Adding a certain compound to certain chemical reactions, such as: 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, blongs to pyrimidines compound. Quality Control of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Example 4.Preparation of the isoamyl alcohol solvate (SI) of dasatinib:The intermediate of formula II (0.42 g; 1.07 mmol), l-(2-hydroxyethyl)piperazine (0.8 g; 6.15mmol) and diisopropylethylamine (0.38 ml, 2.18 mmol) were suspended in isoamyl alcohol (7ml) under an inert atmosphere. The reaction mixture was stirred and heated up to 140C for 6hours. The reaction mixture was withdrawn from the heating bath and stirred intensively. Crystallization started at the inner temperature of 95C, the suspension was left to cool under continuous stirring. After achieving the laboratory temperature it was stirred for another 2 hours. The crystalline substance was aspirated on fit S3, washed with isoamyl alcohol (7 nil)and dried at the laboratory temperature in vacuo (2.5 kPa) for 5 hours. The yield was 0.5 g;81% of the theoretical yield. FIPLC purity 99.10%. The XRPD pattern corresponds to the isoamyl alcohol solvate (SI). The SI solvate is characterized by the reflections presented in Table 2:
At the same time, in my other blogs, there are other synthetic methods of this type of compound,302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; ZENTIVA, K.S.; ZELENKA, Karel; HAJICEK, Josef; DAMMER, Ondrej; WO2014/86326; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia