Category: 30129-57-8

Synthetic Route of 30129-57-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30129-57-8, name is 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one, molecular formula is C6H6N4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-Methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (134 mg, 0.89 mmol.) was taken into thionyl chloride (3 mL) followed by addition of DMF (0.2 mL) and the mixture was brought to reflux over 30 minutes. The resulting solution was concentrated and the residue partitioned with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was washed with brine then dried over anhydrous sodium sulfate, filtered and concentrated to afford a yellow oil.

According to the analysis of related databases, 30129-57-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXELIXIS, INC.; WO2005/117909; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 30129-57-8, 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Example 63A 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine This compound was prepared according to a modified specification from: C. C. Cheng, R. K. Robins, J. Org. Chem. 1958, 23, 191. 4.878 g (33.2 mmol) of 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol (J. Org. Chem. 1958, 23, 191) was put in 50 ml toluene, 15.5 ml (165.8 mmol) of phosphoryl chloride and 12.7 ml (72.9 mmol) of diisopropyl ethylamine were added and it was stirred for 1 h at 80 C. It was concentrated by evaporation and distributed between ethyl acetate and 1 M hydrochloric acid. The organic phase was dried over sodium sulphate and concentrated by evaporation. The residue (4.464 g, 92% purity, 73% of theor.) was processed further without purification. LC-MS (method 1): Rt=0.53 min; MS (ESIpos): m/z=169 (M+H)+

The synthetic route of 30129-57-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; HUeBSCH, Walter; LINDNER, Niels; VAKALOPOULOS, Alexandros; TERSTEEGEN, Adrian; US2013/338137; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 30129-57-8, Adding some certain compound to certain chemical reactions, such as: 30129-57-8, name is 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one,molecular formula is C6H6N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30129-57-8.

6-Methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (134 mg, 0.89 mmol.) was taken into thionyl chloride (3 mL) followed by addition of DMF (0.2 mL) and the mixture was brought to reflux over 30 minutes. The resulting solution was concentrated and the residue partitioned with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was washed with brine then dried over anhydrous sodium sulfate, filtered and concentrated to afford a yellow oil.

According to the analysis of related databases, 30129-57-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXELIXIS, INC.; WO2005/117909; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 30129-57-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30129-57-8, name is 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one. This compound has unique chemical properties. The synthetic route is as follows.

3-Iodo-6-methyl-1 ,5-dihydro-4H-pyrazolo[3,4-dJpyrimidin-4-one. To a stirred20 suspension of 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (80.0 g, 533 mmol) in dimethylacetamide (800 mL) was added N-iodosuccinimide (180 g, 799 mmol) portion-wise over aperiod of 30 min. The reaction mixture vas heated to 130C for 3 hours. The reaction mixturewas cooled to 0C and poured into a saturated aqueous solution ofNa2S203 (1.8 L) with stining.The mixture was allowed to settle for 3 h and the precipitated brown solid was filtered. The25 isolated brown solid was suspended in THF:Cf:bCN:MeOH:FhO (3:3:2:3) and stirred for 16 h.The resulting solid was filtered and dried under vacuum to provide the title compound (60 g,41 ~o) as a brown solid. 1H NNIR (400 NIHz, DMSO-do) 8 13.02 (s, 1H), 12.04 (s, 1H), 2.32 (s,3H). [M+H] ‘” 276.9.

According to the analysis of related databases, 30129-57-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DART NEUROSCIENCE, LLC; GOMEZ, Laurent; VERNIER, William, Francois; (104 pag.)WO2018/125810; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia