Category: 289042-12-2

Synthetic Route of 289042-12-2 , The common heterocyclic compound, 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4 (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[Methyl(Methylsulfonyl)Amino]-6-(Propan-2-Yl)Pyrimidin-5-Yl]-3,5-Dihydroxyhept-6-Enoic Acid-2-Methylpropan-2-Amine (1:1) Hydrochloric acid (2 N; 60 mL) was added to a solution of tert-butyl [(4R,65)-6-{(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]ethenyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate (Example 3; 50 g) in acetonitrile (500 mL) at room temperature and stirred at the same temperature for 3 hours. After completion of the reaction, aqueous solution of sodium hydroxide (10%; 90 mL) was added to the reaction mixture at room temperature and the temperature of the mixture was allowed to rise to 40 C. to 45 C. The pH of the reaction mixture was adjusted to 12 to 12.8 using aqueous solution of sodium hydroxide (10%). Acetonitrile was recovered completely under vacuum at 45 C. to 50 C. De-ionized water (250 mL) was added to the resulting residue at room temperature. Methyl tert-butyl ether (200 mL) was added to the mixture and stirred for 10 minutes. Layers were separated and methyl tert-butyl ether (200 mL) was added to the aqueous layer and stirred for 10 minutes. Layers were separated and aqueous layer was cooled to 5 C. to 10 C. and adjusted to a pH of 3.5 to 4.0 using hydrochloric acid (2N). Dichloromethane was added to the resulting mixture and stirred for 10 minutes to 15 minutes. Dichloromethane was recovered completely under vacuum at 35 C. to 40 C. Acetonitrile (500 mL) was added to the resulting residue and mixture was cooled to 0 C. to 5 C. To this cooled layer, tert-butyl amine (7 g) was slowly added for 30 minutes at 0 C. to 5 C. and stirred for 2 hours at 10 C. to 15 C. The product was filtered, washed with acetonitrile (50 mL) and dried under vacuum at 45 C. for 3 hours. Dry weight: 40 g

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; Pandya, Vishwesh Pravinchandra; Richhariya, Santosh; Divya, Prabhakar; Meeran, Hashim Nizar Poovanathil Nagoor; Tewari, Neera; US2013/150579; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

BEM (20.0 g) was dissolved in acetonitrile (140 ml) at 40 C., then cooled to 35 C. before gradual addition of hydrochloric acid (0.02M, 35 ml) at 35 C. The resulting solution was stirred at 35 C. until the reaction was complete then cooled to 25 C. Further acetonitrile (8 ml) was added before sodium hydroxide (1.0M, 38 ml) was added at 25 C. and the resulting mixture stirred at this temperature until the reaction was complete. Aqueous hydrochloric acid (0.1M) was added to adjust the pH of the solution to approximately pH10.5. Water was added so that the combined volume of water and hydrochloric acid (0.1M) (from the previous pH adjustment step) added was 100 ml. Toluene (125 ml) was then added and the mixture stirred at 40 C. for 30 minutes before it was allowed to settle for 1 hour at 40 C. The aqueous phase was then separated from the organic phase at 40 C. The aqueous phase was distilled under reduced pressure (53 mBar, 40 C.) until the volume was reduced to 135 ml. The resulting aqueous solution was filtered through a filter pad and the filter washed with water and combined with the aqueous reaction solution, such that the total volume of the resulting aqueous solution was 170 ml. This solution was heated to 40 C. before addition of a solution of calcium chloride di-hydrate (3.05 g) in water (29.5 ml) over 20 min, maintaining the reaction mixture at 38-41 C.The reaction mixture was stirred for a further 15 min at 40 C., then cooled to 20 C. and stirred at this temperature for a further 15 min. The resulting suspension was filtered, washed with water (3×53 ml) and dried to give (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt (14.7 g(at)100% strength, 85% yield).1HNMR delta: 1.21 (d+d, 6H) 1.32 (dt, 1H) 1.51 (dt, 1H) 2.00 (dd, 1H) 2.14 (dd, 1H) 3.42 (spt, 1H)* 3.45 (s, 3H) 3.54 (s, 3H) 3.77 (m, 1H) 4.21 (q, 1H) 5.53 (dd, 1H) 6.51 (dd, 1H) 7.27 (t, 2H) 7.71 (dd, 2H) *partially obscured[The 1H NMR was carried out as a 3% w/v solution in d6 DMSO (where d5 DMSO=2.51delta)].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 289042-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of compound IV (wherein X=0 and R2=tert-butyl; 100 gms) in acetonitrile (700 mL) at 35C to 40C was added 0.05M aqueous HCl solution (300 mL). Stirred the reaction mass at 35C to 40C until reaction completion and cooled to 0C to 5C. Added 1.0 M aqueous sodium hydroxide solution (300 mL), temperature was raised to 25 C to 35C and stirred until reaction completion. Cooled the reaction mass to 0C to 5C, pH was adjusted to 3.4 to 4.0 with 1M aqueous HCl solution (300 mL) and extracted with ethyl acetate. Washed the organic layer with 10% aqueous sodium chloride solution and concentrated under vacuum. Charged ethyl acetate (800 mL) to the obtained residue followed by cyclohexane- 1,2-diamine (29.5 gms) over a period of 15-30 min. The reaction mass was stirred at 25C to 35C for 60 mins, cooled to 0C to 5C and stirred for 2 hrs. The precipitated product was filtered and dried to obtain 80 gms of rosuvastatin cyclohexane- 1,2-diamine salt as white solid. HPLC Purity: >99% The XRPD is set forth in Figure 1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.

Reference:
Patent; LAURUS LABS PRIVATE LIMITED; BOLLU, Ravindra Babu; MANDADAPU, Venkata Pramod Kumar; INDUKURI, Venkata Sunil Kumar; GORANTLA, Seeta Rama Anjaneyulu; CHAVA, Satyanarayana; (48 pag.)WO2016/125086; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, the common compound, a new synthetic route is introduced below. Safety of tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

A solution of the compound of formula (39) (7.0 g, 12.1 MMOL) and CAMPHOR-1 0-SULFONIC ACID (2.4 g, 10.4 MMOL) in acetonitrile (50 ml) and water (5 ml) is stirred at room temperature for 30 minutes. It is then diluted with ether and washed successively with saturated sodium hydrogen carbonate solution and brine. The organic phase is dried (using NA2SO4). The salt mixture is filtered off and the filtrate obtained is concentrated by evaporation. The concentrated crude product is dissolved in ethyl acetate and made to crystallise by adding hexane. In that manner, 1.6 G (57 %) of the desired product (41) can be obtained in the form of colourless crystals. ‘H NMR (300 MHz, DMSO-DE) : 1.22 (d, J = 6.7 Hz, 6H); 1.32-1. 44 (m, 1H) ; 1. 38 (s, 9H); 1.49-1. 59 (m, 1H); 2.20 (dd, J = 15.0, 7.9 Hz, 1H); 2.28 (DD, J = 15.0, 5.3 Hz, 1H); 3.39-3. 47 (m, 1H) ; 3.44 (s, 3H); 3.53 (s, 3H); 3.74-3. 85 (M, 1H) ; 4.14-4. 22 (m, 1H) ; 4.64 (d, J = 5.3 Hz, 1H) ; 4.89 (d, J = 4.7 Hz, 1H) ; 5.51 (dd, J = 16.1, 5.6 Hz, 1H) ; 6.51 (dd, J = 16. 1,1. 2 Hz, 1H) ; 7.25 (dd, J = 8.8, 8.8 Hz, 2H); 7.70 (dd, J = 9.1, 5.6 Hz, 2H). 13C NMR (75 MHz, DMSO-DB) : 22.4, 28.6, 32.1, 34.0, 42.4, 44.4, 44.9, 65.9, 69.2, 80. 2, 115.7 (JCF = 21.7 Hz), 122.1, 122.4, 132.8 (JCF = 8.7 Hz), 135.1 (JCF = 3.2 Hz), 141.9, 157.4, 163.2 (JCF = 249 Hz), 163.4, 171.1, 174.9. HPLC: CHIRALCEL OD (0.46×25 cm), hexane: EtOH 95: 5,1 ml/min, TR = 19.2 min, S 98 % ee.

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CIBA SPECIALTY CHEMICALS HOLDING INC.; WO2004/103977; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C29H40FN3O6S, blongs to pyrimidines compound. HPLC of Formula: C29H40FN3O6S

The method for synthesizing the rosuvastatin calcium chiral isomer impurity of the present embodiment comprises the following steps:(1) 20g compound I was added to 500mL three reaction flask, stirred and dissolved in 220mL of acetonitrile was added dropwise 60mL 0.05M hydrochloric acid, the reaction was incubated dropwise at 35 ~ 40 C for 3 hours until the starting material disappeared (TLC: Ester: petroleum ether = 6: 1),The pH was adjusted to neutral with 5% sodium bicarbonate solution, the acetonitrile was removed by distillation under reduced pressure, extracted twice with methylene chloride (100 mL * 2), dried over anhydrous sodium sulfate, filtered,The filtrate was transferred to 500mL three reaction flask, 60g of manganese dioxide was added, the reaction was refluxed for 20 hours, the reaction was over, filtered, the filtrate was evaporated under reduced pressure and concentrated to dryness to give 17.6g light yellow oil, namely compound III, directly into the next reaction; The yield of compound III was 95.2%

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Mei Nuohua Pharmaceutical Chemical Co., Ltd.; Yu Kui; Huang Xiangliang; Jia Jiangnan; Liu Tao; Yu Shenggang; Lin Zufeng; Chen Weiren; Yao Chengzhi; (12 pag.)CN107382875; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 289042-12-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, molecular weight is 577.71, as common compound, the synthetic route is as follows.

To a solution of acetonide protected tert-butyl ester of rosuvastatin (II) (25 g) a dilute solution of TFA in water (2.5 g in 25 mL water) was added at 30-40 C. The reaction was stirred for 30 minutes to 1 hour and then water (25 mL) was added to it. The reaction mixture was again stirred for 3-4 hours at the same temperature. Then an aqueous solution of sodium hydroxide (3.46 g in 100 mL water) was added and the reaction mixture was stirred for 1 hour. The reaction mixture was further diluted with water (200 mL) and washed with toluene (2 x 250 mL) and MTBE (125 mL). MTBE (250 mL) was further added to the aqueous layer. Then sodium chloride (6.25 g) was added to the reaction mixture. An aqueous solution of sodium bisulphate (15 g in 100 mL of water) was added to the reaction mass and the pH was adjusted to 2.4. The organic layer was separated. The aqueous layer was again extracted with MTBE (200 mL) and the combined organic layer was washed with sodium chloride solution (125 mL). A solution of tert-butyl amine (7.91 g) in MTBE (250 mL) was added to the reaction mixture and stirred for 2-6 hours. The reaction mixture was cooled to 15-20 C and stirred at this temperature for 1 hour. The precipitated solid was isolated and dried. The solid was suspended in a mixture of acetonitrile (62.5 mL) and IPA (62.5 mL) and heated to a temperature of 50-55 C for 1-3 hours. The reaction mixture was then cooled to 25-35 C and stirred at this temperature for 2-6 hours. The reaction mixture was further cooled to 10-15 C and stirred for 1 hour. The precipitated solid was filtered, washed with a mixture of acetonitrile and IPA and dried to provide the title compound.Yield: 20.5 g (86 %)Purity by HPLC: 99.82 %

The chemical industry reduces the impact on the environment during synthesis 289042-12-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; DR. REDDY’S LABORATORIES LIMITED; DAHANUKAR, Vilas Hareshwar; AMBHAIKAR, Narendra Bhalchandra; VADALI, Ravi kumar; MERUVA, Suresh babu; MANIKONDA, Swapna; KAMARAJU, Raghavendra Rao; TIMMANNA, Upadhya; MOHAMMED, Aaseef; PULIPATI, Ranga Prasad; MOHAMMED, Yakub Iqbal; WO2012/172564; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

3 g of the compound prepared in Example 1 is dissolved in 30 ml of ACN at room temperature, and then 9 ml of 1N HCl is added. The reaction is completed by stirring at room temperature for 8 hours.The reaction was cooled and maintained at 0 C,Add 0.9 g 10% aqueous NaOH solution.The reaction is allowed to warm to room temperature and then stirred for 4 hours to complete the reaction. Water is added to quench the reaction and then 3 mL of 1N HCl is slowly added dropwise to bring the pH to 8.0. The aqueous layer was washed with methylene chloride to separate the aqueous layerdo. 2.7 g of CaCl2 was added thereto, followed by stirring at room temperature for about 30 minutes. The reaction solution is kept below 15 C to produce a solid and then filtered.After washing with water, suvastatin was dried under reduced pressure to obtain 2.6 g of a calcium salt of a white solid.

According to the analysis of related databases, 289042-12-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WELL ENC CO., LTD; GO, SUNG HWAN; KIM, GYUNG IR; GO, YOUNG LI; PARK, YONG MUK; JUNG, HUN HWEE; (18 pag.)KR101566536; (2015); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 289042-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 3 L four-necked flask was added 1.5 L of absolute ethanol and 128.0 g of 6 – [(1E) -2- [4- (4-fluorophenyl) -6-isopropylYl-2- [methyl (methylsulfonyl) amino] -5-pyrimidine] vinyl] -2,3-dimethyl-1,3-dioxacyclohexane-4-acetic acid tert-butyl ester(Compound III). After stirring, 450 g of dilute hydrochloric acid solution with a mass fraction of 3.6% was added dropwise, stirred at room temperature for 4 to 6 hours, and TLC was monitored until compound III disappeared. After completion of the reaction, 320 g of a sodium hydroxide solution having a mass fraction of 4% was added dropwise to the reaction system and stirring was continued for 4 to 6 hours. The reaction was continued until the first stage of the dihydroxy ester intermediate was completely disappeared (residual?0.5%). The ethanol was then concentrated under reduced pressure, and then 2 L of purified water was added to the system. After stirring, the mixture was extracted twice with methyl t-butyl ether and the aqueous phase was concentrated to no organic solvent residue. The mass fraction was then slowly added to the resulting aqueous solution For 10% of the calcium acetate solution 420g, a white solid precipitation, after the drop is completed, continue stirring 4 to 6 hours, filtration, filter cake with 2L purified water beating 1 times, dry, filter cake vacuum drying, Statin calcium A, the yield was 87.0%, content ? 99.0%, purity(HPLC) ?99.0%, single maximum impurity ? 0.5%, product ee value ? 99.9%.

According to the analysis of related databases, 289042-12-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Anhui Mei Nuohua Pharmaceutical Chemical Co., Ltd.; Shi Jianxiang; Pan Qijiao; Ding Maohua; Gong Daoxin; Zhu Guosheng; (14 pag.)CN106674281; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 289042-12-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, molecular weight is 577.71, as common compound, the synthetic route is as follows.

A mixture of BEM (5.0 g) and acetonitrile (35 ml) was stirred under an inert atmosphere at 40 C. 0.02M hydrochloric acid (9.5 ml) was added over 30 minutes to the resultant solution, maintaining the temperature at 35 C. to 42 C. The mixture was stirred at 40 C. for 3 hours then cooled to 25 C. 1.0M sodium hydroxide solution (9.5 ml) was added with stirring at 25 C. and the mixture was stirred for an additional one hour at 25 C. Sodium chloride (4.7 g) was added and the mixture was cooled to -5 C. over one hour. Sufficient of a solution of 1M hydrochloric acid (9.5 ml) and sodium chloride (2.4 g) was added at -5 C. to achieve a pH of 3.4 to 4.0 and the mixture stirred at this temperature for 5 minutes. The mixture was allowed to settle for 10 minutes at -5 C. to give two layers. The lower layer was separated and discarded. Acetonitrile (65 ml) at -5 C. was added to the remaining solution and the mixture was filtered through a filter agent. 40% methylamine solution in water (1.1 ml) was added at -5 C. and the mixture was warmed to 30 C. over 40 minutes and maintained at this temperature for 90 minutes. The mixture was then cooled to 0 C. over 40 minutes and maintained at this temperature for 90 minutes. The resultant solid was collected by filtration and washed with acetonitrile (2¡Á12 ml). The solid, which is the methylamine salt of the compound of formula IV (R1=MeNH3+), was dried under vacuum at 35 C. (3.87 g). 8% w/w aqueous sodium hydroxide (5.44 ml) was added to a stirred mixture of the methylamine salt (6.0 g) in degassed water (30 ml) at 20 C. and the mixture was stirred for one hour. The mixture was filtered and concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (24 ml) was added and the mixture again concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (30 ml) was added and a solution of calcium chloride dihydrate (1.03 g) in water (6 ml) was added dropwise at 20 C. The mixture was stirred for 45 minutes and the resultant solid filtered. The solid was washed with water (36 ml) and dried under vacuum at 40 C. to give the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid.

Statistics shows that 289042-12-2 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.

Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, blongs to pyrimidines compound. Safety of tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

10 g of tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4′-fluorophenyl)-6-isoIrIpyl-2- (methylamino)pyrimidin-5-yl)vinyl)-2,2-dimethyl- 1 ,3 -dioxan-4-yl)acetate of formula (4) and 100 mL of methylene dichloride was taken into 500 mL RBF. 25 g of triethylamine was added into the reaction mixture at 250C to 35AC. The reaction mixture was cooled to get -2O0C to -250C and treated with methane sulphonyl chloride. After maintaining for 1 hour under stirring, upon completion of reaction on TLC, the reaction mixture is quenched into 100 gm ice at 00C to 50C. Separated organic layer was washed with water and 80% methylene dichloride was distilled atmospherically at 4O0C to 500C. The reaction mixture was treated with 21 mL 10% sodium hydroxide solution and 100 mL methanol. The remaining methylene dichloride was removed azeI?lropically at 450C to 5O0C. After MDC removal, the reaction mixture was treated with 200 mL methanol and temperature was raised upto reflux for about 60AC to 650C for 6-8 hours. After the completion of the reaction on TLC, methanol was distilled under vacuum at 4O0C to 45AC.Further, the reaction mixture was treated with 20 mL of water and 50 mL of acetonitrile and cooled to O0C to 1O0C. The pH of the reaction mixture was adjusted using dil HCl at O0C to 1O0C. The organic layer was separated and treated with n-propyl amine to adjust the pH to about 8 to 9 at O0C to 1O0C. The reaction mixture was maintained at about 25AC to 350C for 1 hour. The product thus obtained was filtered and washed with chilled with acetonitrile. The solid was dried at 5O0C to 550C to obtain n-propyl amine salt of 2-((4R,6S)-6-((E)-2-(4-(4′-fluoroIhenyl)-6-isoIroIyl-2-(N- mI-thylmethylsulfonamido)pyriniidin-5-yl)vinyl)-2,2-dimethyl-l,3-dioxan-4-yl) acetic acid of formula (2′).

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CADILA HEALTHCARE LIMITED; WO2009/157014; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia