Category: 2434-56-2

Adding a certain compound to certain chemical reactions, such as: 2434-56-2, 4,6-Diaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2434-56-2, blongs to pyrimidines compound. Computed Properties of C4H6N4

To a stirred suspension of pyrimidine-4,6- diamine (500 mg, 4.55 mmol) in dioxane (20 mL) was added acetic anhydride (465 mg, 4.55 mmol) and the resulting mixture was heated under reflux for 15 hours. The reaction was cooled to room temperature and the resulting preceipitate was collected by filtration. The filtercake was dissolved in IN HC1 and the pH of the aqueous phase adjusted to 7 by the addition of IN NaOH. The resulting white precipitate was collected by filtration and dried to afford the desired product as a white solid (420 mg, 61% yield). LCMS (ESI) m/z: 152.0 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2434-56-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2434-56-2, Adding some certain compound to certain chemical reactions, such as: 2434-56-2, name is 4,6-Diaminopyrimidine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2434-56-2.

Compound 2~(5-chloro-2,4-dimethoxypheny])imidazo[l ,2-c]pyrimidin-7-amme 195 was prepared in the same manner as 2-(5-chloro-2,4-dimethox phenyl)-7-(pyrrolidin-l – yl)-imidazo[l ,2-o]pyridine 5a. Solid was basified with aqueous ammonia, washed with water, collected by filtration and dried. The product was obtained as a white solid (52 mg, 18% yield). 1H NMR (300 MHz, DMSO-d6): delta 8.96 (s, III), 8.14 (s, 1H), 7,99 (s, 1 H), 6.87 (s, 1H), 6.15 (tn, 2H), 4.01 (s, 3H), 3.94 (s, 3H); HPLC (Method 3) 95.12% (AUC), = 16.24 niin; ESI MS m/z 305 [M+H|+. A solution of 2-bromo-1-(5-chloro-2,4-dimethoxyphenyl)ethanone 3 (70 mg, 0.24 mmol) and 4-(pyrrolidin-1-yl)pyridin-2-amine 4a (39 mg, 0.24 mmol) in acetone (3 mL) was heated at 75 C for 16 h. The reaction mixture was cooled to room temperature; the white precipitate was collected by filtration, washed with acetone, and dried under reduced pressure to afford 2-(5-chloro-2,4-dimethoxyphenyl)-7-(pyrrolidin-1-yl)imidazo[1 ,2-a]pyridine hydrobromide 5a (45 mg, 43%) as a pink solid. 1H NMR (300 MHz, DMSO-d6) . delta 13.03 (s, 1H), 8.50 (d, J = 7.6 Hz, 1H). 8.20 (s, 1H), 7.89 (s, 1H), 6.97 (s, 1H), 6.95 (dd, J=2.2, 7.6 Hz, 1H), 6.30 (d, J= 2.0 Hz, 1H), 4.05 (s, 3H), 3.99 (s, 3H). 3.48-3.38 (m, 4H), 2.08- 1.98 (m, 4H); HPLC ( Method 4) 98.7% (AUG), tR = 19.02 min. APCI MS m/z 358 [M + H]+ .

According to the analysis of related databases, 2434-56-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2434-56-2, Adding some certain compound to certain chemical reactions, such as: 2434-56-2, name is 4,6-Diaminopyrimidine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2434-56-2.

The hydrochloric acid reaction solution was diluted to 1.5 mol / L,Cooled to -10 C,Add 82g in batchesSodium nitrite,After stirring for 1.5 h, sodium carbonate was added and the reaction solution was neutralized to pH neutral,Filtered to give a damp 4,6-diamino-5-nitrosylpyrimidine cake.The yield was 85%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2434-56-2, 4,6-Diaminopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Li, Yongshu; Yan, Yiyi; Chen, Liqi; Mao, Liping; Wang, Yunlong; (17 pag.)CN103709164; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2434-56-2, name is 4,6-Diaminopyrimidine, the common compound, a new synthetic route is introduced below. name: 4,6-Diaminopyrimidine

Compound 4,6-diaminopyrimidine 21a (70.0 mg, 0.6 mmol), 4-chloro-2-fluoropyridine (65.0 mg, 0.5 mmol) andN,N-Dimethylacetamide (5.0 mL) was added, and cesium carbonate (327.0 mg, 1 mmol) was added at room temperature, and stirred at 110 C for 3 hours.The mixture was quenched with 20 mL of water and the organic phase was separated. The aqueous phase was extracted with dichloromethane (15 mL¡Á2)Wash with saline (50 mL ¡Á 2). The organic phase is dried over anhydrous sodium sulfate, and the desiccant is removed by filtration, and the residue is evaporated to dryness.Purification by preparative silica gel plate (dichloromethane/methanol = 10:1) gave the desired product 4-(4-chloropyridin-2-yl)amino-6-aminoPyrimidine 21b (18.0 mg, 0.08 mmol, yellow solid). Yield: 16%.

The synthetic route of 2434-56-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2434-56-2, 4,6-Diaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2434-56-2, blongs to pyrimidines compound. Product Details of 2434-56-2

To a suspension of pyrimidine-4, 6-diamine (342.0 mg, 3.10 mmol) and NaHCCb (286.0 mg, 3.40 mmol) in EtOH (20 mL) was added a solution of 2-chloropropanal (0.57 M, 57 mmol) in a mixed solvent of chloroform and hexane (1/2 (v/v), 100 mL). The reaction mixture was stirred in a sealed tube at 85 C overnight, then cooled down to rt and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/20) to give the title compound as brown oil (80.0 mg, yield 17.4%).MS (ESI, pos. ion) m/z: 149.2 [M+H]+;1H NMR (400MHz, DMSO-^) d (ppm): 8.84 (s, 1H), 7.09 (s, 1H), 6.46 (s, 2H), 6.26 (s, 1H), 2.40 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2434-56-2, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia