Category: 3122-84-7

Lefranc, Julien published the artcileDiscovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor, SDS of cas: 3122-84-7, the main research area is BAY985 TBK1 IKK epsilon inhibitor antitumor activity antiproliferative melanoma.

The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homolog IKKε are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particular, in inflammation. Herein, we describe our investigations on a family of benzimidazoles and the identification of the potent and highly selective TBK1/IKKε inhibitor BAY-985. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3122-84-7 belongs to class pyrimidines, name is 4-Chloro-6-(methoxymethyl)pyrimidine, and the molecular formula is C6H7ClN2O, SDS of cas: 3122-84-7.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gadhachanda, Venkat R. published the artcile4-Aminopyrimidines as novel HIV-1 inhibitors, Application of 4-Chloro-6-(methoxymethyl)pyrimidine, the main research area is aminopyrimidine preparation HIV1 inhibitor SAR.

A series of 4-aminopyrimidines was identified as novel HIV inhibitors of unknown mol. target. Structural modifications were carried out to establish SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-HIV agents. 3122-84-7 belongs to class pyrimidines, name is 4-Chloro-6-(methoxymethyl)pyrimidine, and the molecular formula is C6H7ClN2O, Application of 4-Chloro-6-(methoxymethyl)pyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Homon, Anton A. published the artcileSynthesis of 3-Azabicyclo[3.2.0]heptane-Derived Building Blocks via [3+2] Cycloaddition, Recommanded Product: 4-Chloro-6-(methoxymethyl)pyrimidine, the main research area is azabicyclo heptane derivative; cyclobuteneraboxylic acid ester cycloaddition.

An efficient approach to synthesis of various substituted 3-azabicyclo[3.2.0]heptane-derived building blocks based on [3+2] cycloaddition of cyclobut-1-eneraboxylic acid ester and in situ generated azomethine ylide was developed and applied on multigram scale. The utility of 1,3-disubstituted 3-azabicyclo[3.2.0]heptane scaffold was demonstrated by addnl. structural anal. using exit vector plot (EVP) tool, and tested in parallel synthesis of compound library.

European Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction. 3122-84-7 belongs to class pyrimidines, name is 4-Chloro-6-(methoxymethyl)pyrimidine, and the molecular formula is C6H7ClN2O, Recommanded Product: 4-Chloro-6-(methoxymethyl)pyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia