Reference of 304646-29-5 , The common heterocyclic compound, 304646-29-5, name is 2-Methoxy-5-nitropyrimidin-4-amine, molecular formula is C5H6N4O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of compound 6 (560 mg, 3.29 mmol) in MeOH (30 mL) was added 10% Pd on carbon (56.4 mg). After the mixture was stirred at 20 C under H2 (15 psi) for 1 h, it wasfiltered and the filtrate was concentrated to give compound 7 (310 mg, 2.21 mmol, 67.2% yield) as a brown solid.
The synthetic route of 304646-29-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; DRAGOVICH, Peter; PEI, Zhonghua; PILLOW, Thomas; SADOWSKY, Jack; CHEN, Jinhua; WAI, John; (237 pag.)WO2017/64675; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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