Category: 274-95-3

New learning discoveries about 274-95-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 274-95-3, Imidazo[1,2-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 274-95-3 ,Some common heterocyclic compound, 274-95-3, molecular formula is C6H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound C-1 (4 g) and sodium acetate (4.3 g) were dissolved in methanol (40 ml) into a 100 ml three-necked round bottom flask and then cooled to -10. Bromine (5.38 g) was slowly added dropwise. 1 M aqueous sodium sulfide solution (40 ml) was added, and the mixture was concentrated under reduced pressure. The by-product was extracted with ethyl acetate and water, and the resulting material was subjected to column separation using dichloromethane and methanol to obtain 3.2 g of the title compound

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 274-95-3, Imidazo[1,2-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dae Joo Electronic Materials Co., Ltd.; Park Jeong-gyu; Jang Sun-uk; Lee Hyeon-seok; Kim Min-yeong; Jeon Yeong-min; (29 pag.)KR2017/126059; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simple exploration of 274-95-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 274-95-3, Imidazo[1,2-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

274-95-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 274-95-3, name is Imidazo[1,2-a]pyrimidine. A new synthetic method of this compound is introduced below.

General procedure: Imidazo[1,2-a]pyrimidine (0.3 mmol), 2-chlorobenzaldehyde (0.9 mmol, 3 equiv.), K2CO3 (0.9 mmol, 3 equiv.), NBu4Br (0.3 mmol, 1 equiv.), PivOH (30 molpercent), Pd(OAc)2 (5 mol percent), and Xantphos (10 mol percent) were added to a 10 mL round-bottomed flask, and then a mixed solvent of 3 mL of PhNO2 and 30 uL of H2O was added. The mixture was stirred under air at 110 ¡ãC for 24 h. After the reaction was complete, the mixture was washed with water and extracted with ethyl acetate three times. The combined organic layer was dried with anhydrous MgSO4 and filtered. The filtrate was concentrated in vacuo. The crude product was purified by flash chromatography on silica gel using dichloromethane/methanol as the eluent to give the pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 274-95-3, Imidazo[1,2-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mu, Bing; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Chang, Junbiao; Wu, Yangjie; Tetrahedron Letters; vol. 58; 52; (2017); p. 4816 – 4821;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia