Category: 252723-16-3

Reference of 252723-16-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

Step 3To the solution of 4-cMoro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine(10 g, 32.5. mmol, 1.0 eq) in THF (400 mL), t-BuOK (18.23 g, 163.0 mmol, 5 eq) was added and stirred at RT for 12 h. Sat, MaHC03 (50 mL) was added and extracted with EtOAc. The organic layers were separated, dried and concentrated to afford 4-chloro-6-methyl-7H- pyrrolo[2,3-d]pyrimidine.as a brown solid (2.7 g, 50 % in yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,252723-16-3, its application will become more common.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; WO2012/158795; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 252723-16-3, Adding some certain compound to certain chemical reactions, such as: 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C13H10ClN3O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 252723-16-3.

Step 3To the solution of 4-chloro-6-methyl-7-(phenylsuIfonyl)-7H-pyrrolo[‘2,3-d]pyrimidine(10 g, 32.5. mmol, 1.0 eq) in THF (400 mL), t-BuOK (18.23 g, 163.0 mmol, 5 eq) was added and stirred at RT for 12 h. Sat, NaHC03 (50 mL) was added and extracted with EtOAc. The organic layers were separated, dried and concentrated to afford 4-chloro-6-methyl-7H- pyrrolo[2,3-d]pyrimidine as a brown solid (2.7 g, 50 % in yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 252723-16-3, 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; WO2012/158764; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 252723-16-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C13H10ClN3O2S, molecular weight is 307.76, as common compound, the synthetic route is as follows.

Step 3. To the solution of 4-chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo [2,3-d]pyrimidine (10 g, 32.5. mmol, 1.0 eq) in THF (400 mL), t-BuOK (18.23 g, 163.0 mmol, 5 eq) was added and stirred at RT for 12 h. Sat. NaHCO3 (50 mL) was added and extracted with EtOAc. The organic layers were separated, dried and concentrated to afford 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine as a brown solid (2.7 g, 50 % in yield).

Statistics shows that 252723-16-3 is playing an increasingly important role. we look forward to future research findings about 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BABLER, Martin; GERRITSEN, Mary E.; WO2014/22569; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C13H10ClN3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C13H10ClN3O2S

The compound 1 (10.83 mmol), compound 2 (10.83 mmol), PdCl2(Dppf) (527 mg, 0 . 72 mmol) and KOAc (235 mg, 2.4 mmol) in toluene (30 ml) in the mixture is heated to 110 C maintain 6 hours. The reaction liquid evaporation and adding water (100 ml), and ethyl acetate (2 × 40 ml) extraction. Separating the organic phase, using anhydrous Na2SO4 drying, filtering and evaporation. Through column chromatography ethyl acetate/petroleum ether=1:4 – 1:1 to carry out the purification, to obtain 2 g solid, in THF: H 20 (24 ml: 6 ml) in the mixed solvent are added in the solution of NaIO4(18.6 Mmol), and stirring at room temperature 30 minutes. By adding 2 N HCl aqueous solution. Its stirring at room temperature 3 hours. The mixture of ethyl acetate dilution, salt water for washing, then separating and anhydrous Na2SO4Drying, filtering and concentrating. Through the use of MeOH/DCM=1:10 of column chromatography purification to obtain compound 4.

With the rapid development of chemical substances, we look forward to future research findings about 252723-16-3.

Reference:
Patent; Chengdu Shibeikang Bio-pharmaceutical Technology Co., Ltd.; Cen Guodong; Yang Maoting; Tan Shaojun; (8 pag.)CN108191874; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia