Category: 2927-71-1

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Related Products of 2927-71-1.

Raubo, Piotr;Carbajo, Rodrigo J.;McCoull, William;Raubo, Joanna;Thomas, Morgan research published 《 Diversity-orientated synthesis of macrocyclic heterocycles using a double S_NAr approach》, the research content is summarized as follows. An efficient macrocyclization approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodol. allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of a significant number of structurally diverse macrocycles e.g., I. SNACK macrocyclization enables preparation of stable diastereoisomers of conformationally restricted macrocycles (atropisomers) e.g., II and e.g., III. Practical application of SNACK macrocyclization in a drug discovery project was exemplified by the identification of high affinity macrocyclic binders of B-cell lymphoma 6 (BCL6).

Related Products of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Ren, Jing;Shi, Wei;Zhao, Damin;Wang, Qinglin;Chang, Xiayun;He, Xiangyi;Wang, Xiaojin;Gao, Yong;Lu, Peng;Zhang, Xiquan;Xu, Hongjiang;Zhang, Yinsheng research published 《 Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors》, the research content is summarized as follows. Bruton’s tyrosine kinase (BTK) and Janus kinase 3 (JAK3) are very promising targets for hematol. malignancies and autoimmune diseases. In recent years, a few compounds have been approved as a marketed medicine, and several are undergoing clin. trials. By recombining the dominant backbone of known active compounds, constructing a focused library, and screening a broad panel of kinases, we found a class of compounds with dual activities of anti-BTK and anti-JAK3. Some of the compounds have shown 10-folds more active in the enzyme and cell-based assays than a known active compound Furthermore, liver microsome stability experiments show that these compounds have better stability than ibrutinib. These explorations offered new clues to discover benzoxaborole fragment and pyrimidine scaffold as more effective BTK and JAK3 dual inhibitors.

Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Application of C4HCl2FN2.

Pan, Tao;Dan, Yanrong;Guo, Dafeng;Jiang, Junhao;Ran, Dongzhi;Zhang, Lin;Tian, Binghua;Yuan, Jianyong;Yu, Yu;Gan, Zongjie research published 《 Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC》, the research content is summarized as follows. Combination of anaplastic lymphoma kinase (ALK) inhibitor with histone deacetylases (HDAC) inhibitor could exert synergistically anti-proliferative effects on ALK pos. non-small cell lung cancer (NSCLC) naive or resistant cells. In this work, we designed and synthesized a series of 2,4-pyrimidinediamine derivatives as dual ALK and HDAC inhibitors based on pharmacophore merged strategy. Among which, compound I displayed the most potent and balanced inhibitory activity against ALK (IC₅₀ = 2.1 nM) and HDAC1 (IC₅₀ = 7.9 nM), resp. In particular, I was also potent against the frequently observed Crizotinib-resistant ALK^L1196M (IC₅₀ = 1.7 nM) as well as the Ceritinib-resistant ALK^G1202R (IC₅₀ = 0.4 nM) mutants. In antiproliferative activity assay, I exhibited impressive activity on ALK-addicted cancer cell lines at low micromole concentrations, which was comparable to that of Crizotinib and Ceritinib. Further flow cytometric anal. indicated that I could effectively induce cell death via cell apoptosis and cell cycle arrest. Taken together, these results suggested I would be a promising lead compound for the ALK-pos. NSCLC treatment, especially the Ceritinib- or Crizotinib-resistant NSCLC.

Application of C4HCl2FN2, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Formula: C4HCl2FN2.

McCoull, William;Hennessy, Edward J.;Blades, Kevin;Chuaqui, Claudio;Dowling, James E.;Ferguson, Andrew D.;Goldberg, Frederick W.;Howe, Nicholas;Jones, Christopher R.;Kemmitt, Paul D.;Lamont, Gillian;Varnes, Jeffrey G.;Ward, Richard A.;Yang, Bin research published 《 Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors》, the research content is summarized as follows. Group I p21-activated kinase (PAK) inhibitors are indicated as important in cancer progression, but achieving high kinase selectivity has been challenging. A bis-anilino pyrimidine PAK1 inhibitor was identified and optimized through structure-based drug design to improve PAK1 potency and achieve high kinase selectivity, giving in vitro probe compound AZ13705339 (18). Reduction of lipophilicity to lower clearance afforded AZ13711265 (14) as an in vivo probe compound with oral exposure in mouse. Such probes will allow further investigation of PAK1 biol.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Formula: C4HCl2FN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Product Details of C4HCl2FN2.

Merritt, Jeremy M.;Borkar, Indrakant;Buser, Jonas Y.;Brewer, Alison Campbell;Campos, Odilon;Fleming, Jeffrey;Hansen, Caoimhe;Humenik, Ashley;Jeffery, Stephen;Kokitkar, Prashant B.;Kolis, Stanley P.;Forst, Mindy B.;Lambertus, Gordon R.;Martinelli, Joseph R.;McCartan, Ciaran;Moursy, Hossam;Murphy, Donal;Murray, Michael M.;O’Donnell, Kevin;O’Sullivan, Rita;Richardson, Gary A.;Xia, Han research published 《 Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations》, the research content is summarized as follows. The hazard assessment of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis(pinacolato)diboron (BisPin), used in the developmental synthesis of an intermediate for abemaciclib, led to the observation of hydrogen being generated. Quant. headspace GC and solution ¹¹B NMR were used to show that the rapid decomposition of the excess BisPin from the borylation under the aqueous basic conditions of the Suzuki reaction was responsible for H₂ generation. The moles of H₂ observed were found equal to the BisPin excess, which is rationalized by mass balance and a stoichiometric reaction. The possible generation of the stoichiometric levels of H₂ should be considered in hazard assessments of this class of reaction. Kinetic and process modeling was used to minimize the risk upon scale-up, and results for com. manufacturing batches are presented, which showed good agreement with the lab scale data. Furthermore, the hydrogen evolution potentials of other common borylating agents including bisboronic acid (BBA) and pinacol borane were demonstrated.

Product Details of C4HCl2FN2, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. SDS of cas: 2927-71-1.

Mujumdar, Prashant;Sarnpitak, Pakornwit;Shetnev, Anton;Dorogov, Mikhail;Krasavin, Mikhail research published 《 Facile Pd-catalyzed amination of imidazolin-1-yl chloroazines under microwave irradiation: toward a new kinase-inhibitory chemotype》, the research content is summarized as follows. An imidazolinyl-azine moiety, constructed using a recently developed Buchwald-Hartwig-type arylation methodol., displays excellent chem. stability under subsequent microwave-assisted Pd-catalyzed amination with a range of N-nucleophiles. This finding extends the use of imidazolinyl-azines for a bioactive compound library design. The latter is exemplified herein by the discovery of micromolar kinase inhibitors. The title compounds thus formed included 2,4-bis(1H-imidazol-1-yl)pyrimidine derivatives and (imidazolyl)pyrazine derivatives and related substances. The synthesis of the target compounds was achieved by a reaction of imidazole derivatives, such as 2-(4,5-dihydro-1H-imidazol-2-yl)pyridine, 2-(2-furanyl)-4,5-dihydro-1H-imidazole, 2-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-1H-indole with (chloro)azine derivatives, such as 2,6-dichloropyrazine, 2,4-dichloro-5-fluoropyrimidine.

SDS of cas: 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Name: 2,4-Dichloro-5-fluoropyrimidine.

Luecking, Ulrich;Kosemund, Dirk;Boehnke, Niels;Lienau, Philip;Siemeister, Gerhard;Denner, Karsten;Bohlmann, Rolf;Briem, Hans;Terebesi, Ildiko;Boemer, Ulf;Schaefer, Martina;Ince, Stuart;Mumberg, Dominik;Scholz, Arne;Izumi, Raquel;Hwang, Stuart;von Nussbaum, Franz research published 《 Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer》, the research content is summarized as follows. Selective inhibition of exclusively transcription-regulating pos. transcription elongation factor b/CDK9 is a promising new approach in cancer therapy. Starting from atuveciclib, the first selective CDK9 inhibitor to enter clin. development, lead optimization efforts aimed at identifying i.v. (iv) applicable CDK9 inhibitors with an improved therapeutic index led to the discovery of the highly potent and selective clin. candidate VIP152 (I). The evaluation of various scaffold hops was instrumental in the identification of VIP152, which is characterized by the underexplored benzyl sulfoximine group. VIP152 exhibited the best preclin. overall profile in vitro and in vivo, including high efficacy and good tolerability in xenograft models in mice and rats upon once weekly iv administration. VIP152 has entered clin. trials for the treatment of cancer with promising longterm, durable monotherapy activity in double-hit diffuse large B-cell lymphoma patients.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Name: 2,4-Dichloro-5-fluoropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Category: pyrimidines.

Ma, You-Zhen;Tang, Zhen-Bo;Sang, Chun-Yan;Qi, Zhi-Yuan;Hui, Ling;Chen, Shi-Wu research published 《 Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors》, the research content is summarized as follows. To find novel effective Aurora kinases inhibitors, a series of structurally interesting nitroxide labeled pyrimidines I (R = cyclopentylamino, morpholin-4-yl, 3-[(4-nitrophenyl)amino]propylamino, etc.; R¹ = NO₂, F) was synthesized and evaluated for their anti-proliferative and Aurora kinases inhibitory activities. Among them, I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R¹ = F) possessed the most potent anti-proliferative effects against four carcinoma cell lines with IC₅₀ values in range of 0.89-11.41 μM, and kinases inhibition against Aurora A and B with the IC₅₀ values were 9.3 and 2.8 nM, resp. Furthermore, I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R¹ = F) blocked the phosphorylation of Aurora A (T288), Aurora B (Thr232) and HisH3, decreased the expression of proteins TPX2, Eg5 and Bora, as well as disrupted the mitotic spindle formation in HeLa cells. Mol. docking studies indicated that I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R¹ = F) well interact with both Aurora A and B. The results showed that I (X = F; R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl) is a potential anticancer agent as promising pan-Aurora kinase inhibitor.

Category: pyrimidines, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Synthetic Route of 2927-71-1.

Mandal, Mihirbaran;Wu, Yusheng;Misiaszek, Jeffrey;Li, Guoqing;Buevich, Alexei;Caldwell, John P.;Liu, Xiaoxiang;Mazzola, Robert D.;Orth, Peter;Strickland, Corey;Voigt, Johannes;Wang, Hongwu;Zhu, Zhaoning;Chen, Xia;Grzelak, Michael;Hyde, Lynn A.;Kuvelkar, Reshma;Leach, Prescott T.;Terracina, Giuseppe;Zhang, Lili;Zhang, Qi;Michener, Maria S.;Smith, Brad;Cox, Kathleen;Grotz, Diane;Favreau, Leonard;Mitra, Kaushik;Kazakevich, Irina;McKittrick, Brian A.;Greenlee, William;Kennedy, Matthew E.;Parker, Eric M.;Cumming, Jared N.;Stamford, Andrew W. research published 《 Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates》, the research content is summarized as follows. We describe successful efforts to optimize the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented by 6 that embodies the recently validated fused pyrrolidine iminopyrimidinone scaffold. Employing structure-based design, truncation of the cyanophenyl group of I that binds in the S3 pocket of BACE1 followed by modification of the thienyl group in S1 was pursued. Optimization of the pyrimidine substituent that binds in the S2′-S2” pocket of BACE1 remediated time-dependent CYP3A4 inhibition of earlier analogs in this series and imparted high BACE1 affinity. These efforts resulted in the discovery of difluorophenyl analog II (MBi-4), which robustly lowered CSF and cortex Aβ₄₀ in both rats and cynomolgus monkeys following a single oral dose. II represents a unique mol. shape among BACE inhibitors reported to potently lower central Aβ in nonrodent preclin. species.

Synthetic Route of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Safety of 2,4-Dichloro-5-fluoropyrimidine.

Mandal, Mihirbaran;Mitra, Kaushik;Grotz, Diane;Lin, Xinjie;Palamanda, Jairam;Kumari, Pramila;Buevich, Alexei;Caldwell, John P.;Chen, Xia;Cox, Kathleen;Favreau, Leonard;Hyde, Lynn;Kennedy, Matthew E.;Kuvelkar, Reshma;Liu, Xiaoxiang;Mazzola, Robert D.;Parker, Eric;Rindgen, Diane;Sherer, Edward;Wang, Hongwu;Zhu, Zhaoning;Stamford, Andrew W.;Cumming, Jared N. research published 《 Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety》, the research content is summarized as follows. Herein the authors describe structure-activity relationship (SAR) and metabolite identification (Met-ID) studies that provided insight into the origin of time-dependent inhibition (TDI) of cytochrome P 450 3A4 (CYP3A4) by compound I. Collectively, these efforts revealed that bioactivation of the fluoropyrimidine moiety of I led to reactive metabolite formation via oxidative defluorination and was responsible for the observed TDI. The authors discovered that substitution at both the 4- and 6-positions of the 5-fluoropyrimidine of I was necessary to ameliorate this TDI as exemplified by compound II.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Safety of 2,4-Dichloro-5-fluoropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia