Category: 2915-16-4

Adding a certain compound to certain chemical reactions, such as: 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-4,6-diphenylpyrimidine, blongs to pyrimidines compound. Safety of 2-Chloro-4,6-diphenylpyrimidine

First Step: Synthesis of the Compound Represented by Chemical Formula 11In a 500 mL round-bottomed flask having a thermometer, a reflux condenser, and an agitator under the nitrogen atmosphere, 6.0 g (10.72 mmol) of compound (A), 6.58 g (24.67 mmol) of compound (B), and 0.8 g (0.69 mmol) of tetrakis(triphenylphosphine)palladium were mixed with 300 mL of tetrahydrofuran, and then the mixed solution was mixed with 100 mL of 2 M potassium carbonate (K2CO3) and agitated at 80 C. for 12 hours to provide a white solid.By cooling to room temperature, the reaction was completed, and then the potassium carbonate solution was removed to filter the white solid. The filtered white solid was washed with tetrahydrofuran three times, washed with water three times, and washed with methanol three times and dried. The solid was dissolved in monochlorobenzene, active carbon was added, and the solution was agitated for 30 minutes, and the solution was filtered through a silica gel. The remaining amount of monochlorobenzene was removed to provide a white solid. The solid was filtered to provide a compound represented by Chemical Formula 11 in 7.1 g (yield: 86.2%).The obtained compound for an organic photoelectric device was analyzed by an atomic analyzer, and the results (in Atomic %) are as follows:Calculated: C, 86.02; H, 4.86; N, 9.12Found: C, 86.01; H, 4.87; N, 9.12

The synthetic route of 2915-16-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JUNG, Sung-Hyun; KANG, Myeong-Soon; JUNG, Ho-Kuk; KIM, Nam-Soo; LEE, Nam-Heon; KANG, Eui-Su; KANG, Dong-Min; CHAE, Mi-Young; US2012/256174; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4,6-diphenylpyrimidine

20 g (48.7 mmol) of the intermediate 1-4 was dissolved in 0.17 L of tetrahydrofuran (THF) under a nitrogen atmosphere, 13.0 g (48.7 mmol) of 2-chloro-4,6-diphenylpyrimidine and 1.69 g (1.46 mmol) of tetrakis(triphenylphosphine)palladium were added thereto, and the mixture was agitated. 16.8 g (122 mmol) of potassium carbonate saturated in water was added thereto, and the obtained mixture was heated and refluxed at 80 C for 6 hours. When the reaction was complete, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM) and treated with anhydrous MgSO4 to remove moisture and then, filtered and concentrated under a reduced pressure. Then, a residue obtained therefrom was separated and purified through flash column chromatography, obtaining 22.8 g (91 %) of the compound 2. (0170) HRMS (70 eV, EI+): m/z calcd for C37H26N2O: 514.2045, found: 514. (0171) Elemental Analysis: C, 86 %; H, 5 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; Cheil Industries Inc.; LEE, Han-Ill; YU, Eun-Sun; KANG, Dong-Min; KANG, Eui-Su; MIN, Soo-Hyun; YANG, Yong-Tak; OH, Jae-Jin; RYU, Dong-Kyu; LEE, Sang-Shin; JANG, Yu-Na; JEONG, Soo-Young; JO, Young-Kyoung; HAN, Su-Jin; HONG, Jin-Seok; EP2952511; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4,6-diphenylpyrimidine

20 g (48.7 mmol) of the intermediate 1-4 was dissolved in 0.17 L of tetrahydrofuran (THF) under a nitrogen atmosphere, 13.0 g (48.7 mmol) of 2-chloro-4,6-diphenylpyrimidine and 1.69 g (1.46 mmol) of tetrakis(triphenylphosphine)palladium were added thereto, and the mixture was agitated. 16.8 g (122 mmol) of potassium carbonate saturated in water was added thereto, and the obtained mixture was heated and refluxed at 80 C for 6 hours. When the reaction was complete, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM) and treated with anhydrous MgSO4 to remove moisture and then, filtered and concentrated under a reduced pressure. Then, a residue obtained therefrom was separated and purified through flash column chromatography, obtaining 22.8 g (91 %) of the compound 2. (0170) HRMS (70 eV, EI+): m/z calcd for C37H26N2O: 514.2045, found: 514. (0171) Elemental Analysis: C, 86 %; H, 5 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; Cheil Industries Inc.; LEE, Han-Ill; YU, Eun-Sun; KANG, Dong-Min; KANG, Eui-Su; MIN, Soo-Hyun; YANG, Yong-Tak; OH, Jae-Jin; RYU, Dong-Kyu; LEE, Sang-Shin; JANG, Yu-Na; JEONG, Soo-Young; JO, Young-Kyoung; HAN, Su-Jin; HONG, Jin-Seok; EP2952511; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2915-16-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below.

Under a nitrogen atmosphere, 50g (187mmol) the compound 2-chloro-4,6-diphenyl pyrimidine was dissolved in 1LTHF added thereto 37g (155mmol) (3- bromophenyl) borate, and 2.1g (1.8mmol) tetrakis (triphenylphosphine) palladium, and the mixture was stirred. Subsequently, thereto added 64g (467mmol) of potassium carbonate saturated aqueous solution, and the resulting mixture was heated at reflux for 80 12 hours. When the reaction was completed, water was added to the reaction solution, and the mixture was extracted with dichloromethane ((the DCM), followed by removal of water and dried over anhydrous MgSO4 filtered and concentrated under reduced pressure. The residue obtained was separated via flash column and chromatography to obtain 66g (92%) compound I-17.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Samsung SDI Co., Ltd.; Jin, Chengxuan; Jin, Yongquan; Liu, Dongwan; Jin, Lunhuan; Liu, Yinshan; Zheng, Chengxian; (85 pag.)CN105566200; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, molecular weight is 266.73, as common compound, the synthetic route is as follows.

After introducing compound 2-1 (4.5 g, 10 mmol), 2-chloro-4,6-diphenylpyrimidine (CAS: 29 15-16-4, 2.7 g, 10 mmol), tetrakis(triphenylphosphine)palladium (0.47 g, 0.4 mmol), potassium carbonate (3.6 g, 26 mmol), toluene (50 mL), ethanol (13 mL), and distilled water (13 mL) into a reaction vessel, the mixture was stirred for 4 hours at 120C. After completing the reaction, the mixture was added dropwise to methanol, and the obtained solid was filtered. The obtained solid was purified by column chromatography to obtain compound C-49 (4.5 g, 73 %).

Statistics shows that 2915-16-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; AHN, Hee-Choon; (41 pag.)WO2017/30283; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2915-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

After introducing compound 5-1 (10 g, 22.7 mmol), 2-chloro-4,6-diphenylpyrimidine (CAS: 2915-16-4, 5.5 g, 20.6 mmol), tetrakis(triphenylphosphine)palladium (1.2 g, 1.0 mmol), potassium carbonate (7.1 g, 56 mmol), toluene (90 mL), ethanol (30 mL), and distilled water (30 mL) into a reaction vessel, the mixture was stirred for 4 hours at 120C. After completing the reaction, the mixture was added dropwise to methanol, and the obtained solid was filtered. The obtained solid was purified by column chromatography and recrystallization to obtain compound C-87 (5.5 g, 51 %).

According to the analysis of related databases, 2915-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; AHN, Hee-Choon; (41 pag.)WO2017/30283; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2915-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Then , Under nitrogen flow at room temperature,the mixture4.08g of 9-phenyl-9H, 9’H-3,3′-dicarbazole, 2.93g of 2-chloro-4,6-diphenylpyrimidine,1.35g of Sodium tert-butoxide, 100ml of Dehydrated o-xylene were stirred. Tothe mixed solution was added 0.27 g of Tris(dibenzylideneacetone)dipalladium(0),0.16g of Tri-tert-butyl-tetrafluoroborate then heated at at 140 C and stirred for 1 hour. Carried out evaporation after the mixedsolution was directly filtered. Added200ml of methanol, refluxed for 2h and carried out filtration. The resultingsolid was purified by column chromatography on silica gel and dried in vacuo togive 5.7 g of a pale yellow powder.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; TORAY INDUSTRIES, INC.; NAGAO, KAZUMASA; TOMINAGA, TSUYOSHI; KWON, JINWOO; (86 pag.)TWI523840; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C16H11ClN2

A mixture of 2-chloro-4,6-diphenylpyrimidine, 250mg (0.94 mmol), 4- (5-CHLORO-LH-INDOL-3-YL)-4-OXO-BUTYRIC acid 2- trimethylsilanyl-ethyl ester, 380mg (1.03 mmol), K2CO3 260mg (1.87 mmol), and N, N-dimethylaminopyridine, llmg (0.09 mmol) in 20mL DMSO was heated to 80 C for 6h. The mixture was cooled to room temperature and diluted with LOOML of EtOAc. The mixture was washed with sat. aq. LiCl (3XLOOML), water (3XLOOML), sat. aq. NACL (LXLOOML), and dried (MGS04). After the solution was concentrated, the residue was purified via column chromatography (eluted with 10% EtOAc-heptane) to afford the desired product in 0.47g (88%) as a pale yellow SOLID. 1H NMR (DMSO-d6) : 6 9.39 (s, 1H), 8.87 (d, 1H, J = 9.7Hz), 8.56 (s, 1H), 8.51-8. 48 (m, 3H), 8.26 (d, 1H, J = 2.7Hz), 7.64-7. 62 (m, 5H), 7.52 (dd, 1H, 9.7, 2.7Hz), 4.10 (dd, 2H, J = 9.0, 9. OHZ), 3.40 (t, 2H, J = 7.2Hz), 2.67 (t, 2H, J = 7.2Hz), 0.94 (dd, 2H, J = 9.0, 9. 0HZ), 0.00 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC; WO2004/99159; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2915-16-4 , The common heterocyclic compound, 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

After introducing compound 4-1 (5.2 g, 12.3 mmol),2-chloro-4,6-diphenylpyrimidine (CAS: 2915-16-4, 3.3 g, 12.3 mmol), tetrakis(triphenylphosphine)palladium (0.71 g, 0.62 mmol), potassium carbonate (4.2 g, 30 mmol), toluene (60 mL), ethanol (20 mL), and distilled water (20 mL) into a reaction vessel, the mixture was stirred for 4 hours at 120C. After completing the reaction, the mixture was added dropwise to methanol, and the obtained solid was filtered. The obtained solid was purified by column chromatography and recrystallization to obtain compound C-75 (5.3 g, 82 %).

The synthetic route of 2915-16-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; AHN, Hee-Choon; (41 pag.)WO2017/30283; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

3.5 g (8.55 mmol) of an intermediate product marked as the compound A, 2.74 g (10.26 mmol) of 2-chloro-4,6-diphenyl-pyrimidine, NaH, and dimethylformamide were put in a 100 mL round flask and then, agitated at room temperature under a nitrogen flow. Next, an organic solvent therein was distillated and removed under a reduced pressure and treated through a column chromatography, separating and obtaining a compound represented by Chemical Formula 43.823 g (yield: 70%). The compound represented by Chemical Formula 4 was subjected to elemental analysis. The result is as follows. Calcd. C46H30N4: C, 86.49; H, 4.73; N, 8.77. found: C, 86.24; H, 4.89; N, 8.55.

According to the analysis of related databases, 2915-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KIM, Hyung-Sun; YU, Eun-Sun; CHAE, Mi-Young; LEE, Ho-Jae; MIN, Soo-Hyun; US2013/56720; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia