Reference of 262353-34-4 , The common heterocyclic compound, 262353-34-4, name is 2,4-Diiodopyrimidine, molecular formula is C4H2I2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Compound 4 (1equiv per iodine atom), NEt3 (0.5mL), CuI (6mol%), and Pd(PPh3)2Cl2 (6mol%) were added to iododiazine (1mmol) in THF (5mL). The suspension was stirred at room temperature overnight under nitrogen atmosphere. The suspension was then diluted with a mixture of water and dichloromethane (1:1, 20mL) and the organic layer separated. The aqueous layer was extracted with dichloromethane (2¡Á20mL). The combined organic extracts were dried over MgSO4, filtered, and evaporated.
The synthetic route of 262353-34-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gauthier, Sebastien; Vologdin, Nikolay; Achelle, Sylvain; Barsella, Alberto; Caro, Bertrand; Robin-Le Guen, Francoise; Tetrahedron; vol. 69; 39; (2013); p. 8392 – 8399;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia