Category: 28969-60-0

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28969-60-0, name is 2,5,6-Trichloropyrimidin-4-amine, molecular formula is C4H2Cl3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C4H2Cl3N3

EXAMPLE 1 This example illustrates the preparation of 4(2,3,5,6-tetrafluoro-4-trifluoromethylanilino)2,5,6-trichloropyrimidine (Comound No. 6 of Table I) having the formula: SPC1 4-Amino-2,5,6-trichloropyrimidine (1.98 g) was dissolved in dry dimethylformamide (25 cc) and the solution added dropwise to a stirred suspension of sodium hydride (0.5 g) in dry dimethylformamide (25 cc) under a nitrogen atmosphere at 0C. When the addition was complete and evolution of hydrogen had ceased a solution of octafluorotoluene (2.4 g) in dry dimethylformamide (15 cc) was added dropwise to the mixture at 0C. When this addition was complete the mixture was stirred for 30 minutes, and the temperature allowed to rise to 21C. The mixture was then poured into a mixture of iced water and salt (400 cc) and acidified with dilute hydrochloric acid. The gummy precipitate which was formed slowly hardened on standing (18 hours) and was twice recrystallized from a mixture of methylene chloride and petroleum ether (boiling range 40-60C) to yield 4(2,3,5,6-tetrafluoro-4-trifluoromethylanilino)-2,5,6-trichloropyrimidine, having a melting point of 152.4 to 153C.

With the rapid development of chemical substances, we look forward to future research findings about 28969-60-0.

Reference:
Patent; Imperial Chemical Industries Limited; US3974276; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 28969-60-0 ,Some common heterocyclic compound, 28969-60-0, molecular formula is C4H2Cl3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE A5 To a flask under argon was added 4-amino-2,5,6-trichloropyrimidine (0.08564 mol), 4-amino-benzonitrile (0.1071 mol), 1-methyl-2-pyrrolidinone (17 ml) and HCl in diethylether (1M; 85.6 ml). The mixture was placed in an oil bath at 130 C. under a stream of nitrogen until the ether was gone. An additional 10 ml of 1-methyl-2-pyrrolidinone was added. The mixture was heated at 145 C. for 16 hours under argon. 1,4-Dioxane was added. The mixture was refluxed, cooled, then filtered. The filtrate was evaporated. The residue was dissolved in CH2C1-2, washed with 1 N NaOH, then filtered. The solid was dissolved in 2-propanone, evaporated onto silica gel, and chromatographed using 1-3% 2-propanone in hexane as eluent. The pure fractions were collected and the solvent was evaporated, yielding 1.63 g (6.8%) of 4-[(4-amino-5,6-dichloro-2-pyrimidinyl)amino]benzonitrile (interm. 12).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28969-60-0, its application will become more common.

Reference:
Patent; Kukla, Michael Joseph; Ludovici, Donald William; Kavash, Robert William; De Corte, Bart Lieven Daniel; Heeres, Jan; Janssen, Paul Adriaan Jan; Koymans, Lucien Maria Henricus; de Jonge, Marc Rene; Van Aken, Koen Jeanne Alfons; Krief, Alain; US2003/186990; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia