Category: 3001-72-7

Adding a certain compound to certain chemical reactions, such as: 3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3001-72-7, blongs to pyrimidines compound. Computed Properties of C7H12N2

General procedure: NaBPh4 (1 equiv) was added to a round-bottom flask and purged with nitrogen. Dry MeCN (to make a 0.2 M solution of NaBPh4) and the appropriate acyl chloride (1.04 equiv) were added and the resulting solution cooled to 0 C. DBN (1) (1 equiv) was added dropwise and a precipitate of NaCl began to form. The reaction was left to stir for 1 h before being warmed to room temperature and filtered through a pad of Celite, washing thoroughly with MeCN. The filtrate was then concentrated under reduced pressure and the resulting N-acyl DBN¡¤BPh4 salt purified by recrystallization from CH2Cl2 and hexane.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Taylor, James E.; Williams, Jonathan M.J.; Bull, Steven D.; Tetrahedron Letters; vol. 53; 32; (2012); p. 4074 – 4076;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3001-72-7, blongs to pyrimidines compound. category: pyrimidines

General procedure: The reaction mixture of azlactones 1a-p (0.2mmol) and DBN (2b, 0.03mL, 0.22mmol) was stirred at room temperature for the appropriate time according to Scheme 2. After completion of the reaction as monitored by TLC (eluent: petroleum ether/ethyl acetate, 4:1), the mixture was extracted with ethyl acetate (3¡Á5mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by silica gel column chromatography (10-35% ethyl acetate in petroleum ether) afforded the products 3ab-pb. 4.3.1 N-(1-(4-nitrophenyl)-3-oxo-decahydropyrrolo[1,2-a]pyrrolo[2,1-b]pyrimidin-2-yl)benzamide ( Scheme 2 , 3ab) 73.5 mg (0.18 mmol, 88%) as a light orange solid. m.p. 137-138 C (decomposed); IR (KBr): 3344, 2926, 2853, 1692, 1673, 1515, 1461, 1345 cm-1; 1H NMR (400 MHz, DMSO-d6): delta 9.82 (s, 1H), 8.27 (d, J = 8.8 Hz, 2H), 7.87 (d, J = 8.8 Hz, 2H), 7.82 (d, J = 7.2 Hz, 2H), 7.56 (t, J = 7.2 Hz, 1H), 7.46 (t, J = 7.4 Hz, 2H), 4.30 (td, J = 10.4, 2.2 Hz, 1H), 3.56 (dt, J = 12.0, 4.8 Hz, 1H), 3.46 (td, J = 10.2, 2.4 Hz, 1H), 3.24-3.13 (m, 1H), 2.96-2.83 (m, 1H), 2.68-2.57 (m, 1H), 2.45-2.31 (m, 1H), 2.08-1.96 (m, 1H), 1.81-1.77 (m, 2H), 1.73-1.60 (m, 1H), 1.35-1.24 (m, 1H); 13C NMR (100 MHz, CDCl3): delta 167.9, 164.5, 147.1, 142.4, 139.8, 133.2, 132.4, 129.6, 128.7, 127.5, 125.8, 122.8, 83.2, 51.9, 44.2, 38.6, 32.8, 21.2, 19.9; Anal. calcd for C23H22N4O4 (418.19): C 66.05, H 5.26, N 13.39; found C 65.98, H 5.29, N 13.43.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Rudbari, Hadi Amiri; Tetrahedron; vol. 73; 11; (2017); p. 1397 – 1406;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3001-72-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine. A new synthetic method of this compound is introduced below.

In a carbon dioxide atmosphere, 0.2 mmol of 1,3-butadiyne 1f, 0.2 mmol of cesium carbonate, 0.6 mmol of DBN, 20mul of water, and 2 mL of acetonitrile were successively added to a Schlenk reaction tube, and the mixture was heated at 80 C in IKA and stirred for 24 hours. After the reaction was completed, the reaction mixture was cooled to room temperature, and the reaction mixture was transferred with 20 mL of ethyl acetate. The reaction mixture was filtered under reduced pressure and purified by column chromatography to give the desired product 3f (46%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Patent; Henan Normal University; Liu Jianming; Yue Yuanyuan; Yan Xuyang; Zhao Shufang; (11 pag.)CN107954979; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3001-72-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of DBN (124 mg, 1 mmol) in MeCN (4 mL), a solution of methyl 4-hydroxy-4-methyl-2-pentynoate (1a; 142 mg, 1 mmol) in MeCN (3 mL) and H2O (1 mL) was added dropwise over 10 min. The reaction mixture was stirred at 20-25 C for 48 h. Solvent was evaporated in vacuo and the residue was washed with a mixture of hexane-acetone (1:1) to give the desired product 2a.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine.

Reference:
Article; Shemyakina, Olesya A.; Volostnykh, Olga G.; Stepanov, Anton V.; Mal’Kina, Anastasiya G.; Ushakov, Igor A.; Trofimov, Boris A.; Synthesis; vol. 50; 4; (2018); p. 853 – 858;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3001-72-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, molecular weight is 124.1836, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of DBN (124 mg, 1 mmol) in MeCN (4 mL), a solution of methyl 4-hydroxy-4-methyl-2-pentynoate (1a; 142 mg, 1 mmol) in MeCN (3 mL) and H2O (1 mL) was added dropwise over 10 min. The reaction mixture was stirred at 20-25 C for 48 h. Solvent was evaporated in vacuo and the residue was washed with a mixture of hexane-acetone (1:1) to give the desired product 2a.

Statistics shows that 3001-72-7 is playing an increasingly important role. we look forward to future research findings about 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine.

Reference:
Article; Shemyakina, Olesya A.; Volostnykh, Olga G.; Stepanov, Anton V.; Mal’Kina, Anastasiya G.; Ushakov, Igor A.; Trofimov, Boris A.; Synthesis; vol. 50; 4; (2018); p. 853 – 858;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia