9/27 News The origin of a common compound about 26830-94-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5HCl3N2O

To a solution of bicyclo[1 .1 .1 ]pentan-1 -amine (1-146) (4 g, 48.2 mmol) in dry THF (300 mL) was added in portions NaH (60% in oil, 5.8 g, 145 mmol) at 0 C under a nitrogen atmosphere. After the addition was completed, the mixture was stirred at 0 C for 30 min. 2,6-dichloropyrimidine-4- carbonyl chloride (1-158) (70% of purity, 21 .8 g, 72.3 mmol) was added dropwise into the reaction mixture. Upon completion of the addition, the reaction mixture was stirred at room temperature for 2 hr. TLC (petroleum ether/EtOAc = 10:1 , Rf ~ 0.6) indicated the reaction was complete. The mixture was quenched by adding AcOH (~40 mL) dropwise at 10 C. The reaction mixture was then filtered off, and washed with EtOAc (100 mL). The filtrate was concentrated. The residue was first neutralized (until no more bubbles formed) with saturated NaHCOs, and then filtered off. The filtrate was extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with brine (2 x 200 mL), dried over Na2S04, and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether to petroleum ether/EtOAc = 300:1 , Rf ~ 0.6 in 10 : 1 petroleum ether/EtOAc) to give N- (bicyclo[1 .1 .1 ]pent-1 -yl)-2,6-dichloropyrimidine-4-carboxamide (1-124) (6.5 g, 47%) as a yellow gum, which was used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

8 Sep 2021 News Some tips on 26830-94-4

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, the common compound, a new synthetic route is introduced below. Formula: C5HCl3N2O

To a solution of 2,6-dichloropyrimidine-4-carbonyl chloride (1-158) (500 mg, 2.37 mmol), and TEA (718 mg, 7.1 1 mmol) in CH2CI2 (30 ml_) was added (2R)-2-aminopropyl benzoate hydrochloride (354 mg, 1 .98 mmol) in portions at 0 C under a nitrogen atmosphere, and the mixture was stirred at 0 ~ 10 C for 1 hr. TLC (EtOAc) showed the reaction was completed. The mixture was quenched with H20 (20 ml_) and extracted with CH2CI2 (2 x 50 ml_). The combined organic layers were washed with brine (3 x 30 ml_), dried over Na2S04 and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc = 6/1 , Rf = 0.4) to give (2R)-2-{[(2,6-dichloropyrimidin-4-yl)carbonyl]amino}propyl benzoate (1-182) (3S5 mg, 46%) as an oil, which was used without further purification.

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3 Sep 2021 News Simple exploration of 26830-94-4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference of 26830-94-4, Adding some certain compound to certain chemical reactions, such as: 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride,molecular formula is C5HCl3N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26830-94-4.

To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5 M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 min. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (Si02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes and filtered to give 9.74 g (41%) of Compound 3 as an orange crystalline solid. ]H NMR (400 MHz, DMSO-d6): delta 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H). LC/MS: m/z= 192 [M+H]+ (Calc: 191).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PURDUE PHARMA L.P.; LYNCH, Stephen, M.; WO2015/112801; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3-Sep-2021 News Extended knowledge of 26830-94-4

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Application of 26830-94-4 , The common heterocyclic compound, 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3: 6-(2,6-dichloro-pyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one 2.75 g (13.0 mmol) 2,6-dichloro-pyrimidine-4-carboxylic acid chloride, 1.94 g (13.0 mmol) 4-methyl-3H-benzoxazol-2-one and 6.93 g (52.0 mmol) aluminium trichloride were heated to 125 C. for 1.5 h with stirring. The mixture combined with ice water and the product precipitated as a solid was suction filtered, washed with water and dried i. vac. Yield: 3.70 g (88% of theoretical) ESI-MS: m/z=322 (M-H)-

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/59954; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3 Sep 2021 News Simple exploration of 26830-94-4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference of 26830-94-4, Adding some certain compound to certain chemical reactions, such as: 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride,molecular formula is C5HCl3N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26830-94-4.

To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5 M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 min. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (Si02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes and filtered to give 9.74 g (41%) of Compound 3 as an orange crystalline solid. ]H NMR (400 MHz, DMSO-d6): delta 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H). LC/MS: m/z= 192 [M+H]+ (Calc: 191).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PURDUE PHARMA L.P.; LYNCH, Stephen, M.; WO2015/112801; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3-Sep-2021 News Extended knowledge of 26830-94-4

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Application of 26830-94-4 , The common heterocyclic compound, 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3: 6-(2,6-dichloro-pyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one 2.75 g (13.0 mmol) 2,6-dichloro-pyrimidine-4-carboxylic acid chloride, 1.94 g (13.0 mmol) 4-methyl-3H-benzoxazol-2-one and 6.93 g (52.0 mmol) aluminium trichloride were heated to 125 C. for 1.5 h with stirring. The mixture combined with ice water and the product precipitated as a solid was suction filtered, washed with water and dried i. vac. Yield: 3.70 g (88% of theoretical) ESI-MS: m/z=322 (M-H)-

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/59954; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 2,6-Dichloropyrimidine-4-carbonyl chloride

Statistics shows that 26830-94-4 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloropyrimidine-4-carbonyl chloride.

Synthetic Route of 26830-94-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, molecular weight is 211.4332, as common compound, the synthetic route is as follows.

10304] To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 mi Afier stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (5i02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes and filtered to give Compound 3 as an orange crystalline solid (9.743 g). Yield 41%. ?H NMR (400MHz, DMSO-d5): oe 8.40 (brs, iH), 8.i6 (br s, iH), 8.10 (s, iH). LC/MS: mlz=192 [M+H] (Calc: 191).

Statistics shows that 26830-94-4 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; Purdue Pharma L.P.; Lynch, Stephen M.; Yao, Jiangchao; Park, Jae Hyun; Tafesse, Laykea; US2015/284383; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Introduction of a new synthetic route about 26830-94-4

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Related Products of 26830-94-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5 M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 min. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (Si02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes and filtered to give 9.74 g (41%) of Compound 3 as an orange crystalline solid. ]H NMR (400 MHz, DMSO-d6): delta 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H). LC/MS: m/z= 192 [M+H]+ (Calc: 191).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; PURDUE PHARMA L.P.; LYNCH, Stephen, M.; WO2015/112801; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Share a compound : 26830-94-4

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference of 26830-94-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 mm. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (5i02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes andfiltered to give Compound 3 as an orange crystalline solid (9.74 g). Yield 41%1H NMR (400 MHz, DMSO-d6): oe 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H); LC/MS: nz/z= 192.2 [M+Hf (Calc: 191.4).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; PURDUE PHARMA L.P.; TAFESSE, Laykea; PARK, Jae, Hyun; WO2015/123398; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 2,6-Dichloropyrimidine-4-carbonyl chloride

According to the analysis of related databases, 26830-94-4, the application of this compound in the production field has become more and more popular.

Application of 26830-94-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2,6-dichloropyrimidine-4-carbonyl chloride (26.13 g, 123.6 mmol) in Et2O (500 mL) was added a mixture of 0.5M ammonia in dioxane (250 mL, 125 mmol) and iPr2NEt (22 mL, 126 mmol) dropwise over approximately 50 minutes. After stirring overnight the reaction was concentrated in vacuo to a residue and chromatographed over silica gel with 10-50% EtOAc in hexanes. The product fractions were evaporated in vacuo, and the resulting solid residue triturated with 10 mL 10% EtOAc/hexanes and filtered to give 2,6-dichloropyrimidine-4-carboxamide as an orange crystalline solid (9.743 g, 50.74 mmol, 41 % yield). LC/MS: m/z= 192.2[ +H]+, 1H NMR (400 MHz, DMSO-d6): 8.40 (1 H, br s), 8.16 (1 H, br s), 8.10 (1 H, s).

According to the analysis of related databases, 26830-94-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PURDUE PHARMA L.P.; LOCKMAN, Jeffrey; NI, Chiyou; PARK, Jae Hyun; PARK, Minnie; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YOUNGMAN, Mark, A.; WO2014/135955; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia