Category: 2565-47-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of compound 4a (1 mmol, 245 mg) and 5a (1 mmol, 156 mg) was taken in a round bottomed flask containing ethanol (5 ml). To this, catalytic amount of diisopropylethylamine (DIPEA) was added and the reaction mixture was stirred at room temperature for 1 h. The solid formed in the reaction process was filtered and purified by washing with ethanol and dried. The structure of the compound was ascertained as 6a from spectroscopic data.

With the rapid development of chemical substances, we look forward to future research findings about 2565-47-1.

Reference:
Article; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6949 – 6951;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, blongs to pyrimidines compound. Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 × 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, and friends who are interested can also refer to it.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H6N2O3, blongs to pyrimidines compound. Computed Properties of C5H6N2O3

(B) The 1-methylpyrimidine-2,4,6-trione prepared above is uniformly mixed with phosphorus oxychloride, and then controlled to react at 0 C for 0.8 h, followed by controlling the reaction at 50 C. After 1.5 h, finally purified and dried to obtain 3-methyl-6-chlorouracil

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anyang Normal University; Wang Xin; Sun Kai; Lv Yunhe; (12 pag.)CN109503551; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2565-47-1 ,Some common heterocyclic compound, 2565-47-1, molecular formula is C5H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 × 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2565-47-1, Adding some certain compound to certain chemical reactions, such as: 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione,molecular formula is C5H6N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2565-47-1.

(b) 6-Chloro-3-methylpyrimidine-2,4(l/J,3H)-dioneWater (2.7 mL) is added dropwise to a suspension of 1-methylpyrimidine- 2,4,6(lH,3H,5No.)-trione (14.2 g, 100 mol) in POCl3 (95 mL) at 0 0C. The reaction mixture is then heated at 80 C for 5 hours. The resulting brownish solution is cooled, and POCl3 is evaporated under reduced pressure. The residue is treated with MeOH, and the obtained solid is recrystallized from ethanol to give 11.5 g product (Yield: 71.6%). m.p. = 279-282 0C (dec) [Lit.2: 280-282 0C]. 1H NMR (400 MHz, DMSO-d6) (53.10 (S, 3H), 5.90 (S, IH), 12.4 (br, IH).

According to the analysis of related databases, 2565-47-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INTRA-CELLULAR THERAPIES, INC.; WO2006/133261; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2565-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione. This compound has unique chemical properties. The synthetic route is as follows.

(2) In a three-necked reaction flask with a stirrer, add 300 ml of dichlorosulfoxide and 40 g of methyltripyrimidone, and cool to 0 C; Take 7.5ml of water and slowly add it to the mixture; After the dropwise addition was completed, the temperature was raised to 78 C and stirred for 4h until the reaction was completed; The reaction solution was cooled to room temperature, and then added to 1,000 g of ice water, filtered, the filter cake was washed twice with 200 ml of water, dried, 31.6 g of 6-chloro-3-methyluracil was obtained with an LC purity of 98% and a yield of 70%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione.

Reference:
Patent; Suzhou Hande Chuanghong Biochemical Technology Co., Ltd.; Mao Zhongping; Ma Dongxu; Tan Jin; (9 pag.)CN110483416; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, the common compound, a new synthetic route is introduced below. Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: A mixture of compound 4a (1 mmol, 245 mg) and 5a (1 mmol, 156 mg) was taken in a round bottomed flask containing ethanol (5 ml). To this, catalytic amount of diisopropylethylamine (DIPEA) was added and the reaction mixture was stirred at room temperature for 1 h. The solid formed in the reaction process was filtered and purified by washing with ethanol and dried. The structure of the compound was ascertained as 6a from spectroscopic data.

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6949 – 6951;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2565-47-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, molecular weight is 142.1127, as common compound, the synthetic route is as follows.

Phosphoryl chloride (55 ml) is carefully added to barbituric acid (10 g, 78.1 mmol) at 0 C. Water (1.7 ml) is then added dropwise such that the temperature does not exceed 5 C. The mixture is boiled under reflux for 5 h and, after it has cooled down, poured onto ice. The product is extracted with ethyl acetate (3¡Á100 ml) and dried (Na2 SO4). The mixture is filtered and the solvent is distilled off in vacuo.

The chemical industry reduces the impact on the environment during synthesis 2565-47-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Aventis Pharma Deutschland GmbH; US2004/242583; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, the common compound, a new synthetic route is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 ¡Á 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, molecular weight is 142.1127, as common compound, the synthetic route is as follows.Recommanded Product: 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: 4.4.4. Method D (Na2CO3/DMF)Preparation of N-{[(4-hydroxy-3-nitrophenyl)carbamoyl]amino}-2,4,6-trioxo-1,3-diazinane-5-carboxamide (109). A mixtureof sodium bicarbonate (130 mg; 1.2 mmol), N,N-dimethylformamide(3 ml) and barbituric acid (256 mg 2.2 mmol) wassonicated for 1 h at 60 C. Into this solution the desired phenyl carbamate109bCF (603 mg; 2.2 mmol) was added. The reaction mixturewas sonicated at 100 C for 2 h followed by heating at 130 Cfor 2 additional hours. The reaction mixture was mixed with 5%hydrochloric acid (30 ml) and left to stir at room temperature for1 h. The formed precipitate was isolated via vacuum filtration,washed with water (3 30 ml), refluxed in ethanol (15 ml) for15 min, and then filtered to give the pure product (89%). 1H NMR(DMSO-d6, Agilent 400 MHz) d 11.15 (3H, br s), 10.59 (1H, s),9.42 (1H, br s), 9.30 (1H, s), 7.87 (1H, d, J = 8 Hz), 7.36 (1H, d,J = 4 Hz), and 7.08 (1H, d of d, J1 = 8 Hz, J2 = 4H) ppm. EMS (CH3-OH) m/z 365 (M1); M2 (366) m/z 366, 185 and 186.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, and friends who are interested can also refer to it.

Reference:
Article; Hron, Rebecca J.; Jursic, Branko S.; Neumann, Donna M.; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6183 – 6193;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia