Category: 3001-72-7

Application of 3001-72-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The p-nitrophenyl carbonate derivative (0.3 g) was dissolved in AR grade THF (5 mL) at room temperature and DBU or DBN (2 equiv) was added. The temperature of the reaction mixture was raised to 60 C and stirring was continued for 1 h. After completion, the reaction mixture was extracted with ethyl acetate (2 × 30 mL), the organic layer washed with saturated NaHCO3 solution, water, brine and dried over anhydrous Na2SO4. Thesolvent was evaporated and the crude compound was purified by column chromatography

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine.

Reference:
Article; Vangala, Madhuri; Shinde, Ganesh P.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2086 – 2092;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3001-72-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3001-72-7 as follows.

General procedure: A mixture of dimethyl 3-amino-4-cyano-9H-fluorene-1,2-dicarboxylate (1 mmol), carbon disulfide (3 mmol) andDBU or DBN (1 mmol) in DMF (1.5 mL) was stirred for12 h in room temperature. After completion of the reaction(confirmed by TLC), the solvent was removed underreduced pressure. The residue was washed with water (5 ml)and recrystallized from EtOH to afford the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Ahadi, Somayeh; Zolghadr, Mahdi; Shakibaei, Ghazaleh Imani; Bazgir, Ayoob; Journal of the Iranian Chemical Society; vol. 13; 2; (2016); p. 369 – 375;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3001-72-7, Adding some certain compound to certain chemical reactions, such as: 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine,molecular formula is C7H12N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3001-72-7.

EXAMPLE 1 13 g of diethyl 2,2-dimethyl-3-(2′,2′-dichlorovinyl)-cyclopropane-1,1-dicarboxylate were dissolved in 50 g of o-xylene and 20 g of 1,5-diaza-bicyclo[4.3.0]non-5-ene were added. The mixture was then heated to the boil for 8 hours. After cooling, ice-cold dilute hydrochloric acid was added, so that a neutral or weakly acid pH value resulted. The organic phase was separated off and dried with Na2 SO4 and the xylene was distilled off in vacuo (boiling point = 35 – 40 C./12 mm Hg). The residue weighed 12.5 g. Fractional distillation gave 4.7 g of 2,2-dimethyl-3-(2′,2′-dichlorovinyl)-cyclopropane-1-carboxylic acid ethyl ester, of which 30% was in the cis form and 70% was in the trans form. The boiling point was 65 – 72 C./0.3 mm Hg. The nuclear magnetic resonance spectrum agreed with that given in the literature. 6.5 g of the starting material were recovered. The yield was thus 92%.

According to the analysis of related databases, 3001-72-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Aktiengesellschaft; US4113969; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3001-72-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3001-72-7 as follows.

General procedure: The reaction mixture of azlactones 1a-p (0.2mmol) and DBN (2b, 0.03mL, 0.22mmol) was stirred at room temperature for the appropriate time according to Scheme 2. After completion of the reaction as monitored by TLC (eluent: petroleum ether/ethyl acetate, 4:1), the mixture was extracted with ethyl acetate (3×5mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by silica gel column chromatography (10-35% ethyl acetate in petroleum ether) afforded the products 3ab-pb.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Rudbari, Hadi Amiri; Tetrahedron; vol. 73; 11; (2017); p. 1397 – 1406;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, molecular weight is 124.1836, as common compound, the synthetic route is as follows.Safety of 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine

General procedure: The p-nitrophenyl carbonate derivative (0.3 g) was dissolved in AR grade THF (5 mL) at room temperature and DBU or DBN (2 equiv) was added. The temperature of the reaction mixture was raised to 60 C and stirring was continued for 1 h. After completion, the reaction mixture was extracted with ethyl acetate (2 × 30 mL), the organic layer washed with saturated NaHCO3 solution, water, brine and dried over anhydrous Na2SO4. Thesolvent was evaporated and the crude compound was purified by column chromatography

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Vangala, Madhuri; Shinde, Ganesh P.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2086 – 2092;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3001-72-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

N-methyl-1,5-diazabicyclo[4.3.0]non-5-enium dimethyl phosphate ([mDBN][Me2PO4]) was prepared using a Syrris glass-jacketed reactor. For a 250g batch of [mDBN][Me2PO4] the following method was used: 116.89ml (0.946mol) of DBN was charged to the reactor followed by flushing the headspace with argon gas. 110.71ml (0.946mol) of trimethyl phosphate was added to the DBN at 60C under argon atmosphere, as to keep the temperature below 80C during the exothermic reaction. The mixture was then heated to 75C where it was kept for one hour and then cooled to room temperature. The product was an oil-like yellow liquid (Fig. 1).

According to the analysis of related databases, 3001-72-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Parviainen, Helena; Parviainen, Arno; Virtanen, Tommi; Kilpelaeinen, Ilkka; Ahvenainen, Patrik; Serimaa, Ritva; Groenqvist, Stina; Maloney, Thaddeus; Maunu, Sirkka Liisa; Carbohydrate Polymers; vol. 113; (2014); p. 67 – 76;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3001-72-7 , The common heterocyclic compound, 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a pressure-resistant container equipped with a stirrer,162 parts (0.89 mol) of triethyl phosphate (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) (A-1)130 parts (1.78 mol) of diethylamine (manufactured by BASF) (B-1) were charged, and the temperature was raised to 125 C. The reaction was allowed to continue for 30 hours with stirring. After cooling, the P-NMR of the reaction solution was measured. As a result, the peak of triethyl phosphate disappeared and only the peak of diethyl phosphate appeared. 260 parts (0.9 mol) of a methanol solution of 1,2,3,4-tetramethylimidazolium methyl carbonate (J-1) was added to this reaction solution for salt exchange. This solution was concentrated under reduced pressure at 100 C. using a rotary evaporator to obtain a yellow-brown solid. It was confirmed by 1 H-NMR and P-NMR that this yellowish brown solid was 1,2,3,4-tetramethylimidazolium diethylphosphate (K-1). In Example 1, 260 parts of a 1,2,3,4-tetramethylimidazolinium methyl carbonate salt methanol solution was changed to 112 parts ((0.9 mol)) of 1,5-diazabicyclo [4.3.0] -5-nonene (E-1 ), a yellow brown liquid was obtained in the same manner as in Example 1. It was confirmed by 1 H-NMR and P-NMR that this yellow-brown solid was 1,5-diazabicyclo [4.3.0] -5-nonenium diethyl phosphate (F-1).

The synthetic route of 3001-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANYO CHEMICAL INDUSTRIES LIMITED; SHIRAISHI, ATSUSHI; (21 pag.)JP5647820; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3001-72-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, molecular weight is 124.1836, as common compound, the synthetic route is as follows.

General procedure: The reaction mixture of azlactones 1a-p (0.2mmol) and DBN (2b, 0.03mL, 0.22mmol) was stirred at room temperature for the appropriate time according to Scheme 2. After completion of the reaction as monitored by TLC (eluent: petroleum ether/ethyl acetate, 4:1), the mixture was extracted with ethyl acetate (3×5mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by silica gel column chromatography (10-35% ethyl acetate in petroleum ether) afforded the products 3ab-pb.

Statistics shows that 3001-72-7 is playing an increasingly important role. we look forward to future research findings about 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine.

Reference:
Article; Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Rudbari, Hadi Amiri; Tetrahedron; vol. 73; 11; (2017); p. 1397 – 1406;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3001-72-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine. A new synthetic method of this compound is introduced below.

General procedure: The p-nitrophenyl carbonate derivative (0.3 g) was dissolved in AR grade THF (5 mL) at room temperature and DBU or DBN (2 equiv) was added. The temperature of the reaction mixture was raised to 60 C and stirring was continued for 1 h. After completion, the reaction mixture was extracted with ethyl acetate (2 × 30 mL), the organic layer washed with saturated NaHCO3 solution, water, brine and dried over anhydrous Na2SO4. Thesolvent was evaporated and the crude compound was purified by column chromatography

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Vangala, Madhuri; Shinde, Ganesh P.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2086 – 2092;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine

Under carbon dioxide atmosphere, 0.2 mmol of 1,3-butadiyne 1b, 0.2 mmol of cesium carbonate, 0.6 mmol of DBN, 20mul of water, and 2 mL of acetonitrile were successively added to a Schlenk reaction tube, and the mixture was heated at 70 C in IKA and stirred for 24 hours. After the reaction was completed, the reaction mixture was cooled to room temperature, and the reaction solution was transferred with 20 mL of ethyl acetate. The reaction mixture was evaporated under reduced pressure and subjected to column chromatography to give the desired product 3b (63%).

With the rapid development of chemical substances, we look forward to future research findings about 3001-72-7.

Reference:
Patent; Henan Normal University; Liu Jianming; Yue Yuanyuan; Yan Xuyang; Zhao Shufang; (11 pag.)CN107954979; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia