Category: 25193-95-7

Related Products of 25193-95-7, Adding some certain compound to certain chemical reactions, such as: 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine,molecular formula is C5H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25193-95-7.

[0219] Step 4. 5-(Chloromethyl)pyrimidine. To a solution of pyrimidin-5-ylmethanol (1. lg, 10 mmol, 1.00 equiv) in dichloromethane (30 mL) was added thionyl chloride (2 mL)dropwise with stirring. The resulting solution was stirred at rt for 2 h then concentrated in vacuum to give 1.1 g of crude 5-(chloromethyl)pyrimidine as a yellow oil. TLC: ethyl acetate/petroleum ether (1:1), Rf = 0.4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang; WO2013/130935; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 25193-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into 2 g of N,N-dimethylformamide were dissolved 219 mg of 5-chloro-3-benzylthio-1,2,4-thiadiazole and 200 mg of 5-pyrimidylmethyl alcohol, 44 mg of sodium hydride (60% in oil) was added thereto under ice-cooling, and the reaction mixture was stirred for 30 minutes. After stirring for 5 hours at room temperature, the reaction mixture was added to saturated sodium chloride aqueous solution, and extracted with t-butyl methyl ether. The organic layer was concentrated, and the residue obtained was subjected to silica gel column chromatography to give 130 mg of 5-(5-pyrimidylmethyloxy)-3-benzylthio-1,2,4-thiadiazole (hereinafter, referred to as the present compound (38)). [] 1H-NMR: 9.25 (s, 1H), 8.86 (s, 2H), 7.43-7.24 (m, 5H), 5.53 (s, 2H), 4.41 (s, 2H)

According to the analysis of related databases, 25193-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP1475374; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

General procedure: Glovebox Procedure (General Procedure 1): Inside an argonfilled glovebox (O2 levels between 35.0 and 55.0 ppm, H2O levels unknown), to an oven dried 10-mL screw cap vial equipped with a Teflon-coated magnetic stir bar were added Ru-MACHO (1.2 mg, 2.00 mmol), KOH (1.7 mg, 30.0 mmol), and the appropriate phosphinic amide (0.200 mmol) in that order. Subsequently, toluene (0.7 mL) was added via micropipette, with care taken to ensure that solids on the wall were washed to the bottom of the vial. Next, the appropriate alcohol (0.240 mmol) was added either as a solid or via micropipette for liquid substrates. The reaction was sealed tightly with a non-puncturable cap and was further sealed by placing a piece of electrical tape around the cap and top of vial. Schlenk Line Procedure (General Procedure 2): To a flame-dried vial were quickly added Ru-MACHO (1.2 mg, 2.00 mmol) and KOH (1.7 mg, 30.0 mmol) (stored under Ar) (addition time 1 min), and the reaction vial was left open under a steady flow of nitrogen (applied via a needle placed at the top of the vial). Next, the appropriate phosphinic amide (0.200 mmol) was added, followed by the addition of toluene (0.7 mL) from a standard Solvent Purification System (SPS). Lastly, the appropriate alcohol (0.240 mmol) was added either as a solid or via micropipette for liquid substrates. The nitrogen line was removed, and the vial was then quickly and tightly sealed with a non-puncturable cap and further sealed by placing a piece of electrical tape around the cap and top of the vial. After the differing series of operations described above, General Procedures 1 and 2 then followed then same protocol. The reaction vessel was placed in a preheated oil bath at 110e140 C with a stirring rate of 500 rpm. As the reaction was proceeding, the vessel was periodically visually monitored. If large amounts of solid were found to have accumulated on the wall, the vial was briefly removed from the oil bath and shaken to wash the solids back to the bottom of the vial. After 16 h, the vial was removed from the oil bath and allowed to cool to room temperature. Methanol (1 mL) was added to dissolve all solids, and the solvent removed in vacuo. The solid was redissolved in methanol (1 mL), and the solution was filtered through a 40-mm syringe filter. Samples were then purified by reverse-phase HPLC or recrystallized from hot benzene. In the case of HPLC purification, the fractions were combined, frozen in liquid N2, and lyophilized to sublime the solvent.

The synthetic route of 25193-95-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jankins, Tanner C.; Qin, Zi-Yang; Engle, Keary M.; Tetrahedron; vol. 75; 24; (2019); p. 3272 – 3281;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 25193-95-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To the mixture of Compound 5 (150 mg, 0.51 mmol), DIAD (184.94 mg, 0.91 mmol) and pyrimidin-5-ylmethanol (100.71 mg, 0.91 mmol) in THF (5 mL) was added PPh3 (239.89 mg, 0.91 mmol) and the mixture was stirred at 20 C for 16 hours under N2. The mixture was concentrated, the residue was diluted with NH4C1 (20 mL) extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered, and concentrated to give a residue that was purified by Prep-HPLC (Waters Xbridge (150 mm x 25mm, 5 muiotaeta) A = H20 (10 mM NH4HCO3) and B = CH3CN); 40-70 %B over 10 minutes) to afford Compound 84 as a solid. 1H NMR (OMSO-d6 400MHz) deltaH = 9.14 (s, 1H), 8.92 (s, 2H), 7.81 – 7.74 (m, 3H), 7.51 – 7.44 (m, 4H), 5.19 (s, 2H). LCMS Rt = 1.19 min using Method A, MS ESI calcd. for C19H13F3N3O3 [M+H]+ 388.1, found 388.0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 25193-95-7, 5-(Hydroxymethyl)pyrimidine.

Reference:
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 25193-95-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Example 27 Synthesis of 3,5-dimethyl-4-hydroxy-6-(5-(5-pyrimidinylmethoxy)benzofuran-2-yl)-2H-pyran-2-one A solution of tributylphosphine in 2 N THF (0.94 ml) and a solution of TMAD (323 mg) in CH2Cl2 (3 ml) were added dropwise to a solution of 4-acetyloxy-3,5-dimethyl-6-(5-hydroxybenzofuran-2-yl)-2H-pyran-2-one (118 mg) and 5-hydroxymethylpyrimidine (202 mg) in THF (30 ml) at 0 C., and the mixture was stirred at room temperature overnight. The reaction solution was cooled on ice, a 1 N lithium hydroxide aqueous solution (5 ml) was added and the mixture was stirred at room temperature for one hour, after which the reaction solution was again cooled on ice, a 1 N hydrochloric acid aqueous solution (5 ml) and AcOEt were added, the organic layer and aqueous layer were separated, and the aqueous layer was further extracted with AcOEt. The organic layers were combined and dried with MgSO4, and then filtered and concentrated. The residue was purified by silica gel column chromatography (AcOEt/MeOH=10/1) to obtain 3,5-dimethyl-4-hydroxy-6-(5-(5-pyrimidinylmethoxy)benzofuran-2-yl)-2H-pyran-2-one. Yield: 35 mg (y. 26%) 1H NMR(delta ppm, DMSO-d6): 1.95(s, 3H), 2.29(s, 3H), 5.24(s, 2H), 7.12 to 7.14(m, 1H), 7.33 to 7.38(m, 2H), 7.61 to 7.63(m, 1H), 8.95(s, 2H), 9.18(s, 1H), 10.91(brs, 1H)

According to the analysis of related databases, 25193-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Teijin Limited; Microbial Chemistry Research Foundation; US6589984; (2003); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 25193-95-7, Adding some certain compound to certain chemical reactions, such as: 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine,molecular formula is C5H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25193-95-7.

To a solution of pyrimidin-5-yl-methanol (100 mg, 0.91 mmol, 1.0 equiv; [CASRN 25193-95-7])in anhydrous THF (6 mL) and NEt3 (97 mg, 0.13 mL, 0.95 mmol, 1.05equiv) at 0C was added slowly a solution of methanesulfonyl chloride (104 mg,0.071 mL, 0.91 mmol, 1.0 equiv) dissolved in THF (1 mL). After 30 min, sodiumiodide (136 mg, 0.91 mmol, 1.0 equiv) was added and stirring at 0C continuedfor another 30 min, then the cooling bath was removed and the reaction allowedto reach rt. After 1 h, the reaction was again cooled down to 0C and asolution of 3-(4-trifluoromethyl-phenyl)-prop-2-yn-1-ol (182 mg, 0.91 mmol, 1.0equiv; [CAS RN 173546-21-9]) in THF (3 mL) was added, followed bytreatment with potassium tert-butoxide(239 mg, 2.09 mmol, 2.3 equiv). After 1 h, the reaction mixture was allowed toreach rt and stirring continued for 18 h. The reaction was quenched by addition of a 10%solution of KH2PO4 (50 mL) and the crude product extracted with diethylether (3x 50 mL). The combined organic layers were dried over MgSO4,concentrated under reduced pressure and the product purified by MPLC elutingwith a gradient of heptane / ethyl acetate. The title compound was isolated aslight yellow solid (56 mg, 21%). 1H NMR (600 MHz, [D6]DMSO): d = 4.56 (s, 2H), 4.70 (s, 2H), 7.66 – 7.72 (m, 2H), 7.74 – 7.78 (m, 2H),8.84 (s, 2H), 9.15 (s, 1H). 13C NMR (150 MHz, [D6]DMSO): d = 58.6, 66.6, 84.9, 88.5, 123.9 (q, JCF = 274.9 Hz), 125.6 (q, JCF = 3.8 Hz), 126.0, 128.8 (q, JCF = 32.0 Hz), 131.3, 132.2, 156.5, 157.9.19F NMR (375 MHz, [D6]DMSO): d = -61.4. HRMS (ESI+): m/z [M]+calcd for C15H11F3N2O: 292.0824,found: 292.0827.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Martin, Rainer E.; Lenz, Mario; Alzieu, Thibaut; Aebi, Johannes D.; Forzy, Liliane; Tetrahedron Letters; vol. 54; 49; (2013); p. 6703 – 6707;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 25193-95-7 ,Some common heterocyclic compound, 25193-95-7, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of pyrimidin-5-ylmethanol (5.00 g, 45.4 mmol) in dichloromethane (125 mL) was added thionyl chloride (9.88 mL, 136 mmol) drop wise at 0 C, and allowed to stirred at room temperature for 2 h. The reaction mixture was analyzed by TLC (50% EtOAc/hexanes) and it showed no starting material. The reaction mixture was concentrated under reduced pressure to afford title compound (4.2 g, 69.3%) as a light brown solid. NMR (400 MHz, DMSO-c/6): delta 9.17 (s, 1 H), 8.91 (s, 2H), 4.85 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; STOLLER, Andre; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; GAGNEPAIN, Julien, Daniel, Henri; RENDINE, Stefano; (155 pag.)WO2019/86474; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia