Category: 271-80-7

271-80-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 271-80-7, name is 1H-Pyrazolo[3,4-d]pyrimidine, molecular formula is C5H4N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

520 mg (4.331 mmol) of 1H-pyrazolo[3,4-d]pyrimidine and 1.461 g (6.496 mmol) of N-iodosuccinimide were dissolved in 10 ml of DMF and the mixture was heated at 80 C. for 3 h. After cooling, the mixture was concentrated on a rotary evaporator and the residue was stirred with dichloromethane, filtered off with suction and dried under high vacuum. 569 mg (53% of theory) of the target compound were obtained. LC-MS (Method 3): Rt=1.23 min; MS (ESIpos): m/z=247 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-80-7, 1H-Pyrazolo[3,4-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; PAULSEN, Holger; Huebsch, Walter; US2013/210824; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding some certain compound to certain chemical reactions, such as: 271-80-7, name is 1H-Pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 271-80-7. 271-80-7

Compound 8a1 (1 g, 8.33 mmol) was dispersed in 1,2-dichloroethane, and N-iodosuccinimide (2.3 g, 9.02 mmol) and TDA-1 (0.5 ml). The mixture was refluxed at 90 C. After 3 h, the solvent was evaporated and the residue was extracted with hot water. The solid residue was dissolved in ethyl acetate and purified with flash chromatography. The product was obtained as yellowish solid. (1.9 g, 92.7 %). Rf (dichloromethane/MeOH 20:1) 0.34. 1H NMR (400 MHz, DMSO-d6): delta 9.04 (s, 1 H, C6-H), 9.08 (s, 1 H, C2-H), 14.51 (s, 1 H, NH). 13C NMR (101 MHz, DMSO-d6): delta 93.80, 118.55, 153.30, 154.73, 156.52.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 271-80-7.

Reference:
Article; Zhu, Junfei; Li, Zhiwen; Wang, Qi; Liu, Yang; He, Junlin; Bioorganic and Medicinal Chemistry Letters; vol. 26; 18; (2016); p. 4462 – 4465;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia