Category: 29458-38-6

Moreno-Manas, Marcial; Pleixats, Roser; Villarroya, Merce published an article on February 12 ,1993. The article was titled 《Palladium-catalyzed allylation of pyrimidine-2,4-diones (uracils) and of 6-membered heterocyclic ambident sulfur nucleophiles》, and you may find the article in Tetrahedron.Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione The information in the text is summarized as follows:

Pd(0)-catalyzed allylation of six-membered ambident heterocycles (e.g., 2-pyridone, 6-methyl-2-thiouracil, and 2-thiobarbituric acid) bearing NH-CO, NH-CS and CH2-CO moieties obey the regioselectivity rules: C > O; N > O; S > H, NH-CO > NH-CS. Uracil and 5-methyluracil (thymine) do not show regioselectivity (N-1 = N-3) whereas 6-methyluracil is regioselectively allylated at N-3 (N-3 > N-1). In addition to this study using 6-Methoxypyrimidine-2,4(1H,3H)-dione, there are many other studies that have used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione) was used in this study.

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C5H6N2O3On November 20, 1995 ,《Metabolism of ALS inhibitory herbicide Bispyribac-sodium [KIH-2023] in rats》 appeared in Nippon Noyaku Gakkaishi. The author of the article were Fukai, Yasushi; Unai, Tadaaki; Ishikawa, Kanji; Yusa, Yoshio; Wada, Nobuhide; Tezuka, Masakatsu; Okada, Shoji. The article conveys some information:

Absorption, distribution and metabolism of Bispyribac-sodium [sodium 2,6-bis(4,6-dimethoxypyrimidin-2-yloxy)benzoate] or [KIH-2023] in rats orally dosed with 14C-KIH-2023 were investigated. More than 90% of the dosed radioactivity was detected in the excreta within 96 h after dosing. Level of the radioactivity in the blood of male and female rats reached maximum at 2 and 1 h after dosing, resp., and then decreased rapidly to about a half level of maximum (C1/2). The radioactivity of tissues was lower at 96 h after dosing than that at C1/2-time. Most of the radioactivity in the urine, feces, liver, and plasma was detected as unchanged KIH-2023. The major radioactive compounds excreted into the bile were KIH-2023 and its glucuronide. Repeated oral administration of KIH-2023 for 15 days gave similar results from the single oral one in the excretion, tissue distribution and metabolism of 14C-KIH-2023. In the experiment, the researchers used many compounds, for example, 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6COA of Formula: C5H6N2O3)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1972,Canadian Journal of Chemistry included an article by Neville, G. A.; Avdovich, H. W.. Name: 6-Methoxypyrimidine-2,4(1H,3H)-dione. The article was titled 《Isomeric pyrimidone and uracil derivatives obtained by reaction of barbiturates with diazomethane》. The information in the text is summarized as follows:

Studies of the action of CH2N2 on barbituric acid, 1-methylbarbituric acid, and 5-ethyl-and 5-phenylbarbituric acids resulted in assignment of structures for possible positional isomers. The results came from multiple reactions, including the reaction of 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Name: 6-Methoxypyrimidine-2,4(1H,3H)-dione)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 6-Methoxypyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 29458-38-6On October 31, 1978 ,《O-Methylation of barbituric acids》 appeared in Farmaco, Edizione Scientifica. The author of the article were Stankiewicz, K.; Bobranski, B.. The article conveys some information:

Treating barbituric and N-phenylbarbituric acid with dry HCl in MeOH at room temperature gave 77.4% I (R = H) and 85% I (R = Ph), resp. In the part of experimental materials, we found many familiar compounds, such as 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Application of 29458-38-6)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 29458-38-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Formula: C5H6N2O3On September 8, 2022 ,《Fragment Ligands of the m6A-RNA Reader YTHDF2》 was published in ACS Medicinal Chemistry Letters. The article was written by Nai, Francesco; Nachawati, Raed; Zalesak, Frantisek; Wang, Xiang; Li, Yaozong; Caflisch, Amedeo. The article contains the following contents:

17 Small-mol. ligands that compete with N6-methyladenosine (m6A) for binding to the m6A-reader domain of YTHDF2 (YT521-B homol. domain family 2) was reported. Their binding mode at high resolution was determined by X-ray crystallog. and their affinity was quantified by a fluorescence-based binding assay. 6-Cyclopropyluracil and a pyrazolopyrimidine derivative had favorable ligand efficiencies of 0.47 and 0.38 kcal mol-1 per non-hydrogen atom, resp. They represent useful starting points for hit optimization. In addition to this study using 6-Methoxypyrimidine-2,4(1H,3H)-dione, there are many other studies that have used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Formula: C5H6N2O3) was used in this study.

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dioneOn May 4, 2006 ,《On the Electron Donor and the Electrophilic Substitution Activating Abilities of Substituents in Uracil》 appeared in Journal of Physical Chemistry A. The author of the article were Gonzalez Moa, Maria J.; Mosquera, Ricardo A.. The article conveys some information:

QTAIM properties for uracil and 18 derivatives containing the substituents -NH2, -OH, -OCH3, -SH, -F, -Cl, -CH3 -NO2, and -Li in position 5 or 6 were computed on MP2/6-31++G**//MP2/6-31G** charge densities. The results indicate that -OH, -OCH3, and -NH2 groups are really retrieving charge from the ring. Also, the activating ability of the substituent groups, usually considered as the variation of electron population at the carbon where the electrophilic attack takes place, C*, was studied. The study shows that the activating ability is reflected by the variation of π charge or quadrupole moment at C*, and also by the variation of the Laplacian of the charge d. in the secondary charge concentration points around C* (SCC-C*). They indicate a similar, but not exactly equal, graduation of activating ability. The relative behavior of the substituents is basically the same as in benzene, though benzene has more tendency to concentrate charge in the SCC-C* regions than uracil, where this tendency is larger for 6- than for 5-derivatives σ+/-R Taft parameters are found to display good correlations with the above indicated activating indexes. Finally, the resonance model predicts most of the main variations displayed by QTAIM at. π electron populations of derivatives with regard to uracil, but there are still some significant variations of the π electron charge that it cannot predict. In the experiment, the researchers used many compounds, for example, 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dione)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Quality Control of 6-Methoxypyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1968,Journal of Pharmaceutical Sciences included an article by Venturella, Vincent S.. Safety of 6-Methoxypyrimidine-2,4(1H,3H)-dione. The article was titled 《Selective acid-catalyzed hydrolyses of methoxysulfanilamidodiazines》. The information in the text is summarized as follows:

The dilute acid hydrolysis of 3-methoxy-6-sulfanilamidopyridazine and several methoxysulfanilamidopyrimidines was studied. Experiments show that in cases where an intermediate 2-pyrimidone is a possible postulation, further hydrolysis usually leads to the formation of sulfanilamide and the corresponding hydroxypyrimidine. A multistage route for the acidic degradation of 3-methoxy-6-sulfanilamidopyridazine, 2,4-dimethoxy-6-sulfanilamidopyrimidine, and 2-methylthio-4-methoxy-6-sulfanilamidopyrimidine is proposed. 26 references. In the experimental materials used by the author, we found 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Safety of 6-Methoxypyrimidine-2,4(1H,3H)-dione)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Safety of 6-Methoxypyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sharma, Ashok K.; Wen, Lian; Hall, Larry R.; Allan, John G.; Clark, Brett J. published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《Metabolism of Pyrithiobac Sodium in Soils and Sediment, Addressing Bound Residues via Kinetics Modeling》.Related Products of 29458-38-6 The author mentioned the following in the article:

Degradation of pyrithiobac sodium (PE350) was examined in a number of soils and sediments using 14C-PE350. It degrades primarily via microbial degradation which leads to the separation of the two rings of the mol. Identification of several metabolites, many of which were minor products, helped to understand the formation of nonextractable residues (NER) and 14CO2. In all studies, unextractable residues accounted for a large portion (20-60%) of the residues. Traditional kinetics modeling treats NER and CO2 as a single compartment, stated as sink, and formation mechanism of such components individually is ignored. Since studies conducted with radiolabeled test substance provides an accurate measurement of NER and CO2, we have demonstrated that kinetics modeling with these compartments sep. can be used to clarify degradation pathways, including the origin of NER and CO2. This work demonstrated that overall metabolism in soils and sediments proceeded via similar pathways, and kinetics modeling was useful in clarifying the degradation route and formation of NER in all studies. In the experimental materials used by the author, we found 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Related Products of 29458-38-6)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 29458-38-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Azoles and azines: CVII. Synthesis of 5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones and their 2,8-dithio analogs》 was written by Moskvin, A. V.; Polkovnikova, I. I.; Ivin, B. A.. Formula: C5H6N2O3 And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) on August 31 ,1998. The article conveys some information:

5H-Pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones were prepared by treatment with a POCl3-P2O5 mixture of pyridinium salts of 5,5′-arylmethylenebisbarbituric acids or by condensation of 6-methoxyuracil with aromatic aldehydes or formaldehyde, followed by demethylation of intermediate 4,6-dimethoxy-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,8(1H,9H)-diones. 2,8-Dithioxo-1,2,3,4,6,7,8,9-octahydro-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-4,6-diones are formed by reaction of pyridinium salts of 5,5′-arylmethylenebis(2-thiobarbituric) acids with trifluoroacetic anhydride. After reading the article, we found that the author used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Formula: C5H6N2O3)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia