Category: 287714-35-6

Adding a certain compound to certain chemical reactions, such as: 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 287714-35-6, blongs to pyrimidines compound. Recommanded Product: 287714-35-6

A solution of methyl 2-chloropyrimidine-5-carboxylate (300 mg, 1.74 mmol) in DCM (4.70 mL) was added to a stirred solution of 2-(methoxymethyl)piperazine (226 mg, 1.74 mmol) and N-ethyl-N-propan-2-ylpropan-2-amine (0.752 mL, 4.35 mmol) in DCM (4.00 mL) at 25 C. under nitrogen. The resulting solution was stirred at room temperature for 6 h. The reaction mixture was concentrated and diluted with MeOH. The resulting mixture was filtered. The filtrate was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 7M NH3/MeOH and fractions were evaporated to dryness to afford methyl 2-(3-(methoxymethyl)piperazin-1-yl)pyrimidine-5-carboxylate (346 mg, 75%) as a yellow solid. This was used directly with no further purification. 1H NMR (399.9 MHz, CDCl3) delta 2.72-2.79 (2H, m), 2.84-2.90 (1H, m), 2.99-3.07 (2H, m), 3.25-3.30 (1H, m), 3.31 (3H, s), 3.38-3.42 (1H, m), 3.80 (3H, s), 4.61-4.68 (2H, m), 8.76 (2H, s). MS: m/z 267 (MH+)

The synthetic route of 287714-35-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 287714-35-6 ,Some common heterocyclic compound, 287714-35-6, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Chloropyrimidine-5-carboxylic acid methyl ester (434mg, 2.33 mmol) was added to a stirring suspension of (2R)-2-amino-3-methyl-3-{[(2E)-3,7,11,15- tetramethylhexadec-2-en-1-yljsulfanyl}butanoic acid (ig, 2.33 mmol) and N,Ndiisopropylethylamine (1.2lmL, 6.99 mmol) in dioxane (lOmL) at room temperature and heated to 60C overnight. The reaction mixture is cooled to room temperature and washed once with brine. The reaction mixture is diluted with an additional 5mL of dioxane, followed by addition of 1M lithium hydroxide (lOmL) at room temperature and stirred overnight. The reaction mixture is diluted with ethyl acetate, washed with 10% w/v citric acid solution, then brine and dried over magnesium sulfate. The ethyl acetate is filtered and concentrated on a rotary evaporator to give the crude product as a yellow oil that is purified by flash chromatography using ethyl acetate in hexanes as the eluent to give the purified carboxylic acid as an off-white solid. The carboxylic acid was dissolved in ethanol, then solid sodium ethoxide was added until the pH reached 9. The resulting ethanolic suspension was centrifuged at 2000 rpm for 2 minutes. The ethanol was decanted and the ethanol wash was repeated twice more. Acetonitrile was then substituted for ethanol and the wash was repeated three times. The resulting solid was dried on a rotary evaporator to give 165mg of a white solid in 12% yield. ?H NMR (500 MHz, Deuterium Oxide) 8.61 (s, 2H), 5.07 (s, 1H), 4.21 (s, 1H), 3.17 – 3.02 (m, 2H), 1.92 – 1.74 (m, 2H), 1.49 (d, J = 6.4 Hz, 3H), 1.44 – 0.82 (m, 26H), 0.79 – 0.64 (m, 12H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,287714-35-6, its application will become more common.

Reference:
Patent; SIGNUM BIOSCIENCES, INC.; VORONKOV, Michael; PEREZ, Edwardo; HEALY, Jason; FERNANDEZ, Jose; (139 pag.)WO2018/132759; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 287714-35-6, Adding some certain compound to certain chemical reactions, such as: 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 287714-35-6.

1.3.1 Intermediate 10 ADiisopropylethylamine (1.5 mL, 8.7 mmol) was added to a mixture of methyl 2- chloropyrimidine-5-carboxylate (0.5 g, 2.9 mmol) and (3R)-3-methoxypyrrolidine hydrochloride (0.48 g, 3.48 mmol) in acetonitrile (6 mL) and the mixture was micro waved at 140 C for 30 min. The reaction was diluted with ethyl acetate (20 mL), water (10 mL) and sodium carbonate (sat., aq., 10 mL). The phases were separated and the aqueous phase was re- extracted with ethyl acetate (2 x 20 mL) and the combined organic phases were washed with water (10 mL), brine (2 x 10 mL), dried (MgS04), filtered and concentrated. The residue was purified by silica chromatography, 0-100% ethyl acetate in petrol to give product as a light yellow solid methyl 2-[(3R)-3-methoxypyrrolidin-l-yl]pyrimidine-5-carboxylate (0.66 g, 95 % yield). NMR (400 MHz, CD3OD) delta 8.80 (s, 2H), 4.10 – 4.16 (m, 1H), 3.86 (s, 3H), 3.71 – 3.81 (m, 2H), 3.55 – 3.70 (m, 2H), 3.36 (s, 3H), 2.04 – 2.24 (m, 2H)MS (ES+) 238

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; POONI, Parminder, Kaur; MERCHANT, Kevin, John; BUFFHAM, William, John; WO2011/83314; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below., Formula: C6H5ClN2O2

A solution of methyl 2-chloropyrimidine-5-carboxylate (200 mg, 1.16 mmol) in dichloromethane (4.00 mL) was added to a stirred solution of 1-methyl-1,4-diazepane (0.144 mL, 1.16 mmol) and N-ethyl-N-propan-2-ylpropan-2-amine (0.902 mL, 5.22 mmol) in dichloromethane (4.00 mL) at 25 C. The resulting solution was stirred at ambient temperature for 18 h. The reaction mixture was evaporated to dryness and redissolved in MeOH (20 mL) and the crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH and evaporated to dryness to afford methyl 2-(4-methyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate (274 mg, 94%) as a white solid. This was used directly with no further purification. 1H NMR (399.9 MHz, DMSO-d6) delta 1.86-1.89 (2H, m), 2.26 (3H, s), 2.49-2.54 (2H, m, partially obscured by DMSO peak), 2.62-2.64 (2H, m), 3.81 (3H, s), 3.80-3.84 (2H, m), 3.89-3.91 (2H, m), 8.79 (2H, d). MS: m/z 251 (MH+)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 287714-35-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, molecular weight is 172.57, as common compound, the synthetic route is as follows.

A solution of (2S)-2-propan-2-ylpiperazine (223 mg, 1.74 mmol) in dichloromethane (4.40 mL) was added to a stirred solution of methyl 2-chloropyrimidine-5-carboxylate (300 mg, 1.74 mmol) in dichloromethane (4.30 mL) at 25 C. N-Ethyl-N-propan-2-ylpropan-2-amine (0.752 mL, 4.35 mmol) was added. The resulting solution was stirred at room temperature for 18 h under a nitrogen atmosphere. The reaction mixture was concentrated and diluted with methanol. The crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 7M NH3/MeOH and fractions were evaporated to dryness to afford the desired compound (456.1 mg, 99%) as a yellow oil. This was used directly with no further purification. 1H NMR (399.9 MHz, DMSO-d6) delta 0.94-0.96 (6H, m), 1.58-1.66 (1H, m), 2.25-2.30 (1H, m), 2.56-2.63 (1H, m), 2.68-2.74 (1H, m), 2.95-3.02 (2H, m), 3.81 (3H, s), 4.56-4.60 (1H, m), 4.64-4.68 (1H, m), 8.78 (2H, s). MS: m/z 265 (MH+)

Statistics shows that 287714-35-6 is playing an increasingly important role. we look forward to future research findings about Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 287714-35-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, molecular weight is 172.57, as common compound, the synthetic route is as follows.

Methyl 2-chloropyrimidine-5-carboxylate (0.927 g, 5.37 mmol) was added to a mixture of tert-butyl piperazine-l-carboxylate (1 g, 5.37 mmol) and DIPEA (2.34 mL, 13.4 mmol) in DCM (10 mL) in a 20 mL vial (exotherm). The reaction was then stirred at room temperature (bath temp). After 40 min, additional DCM (5 mL) was added along with an aqueous solution of 10 wt% citric acid (45 mL). The layers were separated, and the aqueous layer was extracted with DCM (10 mL). The combined organic layers were dried (Na2S04), concentrated under reduced pressure, and dried under high vacuum, giving 1.74 g (100%) of the title compound as a pale yellow-tan solid. LC/MS: m/z 323.0 (M+H)+, RT=1.00 min H NMR (400MHz, DICHLOROMETHANE-d2) delta = 8.82 (s, 2H), 3.89 (d, 7=4.5 Hz, 4H), 3.85 (s, 3H), 3.49 (t, 7=4.9 Hz, 4H), 1.47 (s, 9H)

Statistics shows that 287714-35-6 is playing an increasingly important role. we look forward to future research findings about Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; HARLING, John David; NEIPP, Christopher E.; PENDRAK, Israil; SMITH, Ian Edward David; TERRELL, Lamont Roscoe; YOUNGMAN, Mark; (120 pag.)WO2017/46036; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 287714-35-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, molecular weight is 172.57, as common compound, the synthetic route is as follows.

Methyl 2-chloropyrimidine-5-carboxylate (0.927 g, 5.37 mmol) was added to a mixture of tert-butyl piperazine-l-carboxylate (1 g, 5.37 mmol) and DIPEA (2.34 mL, 13.4 mmol) in DCM (10 mL) in a 20 mL vial (exotherm). The reaction was then stirred at room temperature (bath temp). After 40 min, additional DCM (5 mL) was added along with an aqueous solution of 10 wt% citric acid (45 mL). The layers were separated, and the aqueous layer was extracted with DCM (10 mL). The combined organic layers were dried (Na2S04), concentrated under reduced pressure, and dried under high vacuum, giving 1.74 g (100%) of the title compound as a pale yellow-tan solid. LC/MS: m/z 323.0 (M+H)+, RT=1.00 min H NMR (400MHz, DICHLOROMETHANE-d2) delta = 8.82 (s, 2H), 3.89 (d, 7=4.5 Hz, 4H), 3.85 (s, 3H), 3.49 (t, 7=4.9 Hz, 4H), 1.47 (s, 9H)

Statistics shows that 287714-35-6 is playing an increasingly important role. we look forward to future research findings about Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; HARLING, John David; NEIPP, Christopher E.; PENDRAK, Israil; SMITH, Ian Edward David; TERRELL, Lamont Roscoe; YOUNGMAN, Mark; (120 pag.)WO2017/46036; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 287714-35-6, Adding some certain compound to certain chemical reactions, such as: 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 287714-35-6.

To a stirred solution of methyl 2-chloropyrimidine-5-carboxylate (5 g, 28.97 mmol) in dry DMF (60 mL), TEA (12.09 mL, 86.92 mmol) and tert-butyl piperazine-1-carboxylate (5.93 g, 31.87 mmol) were added at 0 C. The reaction mixture was heated at 100 C overnight. Itwas concentrated to half of the volume and filtered. The resulting solid was dissolved inDCM (35 mL) and washed with water (20 mL), dried over Na2SO4 and concentratedaffording the title product. Yield: 70% (7 g, off white solid). 1H NMR (400 MHz, DMSO-d6):6 8.81 (5, 2H), 3.84 (t, J = 4.8 Hz, 4H), 8.80 (5, 3H), 3.48-3.38 (m, 4H), 1.42 (5, 9H). LCMS:(Method A) 323.3 (M+H), Rt. 4.31 mm, 99.89% (Max).

According to the analysis of related databases, 287714-35-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 287714-35-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

A solution of methyl 2-chloropyrimidine-5-carboxylate (200 mg, 1.16 mmol) in dichloromethane (4.00 mL) was added to a stirred solution of 1-ethyl-1,4-diazepane (149 mg, 1.16 mmol) and N-ethyl-N-propan-2-ylpropan-2-amine (0.902 mL, 5.22 mmol) in dichloromethane (4.00 mL) at 25 C. The resulting solution was stirred at ambient temperature for 18 h. The reaction mixture was evaporated to dryness and redissolved in MeOH (20 mL) and the crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH and evaporated to dryness to afford methyl 2-(4-ethyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate (268 mg, 87%) as a cream oil which crystallised on standing. This was used directly with no further purification. 1H NMR (399.9 MHz, DMSO-d6) delta 0.98 (3H, t), 1.81-1.87 (2H, m), 2.45-2.50 (2H, m), 2.55 (2H, m), 2.70-2.72 (2H, m), 3.81 (3H, s), 3.82 (2H, q), 3.86-3.89 (2H, m), 8.79 (2H, s). MS: m/z 265 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Methyl 2-chloropyrimidine-5-carboxylate

Step A Methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate A 20 mL microwave vial was charged with 0.500 g (2.90 mmol) of methyl-2-chloropyrimidine-5-carboxylic acid, 0.934 g (3.77 mmol) of [4-(propyloxy)-2-(trifluoromethyl)phenyl]boronic acid and 1.23 g (5.79 mmol) of K3PO4 followed by 9 mL of 8:1 dioxane/water. The mixture was deoxygenated by bubbling nitrogen through for 5 minutes, treated with 0.10 g (0.087 mmol) of Pd(Ph3P)4 and the vessel sealed. The mixture was subjected to microwave heating at 120 C. for 20 minutes. This same procedure was repeated twice. The crude mixtures from all three reactions were combined and partitioned between EtOAc and water. The phases were separated and the aqueous phase extracted with EtOAc (3*). The combined EtOAc solutions were washed with water (1*), saturated brine (1*), dried over sodium sulfate and concentrated to dryness at reduced pressure. The crude residue was purified by flash chromatography (silica gel, gradient elution from hexane to EtOAc) to afford 1.70 g (58%) of methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate as a white crystalline solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.27 (s, 2H) 7.79 (d, J=8.6 Hz, 1H) 7.22-7.40 (m, 2H) 4.06 (t, J=6.5 Hz, 2H) 3.89 (s, 3H) 1.73 (sxt, J=7.0 Hz, 2H) 0.96 (t, J=7.4 Hz, 3H). LCMS m/z 341 (M+1).

With the rapid development of chemical substances, we look forward to future research findings about 287714-35-6.

Reference:
Patent; Leivers, Martin; Miller, John; US2011/52534; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia