Category: 30561-07-0

Marcelis, A. T. M.’s team published research in Journal of Organic Chemistry in 1986 | CAS: 30561-07-0

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C6H7N3O4

Marcelis, A. T. M.; Van der Plas, H. C. published an article on January 10 ,1986. The article was titled 《Ring transformations of heterocycles with nucleophiles. 33. Cycloadditions of 5-nitropyrimidines with ynamines. Formation of 3-nitropyridines, N-5-pyrimidyl-α-carbamoylnitrones, and 2,2a-dihydroazeto[2,3-d]-3,5-diazocines》, and you may find the article in Journal of Organic Chemistry.Formula: C6H7N3O4 The information in the text is summarized as follows:

The reaction of pyrimidines containing an electron-withdrawing substituent at C-5 with ynamines RCCR1 (I; R,R1 = Me, Et2N; Ph, Me2N; Ph, pyrrolidino) was studied. 5-(Ethoxycarbonyl)- and 5-(methylsulfonyl)pyridine undergo [4 + 2] cycloaddition to yield the substituted pyridines II and III resp. 5-Nitropyrimidines containing 2- and/or 4(6)-alkoxy or Me groups give a variety of products upon reaction with I. 4,6-Dimethoxy-5-nitropyrimidine undergoes [4 + 2] cycloaddition to give pyridine derivative IV (R2 = MeO) upon reaction with I (R = Me, R1 = Et2N) (V). Nitrone VI (R2 = MeO) is formed as main product upon reaction of V with 2,4-dimethoxy-5-nitropyrimidine. 5-Nitropyrimidines unsubstituted at C-4 and C-6 give dihydroazeto[2,3-d]diazocines upon reaction with 2 equiv of V. 4-Methoxy-5-nitropyrimidine yields pyridine IV and nitrone VI (R3 = H, R4 = MeO) upon reaction with V, and from 4-methyl-5-nitropyriidine, the pyridines IV (R2 = H, Me) dihydroazetodiazocine VII, and a nitrone are formed. Ynamine I (R = Ph; R1 = Me2N) is less reactive than V and does not react to form dihydroazetodiazocines with the 5-nitropyrimidines. Instead, nitrone VIII (R5 = H) and pyridine IX are formed upon reaction of I (R = Ph, R1 = Me2N) with 5-nitropyrimidine, and nitrone VIII (R5 = Ph) is formed with 2-phenyl-5-nitropyrimidine. In the experiment, the researchers used 2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0Formula: C6H7N3O4)

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C6H7N3O4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brown, Desmond J.’s team published research in Journal of the Chemical Society [Section] C: Organic in 1970 | CAS: 30561-07-0

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 30561-07-0

In 1970,Journal of the Chemical Society [Section] C: Organic included an article by Brown, Desmond J.; Sugimoto, T.. Application of 30561-07-0. The article was titled 《Aza analogs of pteridine. II. Novel use of silver oxide in transetherification of alkoxy-1,2,4,6,8-pentaazanaphthalenes, alkoxynitropyrimidines, and related systems》. The information in the text is summarized as follows:

Alkoxy derivatives of 1,2,4,6,8-pentaazanaphthalene (pyrimido[5,4-e]-as-triazine) (I) undergo transetherification when treated with boiling alcs. in the presence of silver oxide. Appropriate methoxy compounds give 5-ethoxy-3-methyl-, 5-propoxy-3-methyl-, and (more slowly) 5-isopropoxy-3-methyl-pentaazanaphthalene; also 5,7-diethoxy-, 5,7-dipropoxy-, 5,7-diisopropoxy-, 5,7-diethoxy-3-methyl-, and 5-ethoxy-3,7-di-methylpentaazanaphthalene. Synthetic routes to the methoxy substrates and to one of the products are reported; other structures are confirmed by uv and 1H NMR spectra. 4-Methoxypteridine undergoes transetherification similarly but simple alkoxypyrimidines and alkoxypyridines are resistant. However, the more highly activated 2-methoxy-5-nitro-, 4-methoxy-5-nitro-, and 2,4-dimethoxy-5-nitropyrimidine easily give their resp. propoxy homologs, and so does 2-methoxy-3,5-dinitropyridine. In contrast, 2,4-dimethoxy-6-methyl-5-nitropyrimidine gives only its 4-methoxy-2-propoxy homolog, and both 4,6-dimethoxy-5-nitro- and 4-methoxy-2,6-dimethyl-5-nitropyrimidine remain unchanged. The classical transetherification agent, ethanolic EtONa, reacts with 5,7-dimethoxypentaazanaphthalene to give the 7-ethoxy-5-hydroxy analog. This was identified by spectral comparison with its 5-hydroxy-7-methoxy homolog, itself synthesized by 5,6-addition of methanethiol to 7-methoxy-pentaazanaphthalene followed by dehydrogenation and selective hydrolysis. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0Application of 30561-07-0)

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 30561-07-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 30561-07-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30561-07-0, 2,4-Dimethoxy-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 30561-07-0, Adding some certain compound to certain chemical reactions, such as: 30561-07-0, name is 2,4-Dimethoxy-5-nitropyrimidine,molecular formula is C6H7N3O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30561-07-0.

To a QianCap glass reactor (1850 mL) equipped with magnetic stirrer was added C-7A2 (100 g, 540 mmol) followed by THF (800 mL). Next, 10 % palladium on carbon (2 g) was added in one portion and the reactor was connected to the source of the hydrogen. Hydrogen pressure was set at 2 bar and reaction was well stirred for 16 h under continuous flow of hydrogen. After that time, UPLCMS analysis has shown complete conversion of starting material. The reaction mixture was filtered through the Cellite pad and the filtrate was concentrated in vacuo to around 150 – 200 mL. Then, n-hexane (500 mL) was added dropwise and the suspension was stirred for 2 h at room temperature. The precipitate was filtered, washed twice with n-hexane (2 x 50 mL) and vacuum dried. As a result, amine C-7A was obtained as a yellow/green solid (77.94 g, 93 % yeld, 99 % purity according to UPLCMS analysis).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30561-07-0, 2,4-Dimethoxy-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Adamed sp. z o.o.; FEDER, Marcin; MAZUR, Maria; KALINOWSKA, Iwona; JASZCZEWSKA, Joanna; LEWANDOWSKI, Wojciech; WITKOWSKI, Jakub; JELEN, Sabina; WOS-LATOSI, Katarzyna; (56 pag.)EP3511334; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia