahedron; vol. 69; 3; (2013); p. 1217 – 1228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2434-53-9 , The common heterocyclic compound, 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Appropriate indole of 1.0 equiv, 1.1 equiv of the corresponding aminoheterocycle, and 4 equiv of TMSCl in 15 mL of anhydrous DMF was heated at 100 C under dry argon atmosphere in a pressure tube. After 6 h the solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography.

The synthetic route of 2434-53-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Knepper, Ingo; Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Domke, Lutz; Mkrtchyan, Satenik; Zahid, Muhammad; Villinger, Alexander; Langer, Peter; Tetrahedron; vol. 67; 29; (2011); p. 5293 – 5303;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 2434-53-9

General procedure: A mixture of isatin 1 (1 mmol), 1,3-indandion 2 (1 mmol), aminouracil 3 (1 mmol) andSBA-oxime-Zn (0.1 g) was heated in refluxing water(5 mL) for appropriate time (Table 1). The reactionwas monitored by TLC (n-hexane-ethyl acetate 1:1),and after completion of the reaction, the reactionmixture was filtered for separation of solid productand catalyst from water. The remaining solid waswashed with ethanol (2×10 mL) for separation ofthe product from the catalyst. Finally, the productwas purified by recrystallization in hot EtOH. The desired pure products were characterized bycomparison of their melting point data with literature.All the products are known compoundsand their melting points are compared with reportedvalues [14]. Some selected samples were alsocharacterized by IR and NMR spectroscopic data.

With the rapid development of chemical substances, we look forward to future research findings about 2434-53-9.

Reference:
Article; Ghorbani, Sayed Hosein; Hashemi, Mohammad Mahmoodi; Oriental Journal of Chemistry; vol. 31; (2015); p. 181 – 188;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione

Mixture of 6-amino-1-methyl-pyrimidine -2,4 (1H, 3H) – dione(5.46g, 40.0mmol) and bromo succinimide (7.56g, 42.0mmol) in acetonitrile (100 mL) solution was heated to reflux under nitrogen protection for 1.5 hours. The reaction was cooled to room temperature, filtered, (20 mL) and washed to remove the solvent, the resulting solid was washed with water, and dried to give 6-amino-5-bromo-1-methyl-pyrimidine -2,4 (1H, 3H)-dione (8.6g, white solid), yield: 98%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Sichuan Gooddoctor Pharmaceutical Group Co., Ltd.; Wu, Lingyun; Zhang, Peng; Zhang, Li; Li, Jian; Chen, Shuhui; Geng, Funeng; Chen, Yongmei; Liu, Bin; Ma, Xiuying; (109 pag.)CN105566324; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2434-53-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

General procedure: A solution of 6-aminouracils 1 (1.0mmol), alpha-azidochalcones 2 (1.0mmol), and NEt3 (0.5mmol) in DMF (4mL) was heated at 50C for 30min. After completion of the reaction which was monitored by TLC, the mixture was cooled down to room temperature. Then, water (10mL) was added to the mixture and extracted three times with EtOAc (3¡Á15mL). The combined organic extracts were washed with brine, dried over Na2SO4 and then concentrated. The precipitate was filtered and washed with Et2O to afford pure product 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Adib, Mehdi; Peytam, Fariba; Rahmanian-Jazi, Mahmoud; Mahernia, Shabnam; Bijanzadeh, Hamid Reza; Jahani, Mehdi; Mohammadi-Khanaposhtani, Maryam; Imanparast, Somaye; Faramarzi, Mohammad Ali; Mahdavi, Mohammad; Larijani, Bagher; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 353 – 363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below., Safety of 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione

General procedure: A solution of 6-aminouracils 1 (1.0mmol), alpha-azidochalcones 2 (1.0mmol), and NEt3 (0.5mmol) in DMF (4mL) was heated at 50C for 30min. After completion of the reaction which was monitored by TLC, the mixture was cooled down to room temperature. Then, water (10mL) was added to the mixture and extracted three times with EtOAc (3¡Á15mL). The combined organic extracts were washed with brine, dried over Na2SO4 and then concentrated. The precipitate was filtered and washed with Et2O to afford pure product 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Article; Adib, Mehdi; Peytam, Fariba; Rahmanian-Jazi, Mahmoud; Mahernia, Shabnam; Bijanzadeh, Hamid Reza; Jahani, Mehdi; Mohammadi-Khanaposhtani, Maryam; Imanparast, Somaye; Faramarzi, Mohammad Ali; Mahdavi, Mohammad; Larijani, Bagher; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 353 – 363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, the common compound, a new synthetic route is introduced below. SDS of cas: 2434-53-9

General procedure: A mixture of isatin (0.147 g, 1 mmol), acetophenone (0.09 mL, 1.5 mmol), and piperidine (two drops, 0.1 mmol) in ethanol (95.5%, 1 mL) was heated at 80 C for about 5 min. To the solid obtained at this stage was added 6-amino-1,3-dimethyluracil (0.155 g, 1 mmol), p-toluenesulfonic acid monohydrate (0.076 g, 0.04 mmol), and EtOH (95.5%, 2 mL). The mixture was stirred and heated gently at 80 C. After completion of the reaction (115 min), as monitored by TLC using 5:1 ratio of ethyl acetate/n-hexane, the reaction mixture was cooled to room temperature and then filtered. The separated solids were washed twice with 10 mL of water and 3 mL of hot ethanol (95.5%) to obtain the pure product 4a.

The synthetic route of 2434-53-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rad-Moghadam, Kurosh; Azimi, Seyyedeh Cobra; Tetrahedron; vol. 68; 47; (2012); p. 9706 – 9712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia