Category: 26305-13-5

Application of 26305-13-5 ,Some common heterocyclic compound, 26305-13-5, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5,6-Dimethyl-1H-pyrimidin-2,4-dione (2.5 g, 17.8 mmol) was dissolved in 12 mL of phophorus oxychloride, andthe mixture was stirred for 4 hours under reflux. The reaction solution was cooled to at room temperature and added tocold water. The formed precipitate was dried to obtain the title compound (3.08 g, 98 %).1H-NMR (DMSO-d6) delta 2.51 (3H, s), 2.30 (3H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 26305-13-5, Adding some certain compound to certain chemical reactions, such as: 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine,molecular formula is C6H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26305-13-5.

Step 1 5,6-Dimethyl-2,4-dichloropyrimidine A mixture solution of 5,6-dimethyl-2,4-dihydroxypyrimidine(72 g, 0.51 mol), phosphorous oxychloride(250 ml) and N,N-dimethylaniline(41 ml) was heated to reflux for 3 hours and cooled to room temperature. The reaction mixture was added to ice water and the resulting solid was filtered and recrystallized from dichloromethane to give 58.5 g of the titled compound. (Yield: 64.7%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yuhan Corporation; US5750531; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 26305-13-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine, molecular formula is C6H8N2O2, molecular weight is 140.14, as common compound, the synthetic route is as follows.

EXAMPLE 21 Preparation of 5-fluoro-5,6-dimethyl-6-hydroxy-5,6-dihydrouracil A suspension of 5,6-dimethyluracil (1.0g) and water (10 ml) was placed in a reaction vessel fitted with a magnetic stirrer, thermometer and gas outlet tube leading to a 10% KI trap. The suspension was heated and maintained at about 54-61C at which time F2 /N2 gas was bubbled into the suspension until fluorine was detected in the KI trap and the reaction mixture was a clear solution. The reaction mixture was allowed to cool to room temperature and 0.1 g of precipitate was collected by filtration analyzed by and identified by NMR to be 5-fluoro-5,6-dimethyl-6-hydroxy-5,6-dihydrouracil.

Statistics shows that 26305-13-5 is playing an increasingly important role. we look forward to future research findings about 2,4-Dihydroxy-5,6-dimethylpyrimidine.

Reference:
Patent; PCR, Inc.; US3954758; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 26305-13-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 5,6-dimethylpyrimidine-2,4(l f,3H)-dione (10.3 g, 0.07 mol, Step B) in phosphorus(V) oxychloride (150 mL) was added dimethylformamide (0.2 ml). The resulting mixture was refluxed overnight under argon and cooled down to ambient temperature. The resulting mixture was evaporated. Toluene (200 mL) was added to the residue. The resulting mixture was concentrated. Cold water with ice (400 mL) was added to the residue, and the mixture was extracted with chloroform (3 x 150 mL). The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel, eluting with ethyl acetate/hexane mixture (1 :2-l : 1) to yield 9.5 g (73%) of the titled compound. H NMR (400 MHz, CDC13) delta ppm 2.35 (s, 3H) 2.55 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine.

Reference:
Patent; ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail; WO2013/123401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 26305-13-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine, molecular formula is C6H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 1,3-Dibenzoyl-6-methyluracil (3). To a suspension of 6-methyluracil (5.0 g, 0.040 mol) in anhydrous MeCN (100 mL) and anhydrous pyridine (20 mL) benzoyl chloride (12.5 mL, 0.108 mol) was added in one portion and stirred at room temperature for 24 h. The reaction mixture was concentrated in vacuo at a bath temperature not exceeding 60 C, cooled and the residue partitioned between CHCl3(200 mL) and ice water (100 mL). The organic phase was separated, dried over sodium sulfate, filtered and evaporated in vacuo at a bath temperature not exceeding 60 C. The residue was crystallized from Et2O (25 mL) to give 10.0 g (76%) of compound 3 as a yellow crystalline solid with mp 80-82 .

According to the analysis of related databases, 26305-13-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ozerov, Alexander; Novikov, Mikhail; Khandazhinskaya, Anastasiya; Solyev, Pavel; Heterocycles; vol. 94; 5; (2017); p. 912 – 922;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 26305-13-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.

2,4-Dichloro-5,6-dimethylpyrimidine (RJ1-008) (WO2013/123401): A mixture of RJ1-006 (4.00 g, 28.5 mmol), phosphorus(V) oxychloride (60 mL, 0.642 mol), and dimethylformamide (0.08 mL, 1.03 mmol) was heated to reflux at 110 C for 23 hours. The reaction mixture was then cooled to ambient temperature and evaporated. Toluene (80 mL) was added to the residue and the resulting mixture was concentrated. Cold water with ice (160 mL) was added to the residue, and the mixture was extracted with chloroform (3 x 60 mL). The combined organic layers were washed with brine (2 x 150 mL), dried over sodium sulfate, filtered, and concentrated to provide RJ1-008 as a pale yellow solid (4.37 g, 87%). m.p. = 68-70 C. XH NMR (400 MHz, CDCb) delta 2.55 (s, 3H), 2.34 (s, 3H). LRMS (ESI+) m/z 177.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 26305-13-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.

A mixture of RJ1-006 (4.00 g, 28.5 mmol), phosphorus(V) oxychloride (60 mL, 0.642 mol), and dimethylformamide (0.08 mL, 1.03 mmol) was heated to reflux at 110 C for 23 hours. The reaction mixture was then cooled to ambient temperature and evaporated. Toluene (80 mL) was added to the residue and the resulting mixture was concentrated. Cold water with ice (160 mL) was added to the residue, and the mixture was extracted with chloroform (3 x 60 mL). The combined organic layers were washed with brine (2 x 150 mL), dried over sodium sulfate, filtered, and concentrated to provide RJ1- 008 as a pale yellow solid (4.37 g, 87%). m.p. = 68-70 C. NMR (400 MHz, CDCb) delta 2.55 (s, 3H), 2.34 (s, 3H). LRMS (ESI+) m/z 177.1 (MC135C135+H)+, 179.0 (MC135C137+H)+, 181.0 (MC137C137+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26305-13-5, its application will become more common.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 26305-13-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine, molecular formula is C6H8N2O2, molecular weight is 140.14, as common compound, the synthetic route is as follows.

Example 15. A/-hexyl-5,6-dimethyl-2,4-dioxo-pyrimidine-1 -carboxamide Triphosgene (0.12 g, 0.71 mmol) was added to dry pyridine (2.0 mL) at 0 C. The mixture was stirred for 10 min, then a solution of 5,6-dimethyluracil (0.10 g, 0.71 mmol) in dry pyridine (3.0 mL) was added dropwise. The pale yellow suspension formed was stirred at room temperature for 5 hrs, then cooled to 0 C before adding hexylamine (0.10 mL, 0.71 mmol). The reaction mixture was stirred at room temperature for 18 hrs. Water (30 mL) was added and the product extracted with EtOAc (3 x 30 mL). The combined organic layer was dried over Na2S04 and the solvent removed under reduced pressure. The crude was purified by column chromatography using a Teledyne ISCO apparatus (cyclohexane:EtOAc 90:10) to afford the title compound (0.02 g, 6%) as white powder. 1 H NMR (400 MHz, CDCIs): delta 0.90 (t, J = 6.6 Hz, 3H), 1 .25-1 .38 (m, 6H), 1 .53-1 .67 (m, 2H), 1 .83 (br s, 3H), 2.19 (br s, 3H), 3.30 (dt, J = 5.6, 7.0 Hz, 2H), 7.42-7.65 (m, 1 H), 9.68 (br s, 1 H). 13C NMR (101 MHz, CDCI3): delta 9.00, 13.34, 15.77, 22.35, 26.12, 28.91 , 31 .30, 40.70, 104.68, 146.24, 149.35, 162.15, 164.20. MS (ESI) m/z: 266 [M-H]”.

Statistics shows that 26305-13-5 is playing an increasingly important role. we look forward to future research findings about 2,4-Dihydroxy-5,6-dimethylpyrimidine.

Reference:
Patent; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNIVERSITA’ DEGLI STUDI DI PARMA; PIOMELLI, Daniele; REALINI, Natalia; MOR, Marco; PAGLIUCA, Chiara; PIZZIRANI, Daniela; SCARPELLI, Rita; BANDIERA, Tiziano; WO2013/178576; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia