Category: 29939-37-5

Application of 29939-37-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29939-37-5, name is 4-Hydroxy-6-hydrazinylpyrimidine. A new synthetic method of this compound is introduced below.

A mixture comprising 5.0 g (39.6 mmol) 6-hydrazinopyrimidin-4-ol/6- hydrazinopyrimidin-4(1 H)-one (CAS-No: 29939-37-5), 5.12 g pentan-3-one and 80.8 mL ethanol was heated under reflux for 2 hours. After cooling to 3C, the precipitated solid was filtered off and washed with diethyl ether to give 5.82 g (72%) of the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29939-37-5, 4-Hydroxy-6-hydrazinylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; WORTMANN, Lars; KETTSCHAU, Georg; PUeHLER, Florian; LIENAU, Philip; PETERSEN, Kirstin; HAeGEBARTH, Andrea; SUeLZLE, Detlev; GRAHAM, Keith; RICHTER, Anja; WO2014/48869; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 29939-37-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29939-37-5, name is 4-Hydroxy-6-hydrazinylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Example 1c 6-(2-Cyclohexylidenehydrazino)pyrimidin-4-ol A mixture comprising 240 mg (1.90 mmol) 6-hydrazinopyrimidin-4-ol/6- hydrazinopyrimidin-4(1 H)-one (CAS-No: 29939-37-5), 280 mg cyclohexanone and 3.88 mL ethanol was heated under reflux for 1.5h. After cooling to 3C, the precipitated solid was filtered off and washed with diethyl ether to give 354.1 mg (86%) of the title compound.

According to the analysis of related databases, 29939-37-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; KETTSCHAU, Georg; SUeLZLE, Detlev; PUeHLER, Florian; KOSEMUND, Dirk; LIENAU, Philip; BOeMER, Ulf; WO2013/174743; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 29939-37-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29939-37-5, name is 4-Hydroxy-6-hydrazinylpyrimidine, molecular formula is C4H6N4O, molecular weight is 126.12, as common compound, the synthetic route is as follows.

A mixture comprising 5.0 g (39.6 mmol) 6-hydrazinopyrimidin-4-ol/6-hydrazinopyrimidin-4(1H)-one (CAS-No: 29939-37-5), 5.12 g pentan-3-one and 80.8 ml ethanol was heated under reflux for 2 hours. After cooling to 3 C, the precipitated solid was filtered off and washed with diethyl ether to give 5.82 g (72%) of the title compound.

Statistics shows that 29939-37-5 is playing an increasingly important role. we look forward to future research findings about 4-Hydroxy-6-hydrazinylpyrimidine.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; WORTMANN, Lars; KETTSCHAU, Georg; PUeHLER, Florian; LIENAU, Philip; PETERSEN, Kirstin; HAeGEBARTH, Andrea; SUeLZLE, Detlev; WO2014/44691; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 29939-37-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 29939-37-5 as follows.

A mixture comprising 5.0 g (39.6 mmol) 6-hydrazinopyrimidin-4-ol/6-hydrazinopyrimidin- 4(1 H)-one (CAS-No: 29939-37-5), 5.12 g pentan-3-one and 80.8 mL ethanol was heated under reflux for 2 hours. After cooling to 3C, the precipitated solid was filtered off and washed with diethyl ether to give 5.82 g (72%) of the title compound

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29939-37-5, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; WORTMANN, Lars; KETTSCHAU, Georg; GRAHAM, Keith; RICHTER, Anja; LIENAU, Philip; PUEHLER, Florian; PETERSEN, Kirstin; SIEGEL, Franziska; SUeLZLE, Detlev; WO2015/4024; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 29939-37-5, 4-Hydroxy-6-hydrazinylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 29939-37-5, blongs to pyrimidines compound. Product Details of 29939-37-5

PREPARATION 3phenylmethyl 4-chloro-1 ,5,7,8-tetrahydro-6/-/-pyrido[3′,4′:4,5]pyrrolo[2,3-c/]pyricarboxylateStep 1 . phenylmethyl 4-[(6-oxo-1 ,6-dihydro-4-pyrimidinyl)hydrazono]-1- piperidinecarboxylateA suspension of 6-hydrazino-4(1 H)-pyrimidinone (0.966 g, 7.66 mmol) in ethanol(20 mL) and phenylmethyl 4-oxo-1 -piperidinecarboxylate (2.68 g, 1 1 .49 mmol) were heated in a 76 C oil bath for 3 hours. The reaction mixture was cooled in an ice-water bath before the solids were collected by filtration and dried under high vacuum over night to afford phenylmethyl 4-[(6-oxo-1 ,6-dihydro-4-pyrimidinyl)hydrazono]-1- piperidinecarboxylate (1 .53 g, 58%) as white solid MS (m/z) 342.1 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29939-37-5, 4-Hydroxy-6-hydrazinylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXOSMITHKLINE LLC; HAMMOND, Marlys; ZHAO, Yongdong; WO2011/56739; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia