Category: 2915-16-4

Adding a certain compound to certain chemical reactions, such as: 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2915-16-4, blongs to pyrimidines compound. name: 2-Chloro-4,6-diphenylpyrimidine

A mixture of 2-chloro-4,6-diphenylpryimidine, 0. 79G (2.96 mmol), 4- (HYDROXYLMETHYL) phenylboronic acid, 0.45g (2.96 mmol), Pd (PPh3) 4,342mg (0.296 mmol), in 2 mL of toluene and 1ML of methanol was heated to obtain a clear solution. To the solution was added 2mL of 4. OM aq. NA2CO3. The reaction mixture refluxed for 16h at 70 C. The mixture was cooled to room temperature and diluted with LOOML ethyl acetate. The organic layer was washed with water, sat. aq. NaCl, and dried (MGSO4). After the solution was concentrated, the residue was recrystallized with Et20-Heptane (1 : 1) to afford the desired product in 0.38g (38%) as a yellow SOLID. 1H NMR (DMSO-d6) 8.72 (d, 2H, J = 9. 0HZ), 8.52-8. 47 (m, 4H), 8.45 (s, 1H), 7.64-7. 57 (m, 8H), 4.78 (d, 2H, J = 6.7Hz), 4.37 (t, 1H, J = 6.7Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2915-16-4, its application will become more common.

Reference:
Patent; THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC; WO2004/99171; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2915-16-4

Intermediates in a nitrogen environment I-3 (10 g, 23.1 mmol)Was dissolved in 0.1 L of tetrahydrofuran (THF), and the solution was added thereto by the Tokyo Chemical Industry (http://www.tcichemicals.com/)2-chloro-4,6-diphenylpyrimidine (6.16 g, 23.1 mmol)And tetrakis (triphenylphosphine) palladium (0.27 g, 0.23 mmol)And the mixture was stirred. Saturated water-saturated potassuim carbonate (7.98 g, 57.8 mmol) was added and heated at 80 C for 10 hours to reflux. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with dichloromethane (DCM). The extract was dried over anhydrous MgSO 4, filtered, and concentrated under reduced pressure. The residue thus obtained was separated and purified by flash column chromatography to obtain Compound 2 (10.5 g, 85%).

With the rapid development of chemical substances, we look forward to future research findings about 2915-16-4.

Reference:
Patent; Samsung SDI Co., Ltd; Lee Han-il; Ryu Eun-seon; Jeong Seong-hyeon; Han Su-jin; Kang Dong-min; Shin Chang-ju; Lee Byeong-gwan; Jeong Su-yeong; (46 pag.)KR2018/123660; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

20 g of 11-(3-(dibenzo[b,d]furan-4-yl)phenyl)-11,12-dihydroindole[2,3-a]carbazole,4. A mixture of 8 g of sodium hydride and 300 ml of toluene in a 1 liter flask,And stirred at 40 C under a nitrogen atmosphere. After one hour,Add 12. 8 g of 2-chloro-4,6-diphenyl-1,3-pyrimidine,And continue to stir at 80 C. The reaction was monitored by thin layer chromatography.After completion of the reaction, the reaction mixture was quenched with 200 ml of water,And extracted with 150 ml of ethyl acetate. The organic layer was extracted with 100 ml of water three times and dried over anhydrous sodium sulfate. The collected ethyl acetate layer was further purified by celite column chromatography. The ethyl acetate layer is followed by a rotary evaporatorIn the vacuum was evaporated to dry. The residue was further precipitated by the addition of 100 ml of n-hexane, and 18 g of a yellow solid compound F5 (85% yield) having more than 99% HPLC purity was obtained under vacuum.

According to the analysis of related databases, 2915-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; e-Ray Optoelectronics Technology Co., Ltd; Balaganesan, Banumathy; HUANG, HEH LUNG; KAU, HUANG MING; HSU, PO WEI; (22 pag.)CN106608878; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2915-16-4, Adding some certain compound to certain chemical reactions, such as: 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine,molecular formula is C16H11ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2915-16-4.

Inthe nitrogen ambient, after the compound 1-3 20 g (46.5 mmol) was melted in thetetrakis tetrahydrofuran (THF) 0.2 L here 2- chloro- 4,6- diphenylpyrimidine (2-chloro-4,6-diphenylpyrimidine)12.4 g (46.5 mmol) and tetrakis (triphenylphosphine) palladium(tetrakis(triphenylphosphine)palladium) 0.54 g (0.47 mmol) were put and itmixed. The saturated potassium carbonate 16.1 g (116 mmol) was put in water andit heated up in 80 for 15 hours and it refluxed.After water was put in into the reaction solution after the reaction completionand it extractedin the dichloromethane (DCM) moisture was removed to the anhydrous MgSO4 itfiltered and it was concentrated under reduced pressure. The residue obtainedin this way was refined to the flash column chromatography after dividing andthe compound A -14 20.4 g (82 %) was obtained.

According to the analysis of related databases, 2915-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cheil Industries Co., Ltd.; Oh, Jae Jin; Kang, Gi Wook; Kang, Uii Soo; Kim, Yun Hwan; Kim, Hun; Yang, Yong Tak; Yu, Uhn Sun; Lee, Nam Hun; Lee, Han Ir; Jo, Pyung Suk; (66 pag.)KR2015/28579; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2915-16-4 ,Some common heterocyclic compound, 2915-16-4, molecular formula is C16H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

NaH (1.9 mg, 42.1 mmol) was dissolved in dimethylformamide (DMF) in a flask and the mixture was stirred. Compound 5-2 (7.0 g, 27.2 mmol) was dissolved in DMF in a flask and added to the stirred NaH solution, and the mixture was stirred for 1 hr. 2-Chloro-4,6-diphenylpyrimidine (8.7 g, 32.6 mmol) was dissolved in DMF in a flask and stirred. The mixture stirred for 1 hr was added thereto and then stirred at room temperature for 24 hrs. After completing the reaction, the resulting solid was filtered, washed with EA, and purified by column chromatography to obtain compound H-33 (3.5 g, 25 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ROHMANDHAASELECTRONICMATERIALSKOREA LTD; LEE, KYUNG-JOO; YOON, SEOK-KEUN; KIM, CHI-SIK; KIM, HYUN; LEE, SEON-WOO; JUNG, SO-YOUNG; LEE, SU-HYUN; YANG, JEONG-EUN; KIM, YOUNG-KWANG; CHO, YOUNG-JUN; PARK, KYOUNG-JIN; JANG, SUNG-WOO; (50 pag.)TW2016/5841; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4, Adding some certain compound to certain chemical reactions, such as: 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine,molecular formula is C16H11ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2915-16-4.

Shenzhen’s gre-syn chemical technology (http://www.gre-syn.com/) in a nitrogen environment, 2-chloro-4,6-diphenylpyrimidine (20 g, 75.0 mmol) was dissolved in tetrahydrofuran (THF) 0.3 L , here it was stirred into the compound I-7 (38.1 g, 75.0 mmol) and tetrakis (triphenylphosphine) palladium (0.87 g, 0.75 mmol). Into the potassuim carbonate (25.9 g, 188 mmol) in saturated water it was heated to reflux at 80 for 15 hours. After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. The obtained residue was purified by flash column chromatography to give the Compound 9 (43.2 g, 94%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHEIL INDUSTRIES INC.; HAN ILL, LEE; SU JIN, HAN; YOUNG KWON, KIM; EUN SUN, YU; HO KUK, JUNG; (66 pag.)KR2015/117173; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4 ,Some common heterocyclic compound, 2915-16-4, molecular formula is C16H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of Compound 13 [115] Compound 1-10 (2.7 g, 10.11 mmol), Compound 1-9 (5 g, 10.11 mmol), Pd(PPh3)4 (584 mg, 0.50 mmol), K2CO3(2M) (15 mL) and EtOH (15 mL) were dissolved in toluen (30 mL), and the mixture was heated at 120 . After the mixture was stirred for 3 hours, the reaction was completed. The reaction mixture was washed with distilled water and extracted with ethylacetate. After drying an organic layer with MgSO4 and removing a solvent by the rotary type evaporator, Compound 13 (5 g, 72%) was obtained through purification by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; KIM, Hye Mi; KIM, Young Gil; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; WO2011/93609; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2915-16-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, molecular weight is 266.73, as common compound, the synthetic route is as follows.

TP2 is further reacted with 2-chloro-4,6-diphenylpyrimidine (1.0 equivalents, CAS: 2915-16-4), tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3 (0.03 equivalents; CAS 51364-51 -3), Tricyclohexylphosphine (PCy3; 0.07 equivalents, CAS 2622-14-2) and potassium phosphate tribasic (K3PO4, 1 .7 equivalents). The reaction mixture is stirred under nitrogen atmosphere in a dioxane/toluen e/water (6/1/1 ) mixture at 100 C overnight. After cooling down to room temperature (RT) the reaction mixture is extracted with DCM/brine. The organic phases are collected, washed with brine and dried over MgS04. The organic solvent is removed, the crude product was washed with cyclohexane and recrystallized from EtOH (Yield: 98%).

Statistics shows that 2915-16-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; CYNORA GMBH; SZAFRANOWSKA, Barbara; PINGEL, Patrick; BERGMANN, Larissa; AMBROSEK, David; KASPAREK, Christian; (0 pag.)WO2019/162332; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4,6-diphenylpyrimidine

To a 1 L flask was placed 11- (3- (dibenzo [b, d] furan-4-yl) phenyl) – 11,12-dihydroindolo [2,3- a] – carbazole (20 g), sodium hydride 4.8 g) and toluene (300 ml), and the mixture was stirred at 40 C. under a nitrogen atmosphere. After 1 hour, 2-chloro-4,6-diphenyl-1,3-pyrimidine (12.8 g) was added and stirring was continued at 80 F.The reaction was monitored by thin layer chromatography. After the reaction was completed, the reaction mixture was quenched with water (200 ml) and extracted using ethyl acetate (150 ml). The organic layer was extracted with water (3 ¡Á 100 ml) and dried over anhydrous sodium sulfate. For further purification, the collected ethyl acetate layer was passed through Celite column chromatography. Subsequently, the ethyl acetate layer was evaporated and dried under reduced pressure using a rotary evaporator. 100 ml of n-hexane was added, filtrated, and reduced pressure The residue was further precipitated by drying. As a yellow solid, 18 g (85%) of Compound F5 having an HPLC purity of 99% or more was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; E-RAY OPTOELECTRONICS TECHNOLOGY COMPANY LIMITED; BALAGANESAN, BANUMATHY; HUANG, HEHLUNG; GUO, HUNG MING; HSU, POWEI; (23 pag.)JP2017/31112; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2915-16-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2915-16-4 as follows.

Example 90; [4- (4, 6-Diphenylpyrimidin-2-yl) -phenyl]methanol; A mixture of 2-chloro-4, 6-diphenylpryimidine, 0.79g (2.96 mmol), 4- (hydroxylmethyl)phenylboronic acid, 0.45g (2.96 mmol), Pd (PPh3) 4, 342mg (0.296 mmol), in 2 mL of toluene and EPO ImL of methanol was heated to obtain a clear solution. To the solution was added 2mL of 4.0M aq. Na2CO3. The reaction mixture refluxed for lbetah at 70 C. The mixture was cooled to room temperature and diluted with 10OmL ethyl acetate. The organic layer was washed with water, sat. aq. NaCl, and dried (MgSO4) . After the solution was concentrated, the residue was recrystallized with Et2O-Heptane (1:1) to afford the desired product in 0.38g (38%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2915-16-4, its application will become more common.

Reference:
Patent; THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC; WO2006/55725; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia