Category: 26893-39-0

Related Products of 26893-39-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26893-39-0, name is 2-Amino-1,4,5,6-tetrahydropyrimidine Hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

1.1 2-Pyrimidin-4-yl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one A mixture of 1.75g (9.0 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, (prepared according to the method described in patent DE 2705582), 5.0g (30.55 mmol) 1,4,5,6-tetrahydro-2-pyrimidinamine dihydrochloride (prepared according to US Patent No. 4,262,122) and 2.49g (18.0 mmol) of potassium carbonate in 30ml of methanol were heated at reflux temperature during 18 h. The reaction mixture was cooled and the solvent removed by evaporation. The residue obtained was treated with water and the precipitate recovered by filtration to give 1.15g (56%) of product. Mp.: 268-272C.

According to the analysis of related databases, 26893-39-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-SYNTHELABO; Mitsubishi-Tokyo Pharmaceuticals, Inc.; EP1295884; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 26893-39-0, 2-Amino-1,4,5,6-tetrahydropyrimidine Hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 26893-39-0, blongs to pyrimidines compound. SDS of cas: 26893-39-0

3.1. 2-(Pyridin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one A mixture of 8.98g (46.5 mmol) of ethyl 3-(4-pyridyl)-3-oxopropionate and 8.0g (46.5 mmol) of 2-amino-3,4,5,6-tetrahydropyrimidine dihydrochloride (prepared according to J. Org. Chem. 1955, 20, 829.) and 19.3g (139.5 mmol) of potassium carbonate in 60ml of ethanol was heated at reflux temperature during 18 h. The solution cooled, was evaporated to remove solvent. The residue was treated with water and extracted with dichloromethane. The extracts were dried and evaporated to give 8.0g (75%) of product as a white powder. Mp: 219 ØC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,26893-39-0, 2-Amino-1,4,5,6-tetrahydropyrimidine Hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI-SYNTHELABO; MITSUBISHI PHARMA CORPORATION; EP1340758; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia