Category: 2802-62-2

Application of 2802-62-2 ,Some common heterocyclic compound, 2802-62-2, molecular formula is C4H2F2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) Preparation of 4-fluoro-6-<4-fluoro-3-trifluoromethylphenoxy)pyrimidine 4,6-difluoropyrimidine (2.0 g, 0.017 mol) was placed in dimethylformamide (150 cm3) with potassium carbonate (2.5 g) and the temperature reduced to about -20 C. 4-fluoro-3-trifluoro-methylphenol (2.9 g in 25 cm3 of dimethylformamide) was then added dropwise over 2 hours. The mixture was then left to stir for 4 hours between -30 and -20 C. After this time gas chromatography showed the reaction to be incomplete, so the mixture was left in the freezer overnight to prevent it from reaching room temperature. The mixture was then left to stir for a further 5 hours at -20 C. after which time gas chromatography showed no further reaction. The mixture was then poured into water, the resultant solid filtered and recrystallized from cyclohexane. Yield 0.9 g (21%): Calculated: C 47.8 H 1.8N 10.1 Found: C 48.0 H 2.2N 10.1 These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2802-62-2, its application will become more common. Reference:
Patent; American Cyanamid Company; US5707995; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2802-62-2, name is 4,6-Difluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4,6-Difluoropyrimidine

b) Preparation of 4-Fluoro-6-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]pyrimidine A solution of m-trifluoromethylphenol (74.5 g, 0.46 mol) in tetrahydrofuran (300 mL) is added dropwise to a mixture of 4,6-difluoropyrimidine (53.8 g, 0.46 mol) and potassium carbonate (60 g, 0.43 mol) in tetrahydrofuran (700 mL). The reaction mixture is stirred at room temperature for 3 days and poured into water. The resultant aqueous mixture is washed with 2Nsodium hydroxide solution and extracted with ethyl acetate. The organic extract is dried over anhydrous magnesium sulfate and concentrated in vacuoto obtain a liquid. the liquid is vacuum distilled to give the title product as an oil (87.4 g, 74% yield).

With the rapid development of chemical substances, we look forward to future research findings about 2802-62-2.

Reference:
Patent; American Cyanamid Company; EP794177; (1997); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2802-62-2, name is 4,6-Difluoropyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4,6-Difluoropyrimidine

To a mixture of 1-[(1S,1R)-1-(4-fluoro-phenyl)-ethyl]-piperazine, Example 2(b), (0.50 g, 2.4 mmol) and 4,6-difluoropyrimidine (0.28 mL, 2.4 mmol, ABCR) in DMF (8 mL) was added cesium carbonate (2.3 g, 7.2 mmol) with stirring at 0 C. The reaction mixture was stirred at 0 C. for 20 min, diluted with H2O (20 mL) and extracted with DCM (2×40 mL). The combined organic extracts were washed with H2O (2×40 mL), dried over Na2SO4 and filtered. The filtrate was evaporated and the residue was dried in vacuo to yield the title compound. MS (ESI, pos. ion.) m/z: 305 (M+1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2802-62-2, 4,6-Difluoropyrimidine.

Reference:
Patent; Wang, Hui-Ling; Balan, Chenera; Doherty, Elizabeth M.; Falsey, James R.; Gore, Vijay Keshav; Katon, Jodie; Norman, Mark H.; US2005/176726; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2802-62-2, Adding some certain compound to certain chemical reactions, such as: 2802-62-2, name is 4,6-Difluoropyrimidine,molecular formula is C4H2F2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2802-62-2.

4-Amino-phenol (0.135 g, 1.21 [MMOL)] is added in one portion to a suspension of NaH (60% free-flowing powder moistened with oil, 58.2 mg, 1.45 mmol, 1.2 equiv) in dioxane abs. (1.4 mL), under an argon atmosphere. When hydrogen evolution subsides, a solution of 4,6- [DIFLUORO-PYRIMIDINE] (0.141 g, 1.21 [MMOL)] in dioxane (0.4 mL) is added. The resulting dark mixture is stirred for 1.5 h at rt, quenched by addition of MeOH (2 mL) and concentrated in vacuo. After addition of CH2CI2, the resulting suspension is filtered and concentrated in vacuo. The residue is purified by silica gel column chromatography [(CH2CI2/ET2O,] 90/10, then 85/15) to afford the title compound as a white solid : ES-MS: 204.0 [M+H] [+] ; single peak at [TR=] 4. 96 min (System 2); Rf = 0.30 [(CH2CI2/ET20,] 85/15).

According to the analysis of related databases, 2802-62-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/99771; (2003); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia